Journal
CHROMOSOME RESEARCH
Volume 21, Issue 1, Pages 27-36Publisher
SPRINGER
DOI: 10.1007/s10577-012-9335-7
Keywords
Centromeres; Chromosomes; Chromatin; Centromere protein A; Epigenetics
Funding
- CIHR [MOP-106548]
- CCSRI [700824]
Ask authors/readers for more resources
The Centromere is a unique chromosomal locus where the kinetochore is formed to mediate faithful chromosome partitioning, thus maintaining ploidy during cell division. Centromere identity is inherited via an epigenetic mechanism involving a histone H3 variant, called centromere protein A (CENP-A) which replaces H3 in centromeric chromatin. In spite of extensive efforts in field of centromere biology during the past decade, controversy persists over the structural nature of the CENP-A-containing epigenetic mark, both at nucleosomal and chromatin levels. Here, we review recent findings and hypotheses regarding the structure of CENP-A-containing complexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available