Review
Clinical Neurology
Emily J. Ricketts, Daniel S. Joyce, Ariel J. Rissman, Helen J. Burgess, Christopher S. Colwell, Leon C. Lack, Michael Gradisar
Summary: Light exposure plays a significant role in regulating circadian rhythms, and disruptions to this regulation can lead to various impairments. This is particularly relevant for adolescents, whose sleep-wake patterns are affected by reduced daytime light exposure and prolonged use of electronic devices in the evening. Implementing measures to adjust light intensity, spectra, duration, and delivery modality can support the sleep-wake health of adolescents in different contexts.
SLEEP MEDICINE REVIEWS
(2022)
Article
Public, Environmental & Occupational Health
Xiao-Qian Chen, Xiu-Min Jiang, Qing-Xiang Zheng, Hai-Wei Wang, Heng Xue, Yu-Qing Pan, Yan-Ping Liao, Xiao-Xia Gao
Summary: This study aimed to explore the factors influencing sub-health and circadian rhythm disorder among midwives and examine the relationship between circadian rhythm disorder and sub-health. A cross-sectional study was conducted among 91 Chinese midwives from six hospitals using cluster sampling. The results showed that sub-health and circadian rhythm disorder were common among midwives and were significantly related to age, exercise duration, working hours, job satisfaction, cortisol rhythm, and melatonin rhythm. Nurse administrators should take measures to prevent sub-health and circadian rhythm disorder among midwives.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Nutrition & Dietetics
Asuka Ishihara, Amber B. Courville, Kong Y. Chen
Summary: Light is crucial for many life forms and the natural light-dark cycle has been a dominant factor for circadian rhythms throughout human evolution. Artificial light has altered human activity patterns and allowed for extended periods of wakefulness outside of natural day-night cycles. However, increased exposure to light at inappropriate times or a reduced range of light between day and night can have negative effects on human health.
Article
Chemistry, Analytical
Meenakshi Pundir, Liubov Lobanova, Silvana Papagerakis, Xiongbiao Chen, Petros Papagerakis
Summary: This study presents the development of a novel colorimetric assay for the rapid and sensitive detection of salivary melatonin. The assay showed high sensitivity and selectivity, and could be used in a point-of-care system to accurately diagnose and monitor circadian rhythm sleep disorders.
ANALYTICA CHIMICA ACTA
(2023)
Article
Anesthesiology
Jingjing Li, Shining Cai, Xiao Liu, Jinghua Mei, Wenyan Pan, Ming Zhong, Yuxia Zhang
Summary: This study investigated the relationship between delirium and the circadian rhythms of melatonin, cortisol, and sleep in ICU patients. The results showed that the disturbance of melatonin and cortisol secretion rhythms was associated with the development of delirium. Therefore, it is important for clinical staff to pay attention to maintaining normal circadian rhythms in ICU patients.
BMC ANESTHESIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Priyanka Sarena, Ashish Sharma, Maiko T. Urmera, Murtaza M. Tambuwala, Alaa A. A. Aljabali, Dinesh Kumar Chellappan, Kamal Dua, Rajeev Taliyan, Rohit Goyal
Summary: This study investigated the effects of chronic exposure to light-light conditions on circadian rhythm dysfunction and dementia in Wistar rats. The results showed that the LL period significantly increased brain glutamate and cortisol levels, and impaired spatial memory, working memory, decision making, and exploration of novel objects. Histological study revealed neuropathological changes in the hippocampus, cortex, and cerebellum regions. Furthermore, oxidative stress in brain tissue was observed. However, treatment with dextromethorphan, mifepristone, and melatonin reversed the pathological states caused by LL.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Roberto Zefferino, Sante Di Gioia, Massimo Conese
Summary: The article reviews the complex relations among important molecules in the CNS, IS, and ES during chronic stress. A speculative hypothesis is proposed regarding the interplay of signaling molecules, with IL-1beta highlighted as a main biomarker of these effects.
BRAIN AND BEHAVIOR
(2021)
Article
Biology
Michal Mateusz Dermanowski, Arkadiusz Hejduk, Julita Kuczynska, Adam Wichniak, Agnieszka Urbanska, Pawel Mierzejewski
Summary: The study established a method for determining the concentration of melatonin (MELA) in plasma and saliva using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The correlation between plasma and salivary MELA concentration was analyzed, and the dim light melatonin onset (DLMO) was evaluated using both matrices. The results showed a strong correlation between plasma and salivary MELA concentration, and the DLMO calculated based on both plasma and saliva profiles were also correlated.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
David A. Areshidze, Maria A. Kozlova, Maxim V. Mnikhovich, Tatyana V. Bezuglova, Valery P. Chernikov, Zarina V. Gioeva, Aleksey V. Borisov
Summary: A study was conducted on mice with transplantable melanoma B16 to examine their morphofunctional condition under normal daylight regime, constant lighting, and constant darkness. The results showed that constant lighting intensified the proliferation of melanoma cells, resulting in greater tumor growth and spread, more pronounced secondary changes, and increased perivascular growth and perineural invasion. Conversely, keeping the animals in constant darkness significantly reduced the intensity of tumor cell proliferation and led to tumor regression without signs of lympho-, intravascular, and intraneural invasion. Micromorphometric studies confirmed intergroup differences in tumor cell status. Additionally, the study revealed that constant light suppressed the expression of clock genes, while constant darkness led to its intensification.
Article
Biology
Daniel S. S. Joyce, Manuel Spitschan, Jamie M. M. Zeitzer
Summary: In this study, the impact of different durations of light flash sequences on the human circadian pacemaker was examined. It was found that 15 minutes of light flashes can have a similar effect on circadian timing as 3.5 hours of light flashes. The retinohypothalamic circuit responsible for shifting the timing of the circadian pacemaker becomes refractory to further stimulation after the first 15 minutes of exposure.
Article
Endocrinology & Metabolism
Giulia Zerbini, Eva C. Winnebeck, Martha Merrow
Summary: The study reveals that both season and weekly schedule impact the phase of entrainment and sleep in humans. In summer, the phase of entrainment is about 1 hour earlier compared to winter, with shorter sleep duration, particularly affecting individuals with later chronotypes. These findings suggest that the phase of entrainment is linked to midday or midnight rather than sunrise or sunset.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Andrew W. McHill, Akane Sano, Cassie J. Hilditch, Laura K. Barger, Charles A. Czeisler, Rosalind Picard, Elizabeth B. Klerman
Summary: This study found that melatonin timing and sleep behaviors were stable in 15 university students, with minimal changes over a period of 100 days, which holds promise for understanding the reliability of previous reports on circadian rhythms and for developing personalized strategies to address circadian-associated diseases and impaired safety.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Haimei Xie, Xiaomei Zheng, Ye Huang, Weihao Li, Wenkai Wang, Qiao Li, Jiangtao Hou, Lulu Luo, Xiuying Kuang, Chuan-Quan Lin
Summary: Saliva composition has diurnal variations, which are not affected by citric acid stimulation. The variation characteristics of male and female under resting state and acid stimulation are basically the same, with the trend of salivary alpha-amylase activity being opposite to that of cortisol.
Article
Endocrinology & Metabolism
Lauren E. Hartstein, Cecilia Diniz Behn, Lameese D. Akacem, Nora Stack, Kenneth P. Wright, Monique K. LeBourgeois
Summary: The intensity of evening light is related to melatonin suppression in young children, with low-intensity light having a more pronounced effect. Additionally, melatonin levels remain below baseline for at least 50 minutes after light exposure.
JOURNAL OF PINEAL RESEARCH
(2022)
