NIR-VCD, Vibrational Circular Dichroism in the Near-Infrared: Experiments, Theory and Calculations

The first well documented experiments of Near Infrared Vibrational Circular Dichroism (NIR-VCD) were performed around 1975. We review the thirty year history of NIR-VCD, encompassing both instrumental development and theoretical/computational methods that allow interpretation of experimental spectra, harvesting useful structural information therefrom. We hope to stimulate interest in this still scarcely explored spectroscopy of chiral molecules. Chirality 21:E242-E252, 2009. (C) 2009 Wiley-Liss, Inc.