Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression

(2015) F. Junker et al.   BLOOD

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Cutting Edge: Generation of Effector Cells That Localize to Mucosal Tissues and Form Resident Memory CD8 T Cells Is Controlled by mTOR

(2014) Ryan T. Sowell et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

(2014) Emily B Heikamp et al.   NATURE IMMUNOLOGY

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system

(2013) C. Sinclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of rapamycin

(2012) Robert J. Salmond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of p70S6K1-mediated Phosphorylation of eIF4B and PDCD4 Proteins in the Regulation of Protein Synthesis

(2012) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression

(2011) E. Stagakis et al.   ANNALS OF THE RHEUMATIC DISEASES

The influence of mTOR on T helper cell differentiation and dendritic cell function

(2011) Robert J. Salmond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

How does the mammalian target of rapamycin (mTOR) influence CD8 T-cell differentiation?

(2010) Robert J. Salmond et al.   CELL CYCLE

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Translational control of the innate immune response through IRF-7

(2008) Rodney Colina et al.   NATURE