Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 14, Pages 4279-4283Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201410555
Keywords
gadolinium; imaging agents; kinetics; mass spectrometry; biochemistry
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Funding
- Ministry of Education and Research of the Federal Republic of Germany (BMBF) [01IB10004E, 01ZX1310B]
- Deutsche Forschungsgemeinschaft [HO 1258/3-1, SFB 824 TP Z02, WA 1656/3-1, WI 3686/4-1]
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Gadolinium(III)-based contrast agents improve the sensitivity and specificity of magnetic resonance imaging (MRI), especially when targeted contrast agents are applied. Because of nonlinear correlation between the contrast agent concentration in tissue and the MRI signal obtained in vivo, quantification of certain biological or pathophysiological processes by MRI remains a challenge. Up to now, no technology has been able to provide a spatially resolved quantification of MRI agents directly within the tissue, which would allow a more precise verification of in vivo imaging results. MALDI imaging mass spectrometry for spatially resolved in situ quantification of gadolinium(III) agents, in correlation to in vivo MRI, were evaluated. Enhanced kinetics of Gadofluorine M were determined dynamically over time in a mouse model of myocardial infarction. MALDI imaging was able to corroborate the in vivo imaging MRI signals and enabled in situ quantification of the gadolinium probe with high spatial resolution.
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