Review
Pharmacology & Pharmacy
Ramon C. Hermida, Ramon G. Hermida-Ayala, Michael H. Smolensky, Artemio Mojon, Jose R. Fernandez
Summary: Current research suggests that taking hypertension medications at bedtime is more beneficial than taking them in the morning, leading to better reduction of asleep blood pressure, decreased cardiovascular disease risk, and improved organ function.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Medicine, General & Internal
Fabio Angeli, Gianpaolo Reboldi, Francesco Giuseppe Solano, Antonietta Prosciutto, Antonella Paolini, Martina Zappa, Claudia Bartolini, Andrea Santucci, Stefano Coiro, Paolo Verdecchia
Summary: Several outcome-based prospective investigations have shown the prognostic value of 24-hour ambulatory blood pressure monitoring in cardiovascular risk stratification. Average 24-hour, daytime, and nighttime blood pressures are essential components that improve risk assessment beyond traditional factors. However, the interpretation and clinical use of ambulatory blood pressure monitoring need standardization, and implementing its results in individual patient management remains challenging.
Review
Clinical Neurology
Ramon C. Hermida, Artemio Mojon, Ramon G. Hermida-Ayala, Michael H. Smolensky, Jose R. Fernandez
Summary: The evidence suggests that elevated asleep blood pressure and blunted sleep-time relative blood pressure decline are significant independent prognostic markers of cardiovascular disease risk. Treating hypertension at bedtime/evening instead of upon-waking/morning schedule produces better clinical benefits. Current guidelines do not adequately address this issue.
SLEEP MEDICINE REVIEWS
(2021)
Article
Peripheral Vascular Disease
Kazuomi Kario, Naoko Tomitani, Satoshi Hoshide, Masafumi Nishizawa, Tetsuro Yoshida, Tomoyuki Kabutoya, Takeshi Fujiwara, Hiroyuki Mizuno, Yukie Okawara, Hiroshi Kanegae, HI JAMP Study Grp
Summary: Home blood pressure control status defined using different thresholds can predict the control status of 24-hour ambulatory blood pressure in treated hypertension. When home blood pressure is controlled to less than 125/75 mm Hg, ambulatory blood pressure is well controlled.
Article
Peripheral Vascular Disease
Yiyi Zhang, Joseph E. Schwartz, Byron C. Jaeger, Jaejin An, Brandon K. Bellows, Donald Clark, Aisha T. Langford, Jolaade Kalinowski, Olugbenga Ogedegbe, John Jeffrey Carr, James G. Terry, Yuan-I. Min, Kristi Reynolds, Daichi Shimbo, Andrew E. Moran, Paul Muntner
Summary: The study suggests that higher diastolic BP and asleep SBP may be risk factors for subclinical atherosclerosis, highlighting the potential role of ambulatory BP monitoring in identifying individuals at high risk for coronary artery disease.
Article
Peripheral Vascular Disease
Eline H. Groenland, Jean-Paul A. C. Vendeville, Remy H. H. Bemelmans, Houshang Monajemi, Michiel L. Bots, Frank L. J. Visseren, Wilko Spiering
Summary: This study evaluated the agreement between app-assisted home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring, and found significant disagreement between the two methods. App-assisted home blood pressure monitoring had high sensitivity in diagnosing sustained and masked hypertension, and can be used as a complement to 24-hour ambulatory blood pressure monitoring.
Article
Medicine, General & Internal
Francesca Coccina, Anna M. Pierdomenico, Chiara Cuccurullo, Jacopo Pizzicannella, Oriana Trubiani, Sante D. Pierdomenico
Summary: The study aimed to assess the risk of heart failure in elderly treated hypertensive patients with different types of hypertension. The results showed that patients with uncontrolled hypertension, nonresistant hypertension, and resistant hypertension had a significantly higher risk of developing heart failure compared to those with controlled hypertension.
Article
Multidisciplinary Sciences
Jihei Sara Lee, Hye Ryeong Cha, Hyoung Won Bae, Sang Yeop Lee, Wungrak Choi, Seung Won Lee, Chan Yun Kim
Summary: The purpose of this study was to investigate the effect of antihypertensive medication on the risk of open-angle glaucoma (OAG) in patients diagnosed with hypertension. The study found that certain antihypertensive medications slightly increased the risk of OAG, but the effects were small. Further research is needed to understand the associations between hypertension, medication, therapeutic effect, and OAG.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Yibang Cheng, Yan Li, Jiguang Wang
Summary: Ambulatory blood pressure monitoring is crucial in the management of hypertension, as it aids in accurate diagnosis and cardiovascular risk assessment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Peripheral Vascular Disease
Emelina Stambolliu, Anastasios Kollias, Ioanna Bountzona, Angeliki Ntineri, George Servos, Andriani Vazeou, George S. Stergiou
Summary: This study shows that nighttime home blood pressure monitoring is feasible and closely associated with nighttime ambulatory blood pressure in children and adolescents, and similarly associated with preclinical organ damage.
Review
Peripheral Vascular Disease
Mark Mitsnefes, Joseph T. Flynn, Tammy Brady, Carissa Baker-Smith, Stephen R. Daniels, Laura L. Hayman, Andrew Tran, Justin P. Zachariah, Elaine M. Urbina
Summary: In 1997, Soergel et al published the first set of normative values for ambulatory blood pressure monitoring (ABPM) in children, which is now accepted as the standard method to confirm the diagnosis of hypertension in children. Despite significant progress in the field of pediatric ABPM, many important questions remain unanswered, such as how to define ambulatory hypertension in children.
Article
Public, Environmental & Occupational Health
Wei Gao, Yanwen Jin, Ting Bao, Yan Huang
Summary: Current studies have shown a high incidence of masked hypertension in Asian countries, but the use of ambulatory blood pressure monitoring (ABPM) is limited. This study compared ABPM and office blood pressure (OBP) in primary care for a high-risk population of hypertension. The results showed that ABPM had a significantly higher positive rate in diagnosing hypertension compared to OBP. ABPM can effectively screen for masked hypertension and nocturnal hypertension in primary care, making it necessary for high-risk populations.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Peripheral Vascular Disease
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
Summary: This study analyzed the association between home and ambulatory blood pressure monitoring and cardiovascular risk in hypertensive outpatients, and found that both home blood pressure and ambulatory blood pressure were independently associated with cardiovascular risk. Home blood pressure had a modest superiority to predict cardiovascular prognosis compared to ambulatory blood pressure.
Article
Endocrinology & Metabolism
Leif Karlsson, Lena Wallensteen, Anna Nordenstrom, Rafael T. Krmar, Svetlana Lajic
Summary: This study analyzed ambulatory blood pressure measurements in children and adults who were treated with dexamethasone (DEX) prenatally. The results suggest that DEX treatment does not adversely affect blood pressure in individuals unaffected by congenital adrenal hyperplasia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Jason Chung, Cal H. Robinson, Andrew Yu, Abdulaziz A. Bamhraz, Joycelyne E. Ewusie, Stephanie Sanger, Mark Mitsnefes, Rulan S. Parekh, Rupesh Raina, Lehana Thabane, Janis M. Dionne, Rahul Chanchlani
Summary: This systematic review found that children and adolescents with ambulatory hypertension have a higher risk of target organ damage, such as left ventricular hypertrophy, elevated left ventricular mass index, increased pulse wave velocity, and elevated carotid intima-media thickness. The findings highlight the importance of optimizing blood pressure control and screening for target organ damage in children with ambulatory hypertension.
Article
Biology
Ramon C. Hermida, Michael H. Smolensky, Horia Balan, Richard J. Castriotta, Juan J. Crespo, Yaron Dagan, Sherine El-Toukhy, Jose R. Fernandez, Garret A. FitzGerald, Akio Fujimura, Yong-Jian Geng, Ramon G. Hermida-Ayala, Antonio P. Machado, Luiz Menna-Barreto, Artemio Mojon, Alfonso Otero, R. Daniel Rudic, Eva Schernhammer, Carsten Skarke, Tomoko Y. Steen, Martin E. Young, Xiaoyun Zhao
Summary: Current hypertension guidelines lack recommendations on treatment timing, overlooking the impact of circadian rhythms on medication effects. Studies on ingestion-time trials for hypertension should adhere to strict guidelines including recruitment of participants based on ABPM diagnosis, selecting treatment times based on internal biological time, and using ABPM as the primary method for blood pressure assessment.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Ana Lago-Sampedro, Ailec Ho-Plagaro, Sara Garcia-Serrano, Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Carlos Lopez-Gomez, Flores Martin-Reyes, Gonzalo Ruiz-Aldea, Guillermo Alcain-Martinez, Montserrat Gonzalo, Custodia Montiel-Casado, Jose R. Fernandez, Eduardo Garcia-Fuentes, Francisca Rodriguez-Pacheco
Summary: The study revealed that oleic acid plays a role in restoring the circadian rhythm of clock genes in intestinal tissues of obese patients, influencing their behavior.
CLINICAL NUTRITION
(2021)
Review
Clinical Neurology
Ramon C. Hermida, Artemio Mojon, Ramon G. Hermida-Ayala, Michael H. Smolensky, Jose R. Fernandez
Summary: The evidence suggests that elevated asleep blood pressure and blunted sleep-time relative blood pressure decline are significant independent prognostic markers of cardiovascular disease risk. Treating hypertension at bedtime/evening instead of upon-waking/morning schedule produces better clinical benefits. Current guidelines do not adequately address this issue.
SLEEP MEDICINE REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Ramon C. Hermida, Ramon G. Hermida-Ayala, Michael H. Smolensky, Artemio Mojon, Jose R. Fernandez
Summary: Current research suggests that taking hypertension medications at bedtime is more beneficial than taking them in the morning, leading to better reduction of asleep blood pressure, decreased cardiovascular disease risk, and improved organ function.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biology
Ramon C. Hermida, Artemio Mojon, Jose R. Fernandez, Ramon G. Hermida-Ayala, Juan J. Crespo, Maria T. Rios, Manuel Dominguez-Sardina, Alfonso Otero, Michael H. Smolensky
Summary: Elevated asleep blood pressure and blunted sleep-time relative systolic blood pressure decline are significant prognostic markers of cardiovascular disease risk. Current hypertension guidelines overlook the importance of asleep blood pressure and recommend diagnosis based on office blood pressure measurements. Studies have shown that taking blood pressure-lowering medications at bedtime results in greater reduction of blood pressure and improved cardiovascular outcomes compared to morning intake.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Review
Biology
Ramon C. Hermida, Ramon G. Hermida-Ayala, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
Summary: Taking hypertension medications at bedtime/evening rather than upon-waking/morning can lead to significant benefits, such as reduced mean asleep blood pressure, decreased cardiovascular risk, improved kidney function, and reduced cardiac pathology. However, some past trials have inconsistent results mainly due to disparities and deficiencies in investigative protocols.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Editorial Material
Peripheral Vascular Disease
Ramon C. Hermida, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
Review
Biology
Ramon G. Hermida-Ayala, Artemio Mojon, Jose R. Fernandez, Michael H. Smolensky, Ramon C. Hermida
Summary: Research shows that taking dual-combination hypertension medications at bedtime/evening can lead to more significant benefits, including reduced asleep blood pressure, decreased prevalence of non-dipping blood pressure, fewer adverse effects, improved kidney function, and reduced cardiac pathology, compared to taking them upon waking/morning.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ramon C. Hermida, Diana E. Ayala, Artemio Mojon, Michael H. Smolensky, Juan J. Crespo, Alfonso Otero, Manuel Dominguez-Sardina, Ana Moya, Maria T. Rios, Maria C. Castineira, Pedro A. Callejas, Lorenzo Pousa, Elvira Sineiro, Jose L. Salgado, Carmen Duran, Juan J. Sanchez, Jose R. Fernandez
Summary: The study found that ABPM outperforms traditional OBPM in predicting cardiovascular disease outcomes, and can be used to replace in-clinic SBP measurements for improved accuracy. Using asleep systolic BP mean and sleep-time relative SBP decline as ABPM-derived predictive factors significantly enhanced the calibration, diagnostic accuracy, discrimination, and performance of the CVD risk stratification model.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Letter
Cardiac & Cardiovascular Systems
Ramon C. Hermida, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Review
Clinical Neurology
Michael H. Smolensky, Ami P. Shah, Jose R. Fernandez, Linda Sackett-Lundeen, Ramon C. Hermida
Summary: The aim of this study was to substantiate the 24-hour pattern in the occurrence of childhood febrile seizures (CFSs) and discuss its potential circadian rhythm-dependencies. Eight articles were included in a comprehensive search of the literature, with a total of 2461 CFSs cases from different countries. A 24-hour pattern in the onset of CFSs was validated, with the highest proportion occurring at 18:04 and the lowest at 06:00. The time-of-day risk of CFSs is likely influenced by multiple circadian rhythms, including cytokines and melatonin.
Review
Biology
Ramon C. Hermida, Michael H. Smolensky, Artemio Mojon, Jose R. Fernandez
Summary: The research on molecular and laboratory animal circadian rhythm has greatly increased in the past few decades. However, the lack of formal training and expertise in human circadian rhythm research among investigators conducting translational circadian medicine trials has led to deficient design and questionable findings. This has caused unnecessary controversy and hindered advances in patient care. Overall rating: 7/10
CHRONOBIOLOGY INTERNATIONAL
(2023)
Correction
Biology
Ramon C. Hermida, Ramon G. Hermida-Ayala, Artemio Mojon, Michael H. Smolensky, Jose R. Fernandez
CHRONOBIOLOGY INTERNATIONAL
(2021)