Journal
CHIRURGIE DE LA MAIN
Volume 31, Issue 6, Pages 311-317Publisher
ELSEVIER
DOI: 10.1016/j.main.2012.10.167
Keywords
Scar inhibition; Peripheral nerve; Regeneration; Collagen polymer; Vein graft
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The effects of a collagen membrane and a technique of autologous vein wrapping on scar formation after peripheral nerve suture are investigated. Forty-eight sciatic nerves from Wistar rats were transected and repaired, then allocated to a control group C (n = 16) and two experimental groups: in group A (n = 16) the repair line was covered by the collagen membrane, and in group B (n = 16) the repair line was wrapped by an external jugular venous graft. Three months later, it was observed that adhesions in the surrounding tissues were significantly less in groups A and B compared to group C, and significantly less in group A than in the group B. Histological analysis revealed no significant reduction of extraneural or intraneural scar tissue in groups A or B compared to group C. However intraneural fibrosis was significantly less in the group A than in the group B. It was concluded that the collagen membrane was effective in reducing neural scar formation after peripheral nerve suture. Autologous vein wrapping also showed a favorable effect in this indication despite less successful histological outcomes. (C) 2012 Published by Elsevier Masson SAS.
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