Combinatorial Library Based Engineering ofCandida antarcticaLipase A for Enantioselective Transacylation ofsec-Alcohols in Organic Solvent

Investigation of the Impact of Water on the Enantioselectivity Displayed by CALB in the Kinetic Resolution of δ-Functionalized Alkan-2-ol Derivatives

(2014) Bin Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Protein engineering for development of new hydrolytic biocatalysts

(2014) Mikael Widersten   CURRENT OPINION IN CHEMICAL BIOLOGY

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

(2013) John A. McIntosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalysis enters a new era

(2013) Nicholas J Turner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A high-throughput assay for the determination of acyltransferase activity of lipase CAL-A

(2013) Janett Müller et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Laboratory Evolution of Enantiocomplementary Candida antarctica Lipase B Mutants with Broad Substrate Scope

(2013) Qi Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Many Pathways in Laboratory Evolution Can Lead to Improved Enzymes: How to Escape from Local Minima

(2012) Yosephine Gumulya et al.   CHEMBIOCHEM

Directed enzyme evolution: beyond the low-hanging fruit

(2012) Moshe Goldsmith et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Combined Enzyme and Transition-Metal Catalysis for Dynamic Kinetic Resolutions

(2012) Rocío Marcos et al.   ISRAEL JOURNAL OF CHEMISTRY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

Biocatalytic synthesis of optically active tertiary alcohols

(2011) Robert Kourist et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dynamic Kinetic Resolution of a Wide Range of Secondary Alcohols: Cooperation of Dicarbonylchlorido(pentabenzylcyclopentadienyl)ruthenium and CAL-B

(2011) Mari Päiviö et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Combinatorial reshaping of the Candida antarctica lipase A substrate pocket for enantioselectivity using an extremely condensed library

(2011) A. G. Sandstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates

(2010) Jared C. Lewis et al.   CHEMBIOCHEM

Lipases for use in industrial biocatalysis: Specificity of selected structural groups of lipases

(2010) Sangeeta Naik et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Directed Evolution of an Enantioselective Lipase with Broad Substrate Scope for Hydrolysis of α-Substituted Esters

(2010) Karin Engström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iterative Saturation Mutagenesis Accelerates Laboratory Evolution of Enzyme Stereoselectivity: Rigorous Comparison with Traditional Methods

(2010) Manfred T. Reetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Finding better protein engineering strategies

(2009) Romas J Kazlauskas et al.   Nature Chemical Biology

Directed evolution of Candida antarctica lipase A using an episomaly replicating yeast plasmid†

(2009) Anders G. Sandström et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Enzyme engineering for enantioselectivity: from trial-and-error to rational design?

(2009) Linda G. Otten et al.   TRENDS IN BIOTECHNOLOGY

X-ray Structure of Candida antarctica Lipase A Shows a Novel Lid Structure and a Likely Mode of Interfacial Activation

(2007) Daniel J. Ericsson et al.   JOURNAL OF MOLECULAR BIOLOGY