Review
Biotechnology & Applied Microbiology
Fei Fan, Sanjoy Saha, Donny Hanjaya-Putra
Summary: Hydrogels play a crucial role in wound healing by supporting a hydrated environment and promoting better healing outcomes through the incorporation of biomolecules and supporting cells. Various types of hydrogels have been developed and modified to match different stages of wound healing, with challenges related to adoption and future perspectives discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Immunology
Takahiro Manabe, Heamin Park, Takashi Minami
Summary: Wound healing is a complex process involving multiple cell types and signaling pathways, which can be easily impaired or dysregulated by the microenvironment, leading to the occurrence of various diseases. The calcium signaling pathway plays an important regulatory role in wound healing, affecting the progress of various healing steps.
INFLAMMATION AND REGENERATION
(2021)
Article
Cell & Tissue Engineering
Yu-Jin Kim, Hye Ran Jeon, Sung-Won Kim, Yeong Hwan Kim, Gwang-Bum Im, Jisoo Im, Soong Ho Um, Sung Min Cho, Ju-Ro Lee, Han Young Kim, Yoon Ki Joung, Dong-Ik Kim, Suk Ho Bhang
Summary: Research has shown that red OLED-based PBM can enhance the therapeutic efficacy of hADSCs, promoting angiogenesis, cell adhesion, and migration capabilities. This enhancement is attributed to the increase in intracellular reactive oxygen species levels, leading to accelerated healing and regulated inflammatory response in mice transplanted with hADSCs exposed to red light.
JOURNAL OF TISSUE ENGINEERING
(2021)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell & Tissue Engineering
Andreas Kerstan, Kathrin Dieter, Elke Niebergall-Roth, Sabrina Klingele, Michael Junger, Christoph Hasslacher, Georg Daeschlein, Lutz Stemler, Ulrich Meyer-Pannwitt, Kristin Schubert, Gerhard Klausmann, Titus Raab, Matthias Goebeler, Korinna Kraft, Jasmina Esterlechner, Hannes M. Schroder, Samar Sadeghi, Seda Ballikaya, Martin Gasser, Ana M. Waaga-Gasser, George F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter-Kochanek, Markus H. Frank, Mark A. Kluth
Summary: This study suggests that GMP-manufactured ABCB5(+) dermal mesenchymal stem cells might be a safe adjunctive therapy for incurable diabetic foot ulcers. The results from mouse models and clinical trials demonstrate the efficacy of these stem cells in promoting wound healing and restoring blood perfusion.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Review
Dermatology
Ken Natsuga, Satoru Shinkuma, Chao-Kai Hsu, Yasuyuki Fujita, Akira Ishiko, Katsuto Tamai, John A. McGrath
Summary: Epidermolysis bullosa (EB) is a group of inherited disorders caused by mutations in genes encoding basement membrane zone (BMZ) components or proteins maintaining the integrity of BMZ and adjacent keratinocytes. Research on blister wound healing in EB and advancements in gene therapy, read-through therapy, and cell therapy offer optimism for improved clinical management of EB patients. Progress in understanding disease mechanisms using human skin samples, animal models, and cultured cells is leading to the development of more effective therapeutics.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Cell Biology
Jiachao Xiong, Hong Qiang, Ting Li, Jiayi Zhao, Ziyu Wang, Fei Li, Jianwen Xu
Summary: The study demonstrates that human adipose-derived stem cells can promote the vascularization of seawater-treated wounds by differentiating into vascular endothelial cells and promoting their proliferation and migration. Bioinformatics analysis identified genes that may regulate wound healing mechanisms such as extracellular matrix remodeling, programmed cell death, inflammation, and vascularization.
Review
Anatomy & Morphology
Sana Ullah, Sumaiya Mansoor, Aaima Ayub, Momina Ejaz, Hajrah Zafar, Fizza Feroz, Ayyaz Khan, Muhammad Ali
Summary: Burn wounds can have long-lasting devastating effects on the human body, and conventional therapies are often ineffective at completely healing them. Stem cells have shown promising potential in promoting healing of burn wounds, offering advantages such as faster healing, reduced inflammation, and scar progression, making them a potential more efficient alternative to current treatments.
Review
Pharmacology & Pharmacy
Jitao Chen, Penghui Ye, Rifang Gu, Huan Zhu, Wenjie He, Xingrui Mu, Xingqian Wu, Huiwen Pang, Felicity Han, Xuqiang Nie
Summary: This paper reviews the regulatory characteristics of neuropeptide substance P (SP) in normal and diabetic wound healing. SP actively regulates wound healing-related cells, exhibiting strong inflammatory properties, promoting cell proliferation and migration, and restoring skin cell activity and paracrine ability under diabetic conditions. Additionally, SP not only regulates healing-related cells but also orchestrates the immune environment, presenting unique and promising application prospects in wound intervention, particularly for diabetic foot ulcers (DFU) treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Guoqiang Ren, Qiuyue Peng, Jeppe Emmersen, Vladimir Zachar, Trine Fink, Simone R. Porsborg
Summary: Adipose-derived Stem cells (ASCs) are about to be used in large-scale clinical trials for wound healing. It is important to develop potency assays for advanced therapy medicinal products (ATMPs) to ensure product consistency. Through analyzing ASC-based ATMPs from different donors, we found that certain regulatory genes associated with extracellular matrix and angiogenesis could be used as markers to select superior ASC donors for treating chronic wounds.
Article
Biochemistry & Molecular Biology
Seong-Ho Han, Dong-Sik Chae, Sung-Whan Kim
Summary: In this study, enhanced therapeutic potential of amniotic mesenchymal stem cells (AMM) was investigated through dual CXCR4/IL-10 gene knock-in insertion, leading to accelerated wound healing, high angiogenic effects, and anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Na Liu, Ziyi Zhou, Xuchao Ning, Xiaopei Zhang, Qingxia Guo, Mingxia Guo, Yuanfei Wang, Tong Wu
Summary: The interaction between electrospinning nanomaterials and stem cells has been studied for repairing damaged tissue. The focus is on manipulating cell behavior through materials and their specific topology. Nanofiber-based meshes have been tested and found to regulate the paracrine of adipose stem cells, influencing migration and angiogenesis. In vivo investigations using rat skin wound healing models also showed promising results in wound closure and collagen production.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Chang Sik Pak, Chan Yeong Heo, Jisoo Shin, Soo Young Moon, Seung-Woo Cho, Hyo Jin Kang
Summary: The combination of HA-CA and ADSCs showed synergistic effects in diabetic wound healing, providing significant healing effects by maximizing paracrine signaling and angiogenesis. This combination might represent a novel strategy for the treatment of diabetic wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Qirong Li, Dongxu Wang, Ziping Jiang, Rong Li, Tianyi Xue, Chao Lin, Yongzhi Deng, Ye Jin, Baozhen Sun
Summary: Wound healing is a complex process influenced by multiple factors. Chronic wounds, especially diabetic wounds and burns, pose a significant challenge for medical research. Hydrogels, as wound dressings, play an important role in chronic wound treatment due to their good biocompatibility and moisturizing effect. Stem cells have emerged as a promising approach for chronic wound healing, and the combination of stem cells and hydrogel offers great potential in this field.
FRONTIERS IN CHEMISTRY
(2022)
