4.2 Article

Purple membrane resists cell adhesion

Journal

CHINESE SCIENCE BULLETIN
Volume 57, Issue 2-3, Pages 234-236

Publisher

SCIENCE PRESS
DOI: 10.1007/s11434-011-4904-2

Keywords

bacteriorhodopsin; purple membrane; cell adhesion; non-fouling; biomaterials

Funding

  1. National Basic Research Program of China [2009CB930000, 2011CB606203]
  2. National Natural Science Foundation of China [21034002]

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Bacteriorhodopsin is a well-known photoresponsive protein in the cell membrane of Halobacterium salinarum and exists in the patch called the purple membrane (PM). This letter reports, for the first time, its new function as a natural non-fouling substance for resisting cell adhesion. Mammalian cells such as murine preosteocytes MC3T3-E1 were seeded on the PM film. A significant resistance to cell adhesion on the film was found.

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