Article
Public, Environmental & Occupational Health
Heidi M. Lammers-van der Holst, James K. Wyatt, Todd S. Horowitz, John C. Wise, Wei Wang, Joseph M. Ronda, Jeanne F. Duffy, Charles A. Czeisler
Summary: The study found that using intermittent bright light during work hours can enhance adaptation to night shift work and reduce cognitive deficits on evening and day shifts. For workers who need to work night shifts and frequently rotate shifts, this light therapy may be an effective workplace intervention.
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
(2021)
Article
Biotechnology & Applied Microbiology
Qinglin Li, Shengkui Zhang, Han Wang, Zhende Wang, Xiaohong Zhang, Yongbin Wang, Juxiang Yuan
Summary: This study aimed to investigate the association between rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms, and type 2 diabetes among steelworkers. The results showed that rotating night shift work and Rs1387153 variants in MTNR1B were associated with an increased risk of type 2 diabetes. The complex interaction of MTNR1A-MTNR1B-CLOCK-rotating night shift work may further increase the risk of type 2 diabetes.
Article
Endocrinology & Metabolism
Jingyi Qian, Christopher J. Morris, Andrew J. K. Phillips, Peng Li, Shadab A. Rahman, Wei Wang, Kun Hu, Josephine Arendt, Charles A. Czeisler, Frank A. J. L. Scheer
Summary: In a controlled simulated night shift protocol, it was unexpectedly found that melatonin levels were significantly increased during daytime sleep, leading to a secondary melatonin peak during the circadian day. This challenges our current understanding of the regulation of melatonin secretion.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sorina Hohor, Cristina Mandanach, Andreea Maftei, Corina Aurelia Zugravu, Marina Ruxandra Otelea
Summary: Metabolic syndrome is associated with working in shifts, which causes sleep-wake rhythm misalignment, metabolic dysregulation, and oxidative stress. Melatonin, regulated by hypothalamic suprachiasmatic nuclei and light exposure, plays a role in promoting sleep, inhibiting wake-signals, acting as an antioxidant, and influencing cardiovascular functionality and metabolic processes. This review presents data on the influence of night shifts on melatonin secretion and oxidative stress, contributing to a better understanding of the pathological links between chronodisruption and metabolic syndrome related to shift work.
Article
Medicine, General & Internal
Zhihao Xiao, Cheng Xu, Qian Liu, Qing Yan, Jingjia Liang, Zhenkun Weng, Xin Zhang, Jin Xu, Dong Hang, Aihua Gu
Summary: This prospective cohort study suggests that night shift work is associated with incident hypertension, and this association is modified by genetic susceptibility to hypertension. The findings of this study indicate a joint effect of night shift work and genetic risk on hypertension.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Seungho Lee, Jae Bum Park, Kyung-Jong Lee, Seunghon Ham, Inchul Jeong
Summary: This study investigated the relationship between work organization and insomnia patterns among night shift workers in a hospital. Results showed that the lack of nap opportunities and work-time control were associated with the occurrence of insomnia, while over 5 years of shift work experience was linked to the resolution of insomnia. Work-related factors were significant in predicting insomnia risk, but not in the sustained insomnia group. Well-designed work schedules and better work organization could help reduce insomnia among night shift workers.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Shadab A. Rahman, George C. Brainard, Charles A. Czeisler, Steven W. Lockley
Summary: Intermittent light pulses are more efficient than continuous exposure in resetting the phase of the human circadian pacemaker, with melatonin suppression being significantly higher under continuous light exposure. The study also suggests a non-linear relationship between light exposure duration and phase resetting responses, highlighting the potential role of light wavelength in mediating these responses.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Immunology
Sarah Stenger, Hanna Grasshoff, Jennifer Elisabeth Hundt, Tanja Lange
Summary: Shift work is associated with an increased risk of systemic autoimmune diseases due to chronic inflammation, impaired immune responses, and circadian disruption. The effects of shift work on skin-specific autoimmune diseases are still not well understood. This review examines the impact of shift work, circadian misalignment, poor sleep, and potential hormonal mediators on skin barrier functions and immunity, using both human studies and animal models. The review also discusses confounders and possible countermeasures to reduce the risk of autoimmune diseases in shift workers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Marie -Anne Melone, Taylor C. Becker, Linder H. Wendt, Patrick Ten Eyck, Shruti B. Patel, Jason Poston, Anne S. Pohlman, Mark Pohlman, Annette Miller, Arlet Nedeltcheva, Jesse B. Hall, Eve Van Cauter, Joseph Zabner, Brian K. Gehlbach
Summary: Circadian dysrhythmias frequently occur in critically ill patients and are influenced by the underlying illness, ICU environment, and treatments. This study examined the relationship between clinical outcomes and 24-hour urinary 6-sulfatoxymelatonin (aMT6s) excretion profiles in 37 critically ill patients with shock and/or respiratory failure. The results showed that patients with rhythmic aMT6s excretion had higher chances of survival and being discharged home compared to patients with arrhythmic profiles, suggesting the potential of melatonin-based rhythm as a biomarker for critical illness severity.
Article
Biochemistry & Molecular Biology
Jennifer A. Ritonja, Kristan J. Aronson, Lisa Flaten, Danai G. Topouza, Qing Ling Duan, Francine Durocher, Joan E. Tranmer, Parveen Bhatti
Summary: Night shift work is associated with differential methylation in core circadian genes, including CSNK1E, NR1D1, and ARNTL. Night shift workers may exhibit different methylation levels in specific gene regions.
Review
Biology
Madeline Gibson
Summary: Night shift workers may experience increased oxidative stress due to circadian rhythm disruption, potentially impacting their health. Further research is needed to understand causality and promote the long-term health of night shift workers.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Katarzyna Burek, Sylvia Rabstein, Thomas Kantermann, Celine Vetter, Markus Rotter, Rui Wang-Sattler, Martin Lehnert, Dirk Pallapies, Karl-Heinz Joeckel, Thomas Bruening, Thomas Behrens
Summary: This study examined the impact of night shift on salivary cortisol levels at awakening and the cortisol awakening response (CAR). The results showed that shift workers had lower cortisol levels at awakening before day shifts and lower CARs after night shifts compared to non-shift workers. This effect was most pronounced in early chronotypes.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Mengying Yang, Jiaxing Huang, Shuhui Zhang, Xin Zhao, Daofu Feng, Xizeng Feng
Summary: The study revealed the adverse effects of 6-BA on zebrafish larvae's circadian rhythm and cardiovascular system, while melatonin exhibited a protective role in alleviating the toxicity induced by 6-BA and regulating the thyroid system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Materials Science, Biomaterials
Amey Joshi, Isaac Kirubakaran Sundar
Summary: Globalization and the need for round-the-clock essential services have led to shift-based schedules for workers. Night shift work (NSW) disrupts the internal circadian rhythm and can have an impact on inflammatory and metabolic pathways. This review discusses the effects of NSW on lung inflammation and associated pathophysiology in chronic lung diseases, including asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and COVID-19. It also explores the limitations of our current understanding and potential future advancements in chronotherapy.
Article
Oncology
Nhung Thi Hong Van, Tung Hoang, Seung-Kwon Myung
Summary: A meta-analysis of 32 observational studies found that night shift work significantly increased the risk of breast cancer, especially in case-control studies. No significant association was found in nested case-control studies and cohort studies, indicating that cohort studies provide higher evidence of no association between night shift work and the risk of breast cancer.