Article
Endocrinology & Metabolism
Mathilde Reyt, Michele Deantoni, Marion Baillet, Alexia Lesoinne, Sophie Laloux, Eric Lambot, Justine Demeuse, Chiara Calaprice, Caroline LeGoff, Fabienne Collette, Gilles Vandewalle, Pierre Maquet, Vincenzo Muto, Gregory Hammad, Christina Schmidt
Summary: This study found an association between daytime rest and 24-hour rest probability profiles, circadian timing, and neurobehavioral outcomes in healthy older adults. The results suggest that increasing daytime rest frequency is related to more fragmented nighttime rest and lower episodic memory performance.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen
Summary: Blood pressure follows a circadian rhythm, with disruptions potentially leading to worsened cardiovascular and renal outcomes. This review summarizes current understanding of the circadian blood pressure regulation and provides a therapeutic overview of its relationship to cardiovascular and renal health and disease.
Article
Clinical Neurology
Chris Ho Ching Yeung, Cici Bauer, Qian Xiao
Summary: People with disrupted circadian rhythms, such as shift workers, have a higher risk of hypertension. This study found an association between weakened rest-activity rhythms and higher odds of hypertension, providing insight into preventing hypertension and cardiovascular diseases.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Rosa Sommer, Lei Yu, Julie A. Schneider, David A. Bennett, Aron S. Buchman, Andrew S. P. Lim
Summary: The disrupted circadian rest-activity rhythms in older adults are associated with a higher burden of cerebral small vessel disease, influencing the severity of arteriolosclerosis, atherosclerosis, and infarcts.
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Chen Lin, Wei-Chih Chin, Yu-Shu Huang, Kuo-Chung Chu, Teresa Paiva, Chia-Chi Chen, Christian Guilleminault
Summary: The study revealed that circadian rest-active rhythms in asymptomatic periods for KLS patients showed no significant difference compared to controls, but during hypersomnia attacks, the amplitude of the circadian rhythms drastically decreased. Further analysis identified several parameters including M10, IS, and alpha 1, which may serve as physiological markers of KLS and help predict the end of hypersomnia episodes.
Article
Materials Science, Biomaterials
Inga M. M. Antonsdottir, Dominique V. V. Low, Diefei Chen, Jill A. A. Rabinowitz, Yiwei Yue, Jacek Urbanek, Mark N. N. Wu, Jamie M. M. Zeitzer, Paul B. B. Rosenberg, Leah F. F. Friedman, Javaid I. I. Sheikh, Jerome A. A. Yesavage, Vadim Zipunnikov, Adam P. P. Spira
Summary: Little is known about the relationship between circadian rhythm alterations, neuropsychiatric symptoms, and cognition in memory impaired older adults. This study examined the associations of actigraphic rest/activity rhythms with depressive symptoms and cognition in this population. The findings suggest that depressive symptoms are associated with increased activity in the afternoon, evening, and overnight into midday, while better cognitive performance is associated with increased activity in the morning and afternoon.
Article
Physiology
Antonino Mule, Eleonora Bruno, Patrizia Pasanisi, Letizia Galasso, Lucia Castelli, Andrea Caumo, Fabio Esposito, Eliana Roveda, Angela Montaruli
Summary: This study compares the circadian rhythm characteristics of males and females with Metabolic Syndrome, showing that females exhibit higher daily activity levels in certain parameters of circadian rhythm.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Domenico Di Raimondo, Gaia Musiari, Alessandra Casuccio, Daniela Colomba, Giuliana Rizzo, Edoardo Pirera, Antonio Pinto, Antonino Tuttolomondo
Summary: Several studies indicate that the degree of nocturnal blood pressure reduction is related to organ damage and prognosis in hypertensive patients, with extreme dippers potentially having the lowest 24-hour pressure load and less cardiac remodeling.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Jan Scott, Bruno Etain, Ashlee Grierson, Sharon Naismith, Elizabeth Scott, Ian Hickie
Summary: This study is the first to use network modelling to explore the statistical associations between clinical phenotypes of bipolar disorders and different subsets of 24-hour rest-activity rhythms markers. The results show that certain rhythms are associated with the stage of bipolar disorder and a family history of the disorder. Additionally, markers of circadian rhythmicity suggest that regulation of this system is weaker in later stages of the disorder compared to earlier stages.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Peripheral Vascular Disease
Natasha Morales-Ghinaglia, Michael Larsen, Fan He, Susan L. Calhoun, Alexandros N. Vgontzas, Jason Liao, Duanping Liao, Edward O. Bixler, Julio Fernandez-Mendoza
Summary: The circadian timing of sleep, specifically sleep midpoint and regularity, can modify the association between visceral adiposity and elevated blood pressure in adolescents. Deviations in sleep irregularity during school days and sleep midpoint during break days can increase the impact of visceral adipose tissue on elevated blood pressure. These findings suggest the importance of considering the circadian timing of sleep in relation to cardiovascular health in adolescents.
Article
Endocrinology & Metabolism
Jingen Li, Soumya Vungarala, Virend K. Somers, Junrui Di, Francisco Lopez-Jimenez, Naima Covassin
Summary: This study found an association between rest-activity rhythm and obesity. Low amplitude, low mesor, low stability, and high fragmentation of the rhythm were associated with general and abdominal obesity. These results highlight the importance of regulating circadian rhythm in obesity management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lulu Yang, Hongliang Feng, Jie Chen, Yun Kwok Wing, Christian Benedict, Xiao Tan, Jihui Zhang
Summary: This study found that disrupted circadian rest-activity rhythm (CRAR) is associated with cardiovascular diseases and mortality among people with type 2 diabetes. Specifically, individuals with low interdaily stability (IS) and relative amplitude (RA) had the highest risk of developing cardiovascular disease. Delayed L5 onset did not have a significant association with cardiovascular disease risk. Moreover, high intradaily variability (IV) and low RA were associated with all-cause and cardiovascular mortality.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Peripheral Vascular Disease
Tammy M. Brady, Jeanne Charleston, Junichi Ishigami, Edgar R. Miller, Kunihiro Matsushita, Lawrence J. Appel
Summary: The study suggests that resting for less than 5 minutes may be a reasonable alternative and improve the efficiency of hypertension screening programs for most individuals. Shorter rest periods did not result in significant differences in blood pressure measurement accuracy compared to the standard 5-minute rest period.
Article
Clinical Neurology
Kenji Obayashi, Keigo Saeki, Yuki Yamagami, Norio Kurumatani, Kazuma Sugie, Hiroshi Kataoka
Summary: The study found that Parkinson's disease (PD) patients exhibit a phase advance and amplitude reduction in their circadian activity rhythm (CAR), and as the PD stage progresses, these effects become more pronounced.
Article
Ethics
Timo Minssen, Sara Gerke, Mateo Aboy, Nicholson Price, Glenn Cohen
Summary: Medical machine learning presents challenges and questions in terms of regulatory evaluation and international considerations. Current regulatory approaches in the USA and Europe, as well as issues such as data privacy, exportation, bias, are being analyzed.
JOURNAL OF LAW AND THE BIOSCIENCES
(2021)
Article
Ethics
Laura Bradford, Mateo Aboy, Kathleen Liddell
Summary: The tightening of data protection rules under the EU's General Data Protection Regulation may affect cooperation in health research between the EU and the USA. The US-EU Privacy Shield may not be suitable for supporting complex health studies, and it is suggested that a sector-based adequacy determination based on US health privacy law be sought instead.
JOURNAL OF LAW AND THE BIOSCIENCES
(2021)
Article
Biology
Ramon C. Hermida, Michael H. Smolensky, Horia Balan, Richard J. Castriotta, Juan J. Crespo, Yaron Dagan, Sherine El-Toukhy, Jose R. Fernandez, Garret A. FitzGerald, Akio Fujimura, Yong-Jian Geng, Ramon G. Hermida-Ayala, Antonio P. Machado, Luiz Menna-Barreto, Artemio Mojon, Alfonso Otero, R. Daniel Rudic, Eva Schernhammer, Carsten Skarke, Tomoko Y. Steen, Martin E. Young, Xiaoyun Zhao
Summary: Current hypertension guidelines lack recommendations on treatment timing, overlooking the impact of circadian rhythms on medication effects. Studies on ingestion-time trials for hypertension should adhere to strict guidelines including recruitment of participants based on ABPM diagnosis, selecting treatment times based on internal biological time, and using ABPM as the primary method for blood pressure assessment.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Review
Biology
Ramon C. Hermida, Artemio Mojon, Jose R. Fernandez, Ramon G. Hermida-Ayala, Juan J. Crespo, Maria T. Rios, Manuel Dominguez-Sardina, Alfonso Otero, Michael H. Smolensky
Summary: Elevated asleep blood pressure and blunted sleep-time relative systolic blood pressure decline are significant prognostic markers of cardiovascular disease risk. Current hypertension guidelines overlook the importance of asleep blood pressure and recommend diagnosis based on office blood pressure measurements. Studies have shown that taking blood pressure-lowering medications at bedtime results in greater reduction of blood pressure and improved cardiovascular outcomes compared to morning intake.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Editorial Material
Law
Timo Minssen, Mateo Aboy
Summary: The Enlarged Board of Appeal of the European Patent Office ruled that computer-implemented simulations of technical systems or processes can be considered to solve technical problems and produce technical effects beyond computer implementation. This means that the established case law on computer-implemented inventions applies to simulations even if they do not have a direct linkage to physical reality.
JOURNAL OF INTELLECTUAL PROPERTY LAW & PRACTICE
(2021)
Review
Biology
Ramon G. Hermida-Ayala, Artemio Mojon, Jose R. Fernandez, Michael H. Smolensky, Ramon C. Hermida
Summary: Research shows that taking dual-combination hypertension medications at bedtime/evening can lead to more significant benefits, including reduced asleep blood pressure, decreased prevalence of non-dipping blood pressure, fewer adverse effects, improved kidney function, and reduced cardiac pathology, compared to taking them upon waking/morning.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ramon C. Hermida, Diana E. Ayala, Artemio Mojon, Michael H. Smolensky, Juan J. Crespo, Alfonso Otero, Manuel Dominguez-Sardina, Ana Moya, Maria T. Rios, Maria C. Castineira, Pedro A. Callejas, Lorenzo Pousa, Elvira Sineiro, Jose L. Salgado, Carmen Duran, Juan J. Sanchez, Jose R. Fernandez
Summary: The study found that ABPM outperforms traditional OBPM in predicting cardiovascular disease outcomes, and can be used to replace in-clinic SBP measurements for improved accuracy. Using asleep systolic BP mean and sleep-time relative SBP decline as ABPM-derived predictive factors significantly enhanced the calibration, diagnostic accuracy, discrimination, and performance of the CVD risk stratification model.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Letter
Cardiac & Cardiovascular Systems
Ramon C. Hermida, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Article
Biotechnology & Applied Microbiology
Mateo Aboy, Kathleen Liddell, Matthew Jordan, Cristina Crespo, Johnathon Liddicoat
Summary: Obtaining European patent protection for medical uses of known products is not a key factor limiting repurposing activity.
NATURE BIOTECHNOLOGY
(2022)
Article
Law
Mauritz Kop, Mateo Aboy, Timo Minssen
JOURNAL OF INTELLECTUAL PROPERTY LAW & PRACTICE
(2022)
Article
Chemistry, Analytical
Sepehr Laal, Paul Vasilyev, Sean Pearson, Mateo Aboy, James McNames
Summary: An evaluation of a new wearable technology that combines inertial sensors and cameras for tracking human kinematics. This technology has the potential to overcome limitations of other dominant technologies, achieving accurate localization and mapping through SLAM algorithms.
Review
Clinical Neurology
Michael H. Smolensky, Ami P. Shah, Jose R. Fernandez, Linda Sackett-Lundeen, Ramon C. Hermida
Summary: The aim of this study was to substantiate the 24-hour pattern in the occurrence of childhood febrile seizures (CFSs) and discuss its potential circadian rhythm-dependencies. Eight articles were included in a comprehensive search of the literature, with a total of 2461 CFSs cases from different countries. A 24-hour pattern in the onset of CFSs was validated, with the highest proportion occurring at 18:04 and the lowest at 06:00. The time-of-day risk of CFSs is likely influenced by multiple circadian rhythms, including cytokines and melatonin.
Editorial Material
Biotechnology & Applied Microbiology
Mateo Aboy, W. Nicholson Price II, Seth Raker
Summary: According to patent office data, there is a significant and increasing number of patent applications for AI inventions in the medical field, which contradicts concerns that medical machine learning patents might face difficulties in meeting subject-matter eligibility requirements.
NATURE BIOTECHNOLOGY
(2023)
Review
Biology
Ramon C. Hermida, Michael H. Smolensky, Artemio Mojon, Jose R. Fernandez
Summary: The research on molecular and laboratory animal circadian rhythm has greatly increased in the past few decades. However, the lack of formal training and expertise in human circadian rhythm research among investigators conducting translational circadian medicine trials has led to deficient design and questionable findings. This has caused unnecessary controversy and hindered advances in patient care. Overall rating: 7/10
CHRONOBIOLOGY INTERNATIONAL
(2023)