Journal
CHROMATOGRAPHIA
Volume 73, Issue 9-10, Pages 1009-1014Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10337-010-1897-y
Keywords
Capillary electrophoresis; Enantioseparation; Hydroxypropyl-gamma-cyclodextrin; Iodiconazole; Triadimenol analogue
Funding
- National Natural Science Foundation of China [81072614]
- Doctoral Innovation Foundation of Second Military Medical University, China
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Chiral separation of iodiconazole, a new antifungal drug, and 12 new structurally related triadimenol analogues were studied by capillary electrophoresis with seven neutral cyclodextrins. It was found that hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) was the most effective chiral selector. Furthermore, the influence of the concentration of HP-gamma-CD, buffer pH, buffer concentration, temperature, and applied voltage was investigated, and the method was validated. The study of the analyte structure-enantioseparation relationships showed that substitutions in the side chains had important influences on enantiomeric separation.
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