Article
Endocrinology & Metabolism
Dandan Song, Huan He, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Indranil Sinha, Lars-Arne Haldosen, Chunyan Zhao, Cecilia Williams
Summary: This study investigates the differences between estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in regulating cell proliferation and migration. The results show that ERα and ERβ have opposite effects on cell proliferation and different impacts on migration. Furthermore, they regulate distinct sets of target genes, providing valuable insights into the mechanisms of these two different ER isoforms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Lian Ren, Fang Li, Ziyang Di, Yan Xiong, Shichen Zhang, Qing Ma, Xiaoen Bian, Zhiquan Lang, Qifa Ye, Yanfeng Wang
Summary: This study found that females have less extensive kidney damage in renal ischemia-reperfusion injury (IRI) compared to males. However, this protection diminishes after menopause, suggesting a role for estrogen in IRI. The study revealed that estradiol (E-2) supplementation ameliorates kidney injury and fibrosis in female rats, and the levels of TGF-beta RI are increased in ovariectomized rats. Further investigation showed that ER alpha could negatively regulate the expression of TGF-beta RI and that ER alpha knockdown blocked E-2-mediated protection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dina Hany, Vasiliki Vafeiadou, Didier Picard
Summary: High levels of PAICS enzyme activity in breast cancer can make ERα activation estrogen-independent and tamoxifen-resistant. Combined targeting of PAICS and ERα may serve as a new, effective, and potentially safe therapeutic regimen.
Article
Oncology
Jharna Datta, Natalie Willingham, Jasmine M. Manouchehri, Patrick Schnell, Mirisha Sheth, Joel J. David, Mahmoud Kassem, Tyler A. Wilson, Hanna S. Radomska, Christopher C. Coss, Chad E. Bennett, Ramesh K. Ganju, Sagar D. Sardesai, Maryam Lustberg, Bhuvaneswari Ramaswamy, Daniel G. Stover, Mathew A. Cherian
Summary: Highly selective ER beta agonists have been shown to effectively inhibit the viability of ER alpha+ breast cancer cell lines in vitro, suggesting a potential therapeutic strategy for ER alpha+ breast cancer. The combination of ER beta agonists with ER alpha antagonists shows strong synergy, maximizing the efficacy of ER beta agonists in blocking cell proliferation, migration, and inducing apoptosis. Negative correlation between ESR2 (ER beta gene) expression and ESR1 (ER alpha gene) and CCND1 RNA expression was observed in human metastatic ER alpha+/HER2- breast cancer samples.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Keita Furuminato, Saki Minatoya, Eriko Senoo, Tatsuki Goto, Sho Yamazaki, Moeka Sakaguchi, Kenji Toyota, Taisen Iguchi, Shinichi Miyagawa
Summary: Estrogens are crucial for uterine growth and homeostasis through interactions with estrogen receptors. This study showed that the knockout of Esr1 in mouse uterine stroma impaired estrogen responsiveness and subsequent growth, indicating the importance of mesenchymal ESR1 in both epithelial and mesenchymal cell proliferation. RNA-seq analysis revealed that the majority of estrogen-induced genes were regulated by stromal ESR1, including growth factors, cytokines, and genes involved in lipid homeostasis.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Basma Ghazi Eid
Summary: Chrysin has protective effects on estradiol-induced endometrial hyperplasia, exerting anti-proliferative, anti-oxidant, and anti-inflammatory effects partially through increasing PPAR alpha activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Arathi Rajan, Revathy Nadhan, Neetha Rajan Latha, Neethu Krishnan, Arathy Warrier, Priya Srinivas
Summary: Individuals with BRCA1 mutations are more prone to developing cancers in hormone-responsive tissues, which do not respond well to hormone therapy and exhibit increased DNA damages. There is a cross regulatory signaling network between ER-alpha and BRCA1, and understanding this interaction is crucial for drug development and therapy for breast/ovarian cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Toxicology
Aziza Hussein Bakheit Adam, Laura H. J. de Haan, Jochem Louisse, Ivonne M. C. M. Rietjens, Lenny Kamelia
Summary: The study found that the zebrafish embryotoxicity test (ZET) can better capture the developmental toxicity of diethylstilbestrol (DES) compared to the embryonic stem cells test (EST). Differences in developmental toxicity effects between DES and 17β-estradiol (E2) were identified in the ZET, confirming the role of ER alpha in mediating DES-induced developmental toxicity.
TOXICOLOGY IN VITRO
(2021)
Article
Oncology
Abigail Schoeller, Keshav Karki, Arul Jayaraman, Robert S. Chapkin, Stephen Safe
Summary: Early stage ER alpha-positive breast cancer patients with aggressive endocrine-resistant tumors expressing mutant forms of ER alpha can be treated with selective ER down regulators (SERDs). HDAC inhibitors and dietary short chain fatty acids (SCFAs) may have similar effects on downregulating ER alpha.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Reproductive Biology
Lei Sun, Wei-Xue Ji, Yan Li, Ze-Lian Li, Can-Can Duan, Bai-rong Xia, Lan Xiao
Summary: In epithelial ovarian cancer, increased expression of PAPSS1 is associated with tumor stage, histological subtype, metastasis, and recurrence. Down-regulation of PAPSS1 enhances sensitivity to cisplatin in both in vitro and in vivo experiments. Additionally, low nuclear PAPSS1 and high nuclear ERa expression are correlated with longer overall survival and progression-free survival in ovarian cancer patients.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Immunology
Gaelle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, Francois Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frederick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Summary: Cellular adaptation to low oxygen tension and metabolic stress in injured tissues is crucial for the proper functioning of inflammatory cells. In this study, we show that the inositol-requiring enzyme 1 alpha (IRE1 alpha/XBP1) axis is required for the initiation of HIF1 alpha-dependent cytokine production in innate immune cells. Knockout of either HIF1 alpha or IRE1 alpha improves vascular phenotypes in a model of retinal pathological angiogenesis driven by sterile inflammation. Thus, ER stress pathways, in partnership with HIF1 alpha, may co-regulate immune adaptation to low oxygen.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Cell Biology
Bahriye Karakas, Yeliz Aka, Asli Giray, Sehime Gulsun Temel, Ufuk Acikbas, Huveyda Basaga, Ozgur Gul, Ozgur Kutuk
Summary: Dynamic BH3 profiling technology can predict the response to endocrine therapy agents and the development of acquired resistance in breast cancer cells independently of estrogen receptor status. Mitochondrial ER-beta plays a crucial role in breast cancer cells, and selective ER-beta agonists may be a novel targeted therapy for breast cancer.
CELL DEATH DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
Mariam Rusidze, Marine Adlanmerini, Elodie Chantalat, I. Raymond-Letron, Surya Cayre, Jean-Francois Arnal, Marie-Ange Deugnier, Francoise Lenfant
Summary: This review discusses the role of ER alpha in mammary gland development and breast cancer progression, highlighting both the classical nuclear genomic and membrane non-genomic actions of ER alpha in regulating mammary development at different stages. It also provides an overview of the characteristics of luminal cell lineage expressing ER alpha and the impact of ER alpha signaling in transgenic mouse models, emphasizing its pivotal role in mammary gland morphogenesis and function as well as its implication in tumorigenesis. Additionally, the review covers the main features of ER alpha-positive luminal breast cancers and their modeling in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Physical
Tereza Bosakova, Antonin Tockstein, Zuzana Bosakova, Katerina Komrskova
Summary: The study aimed to investigate the interactions between 17 alpha-estradiol and sperm ER during sperm capacitation, developing a kinetic model. New autocatalytic formation of an unstable adduct between alpha E2 and ER was discovered, contributing to the understanding of tissue rejuvenation and cancer physiology related to alpha E2 signaling.
Article
Multidisciplinary Sciences
H. James McQuillan, Jenny Clarkson, Alexia Kauff, Su Young Han, Siew Hoong Yip, Isaiah Cheong, Robert Porteous, Alison K. Heather, Allan E. Herbison
Summary: This study reveals the mechanisms underlying the homeostatic estrogen negative feedback pathway and demonstrates the crucial role of estradiol-dependent plasticity in pulse generator synchronization events. The study also provides experimental evidence that estrogen receptor alpha in hypothalamic kisspeptin neurons is the principal pathway for estrogen negative feedback in mice.
NATURE COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Margaret S. Blattner, Megan M. Mahoney
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Endocrinology & Metabolism
S. E. Royston, D. Bunick, M. M. Mahoney
JOURNAL OF NEUROENDOCRINOLOGY
(2016)
Article
Reproductive Biology
Megan M. Mahoney, Brooke V. Rossi, Megan H. Hagenauer, Theresa M. Lee
BIOLOGY OF REPRODUCTION
(2011)
Article
Endocrinology & Metabolism
S. E. Royston, N. Yasui, A. G. Kondilis, S. V. Lord, J. A. Katzenellenbogen, M. M. Mahoney
Article
Behavioral Sciences
M. S. Blattner, M. M. Mahoney
GENES BRAIN AND BEHAVIOR
(2012)
Article
Behavioral Sciences
Rebecca Brockman, David Bunick, Megan M. Mahoney
HORMONES AND BEHAVIOR
(2011)
Article
Biology
Margaret S. Blattner, Megan M. Mahoney
JOURNAL OF BIOLOGICAL RHYTHMS
(2013)
Article
Neurosciences
Jessica A. Mong, Fiona C. Baker, Megan M. Mahoney, Ketema N. Paul, Michael D. Schwartz, Kazue Semba, Rae Silver
JOURNAL OF NEUROSCIENCE
(2011)
Article
Veterinary Sciences
Gary R. Steinberg, Julie K. Byron, Megan M. Mahoney
JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE
(2012)
Article
Clinical Neurology
Ayelet Ziv-Gal, Jodi A. Flaws, Megan M. Mahoney, Susan R. Miller, Howard A. Zacur, Lisa Gallicchio
Review
Endocrinology & Metabolism
Megan M. Mahoney
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2010)
Review
Neurosciences
Katherine M. Hatcher, Sara E. Royston, Megan M. Mahoney
EUROPEAN JOURNAL OF NEUROSCIENCE
(2020)
Article
Psychology, Biological
Katherine M. Hatcher, Jan Willing, Catheryne Chiang, Saniya Rattan, Jodi A. Flaws, Megan M. Mahoney
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Public, Environmental & Occupational Health
Katherine M. Hatcher, Rebecca L. Smith, Catheryne Chiang, Jodi A. Flaws, Megan M. Mahoney
Summary: Sleep disruptions during menopause can be influenced by factors such as depression, hot flashes, and hormone fluctuations. This study used a Bayesian network to examine the complex relationship between these factors and sleep in midlife women.
JOURNAL OF WOMENS HEALTH
(2023)