Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

(2011) Keisuke Kataoka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors

(2010) C. Cattoglio et al.   BLOOD

Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action

(2010) Jamal Tazi et al.   FEBS Journal

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

(2010) Stefan Stein et al.   NATURE MEDICINE

Chromosome Territories

(2010) T. Cremer et al.   Cold Spring Harbor Perspectives in Biology

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy

(2009) B. Cassani et al.   BLOOD

Nuclear neighborhoods and gene expression

(2009) Rui Zhao et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Transcriptional competence of the integrated HIV-1 provirus at the nuclear periphery

(2009) Mariacarolina Dieudonné et al.   EMBO JOURNAL

Molecular bases of myelodysplastic syndromes: Lessons from animal models

(2009) Yukiko Komeno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells

(2009) Marita Bosticardo et al.   MOLECULAR THERAPY

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

(2009) Ute Modlich et al.   MOLECULAR THERAPY

Transcription Factor Binding Sites Are Genetic Determinants of Retroviral Integration in the Human Genome

(2009) Barbara Felice et al.   PLoS One

The Meaning of Gene Positioning

(2008) Takumi Takizawa et al.   CELL

Chromatin Dynamics and Gene Positioning

(2008) R. Ileng Kumaran et al.   CELL

Three-dimensional positioning of genes in mouse cell nuclei

(2008) Claudia Hepperger et al.   CHROMOSOMA

Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP

(2008) T. Takizawa et al.   GENES & DEVELOPMENT

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

(2008) U Modlich et al.   LEUKEMIA

The MDS1–EVI1 Gene Complex as a Retrovirus Integration Site: Impact on Behavior of Hematopoietic Cells and Implications for Gene Therapy

(2008) Jean-Yves Métais et al.   MOLECULAR THERAPY

Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1

(2007) Leopoldo Laricchia-Robbio et al.   BLOOD CELLS MOLECULES AND DISEASES