Graphene as Solid-Phase Extraction Adsorbent for CZE Determination of Sulfonamide Residues in Meat Samples

A solid-phase extraction (SPE) using graphene as adsorbent coupled with capillary zone electrophoresis method was developed for the determination of four sulfonamide residues (sulfadimidine, sulfadimethoxine, sulfathiazole and sulfadiazine) in meat sample. Several condition parameters, such as elution solvents and volumes, sample pH and sample volume were optimized to obtain high SPE recoveries and extraction efficiency. Intra-day precisions of sulfonamides were in the range of 2.5-2.6 % and the inter-day precisions of sulfonamides were in the range of 2.6-3.4 %. Recoveries were 60.9-66.6 % for sulfadiazine and 86.1-111.4 % for other three sulfonamides in spiked meat sample. The developed method was successfully applied for the determination of sulfonamides in meat samples.