Journal
JOURNAL OF IMMUNOLOGY
Volume 196, Issue 1, Pages 207-216Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1501582
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Funding
- Medical Research Council [MR/J001856/1]
- Institute Strategic Programme from the Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0409]
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0407, BBS/E/B/0000M985, BBS/E/B/000C0409] Funding Source: researchfish
- BBSRC [BBS/E/B/000C0409, BBS/E/B/000C0407] Funding Source: UKRI
- MRC [MR/J001856/1] Funding Source: UKRI
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An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell mediated diseases.
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