Article
Immunology
Xinyue Wang, Di Wang, Juan Du, Yuqing Wei, Rui Song, Beibei Wang, Shuang Qiu, Bei Li, Leidan Zhang, Yongqin Zeng, Hongxin Zhao, Yaxian Kong
Summary: Aging leads to immune system dysfunction, particularly T cell defects. CD244 plays a significant role in T cell aging, while CD160 does not. Therefore, CD244 may serve as a therapeutic target for improving diseases and comorbidities associated with immune system aging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Songpon Getsuwan, Nopporn Apiwattanakul, Chatmanee Lertudomphonwanit, Suradej Hongeng, Sophida Boonsathorn, Wiparat Manuyakorn, Pornthep Tanpowpong, Usanarat Anurathapan, Kanchana Tangnararatchakit, Suporn Treepongkaruna
Summary: This study aimed to investigate CMV-specific T cell immune reconstitution among pediatric LT recipients. The results showed that despite intense immunosuppressive therapy, CMV-specific T cell immune reconstitution occurred in pediatric patients post-LT, which could confer protection against CMV reactivation.
Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Aafke A. Duizendstra, Michelle V. van der Grift, Patrick P. Boor, Lisanne Noordam, Robert J. de Knegt, Maikel P. Peppelenbosch, Michiel G. H. Betjes, Nicolle H. R. Litjens, Jaap Kwekkeboom
Summary: This study validates the differential expression of immune system-related genes in tolerant liver transplant recipients. The use of immunosuppressive drugs and previous cytomegalovirus infection confound the expression of these genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiao Bing Liu, Hui Liu, Jiang Liu, Allen Ka Loon Cheung, Ming Zhu Zheng, Jin Lin Cheng, Qing Sheng Liu, Chung Mau Lo, Zhi Wei Chen, Kwan Man
Summary: This study investigated the effects of cytomegalovirus (CMV) latency on small-for-size graft injury and the pathogenic role of hepatic stellate cells (HSCs) in this process. The study found that CMV latency aggravated early and late phase liver graft damage and fibrogenesis via the CCL19/CCR7/HSCs axis.
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Review
Immunology
Sara Alonso-Alvarez, Enrique Colado, Marco A. Moro-Garcia, Rebeca Alonso-Arias
Summary: The intricate relationship between herpesvirus and humans has evolved over millions of years, resulting in a low level of viral activity due to latency. This balance is disrupted in immunosuppressed patients, particularly those with hematologic disorders. New treatment modalities have shed light on the role of various immune cells and the impact of CMV infection in different patient groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Marko Sustic, Maja Cokaric Brdovcak, Astrid Krmpotic, Stipan Jonjic
Summary: The 20th century saw a significant increase in the number of vaccines used to combat diseases caused by viral and bacterial pathogens. However, major public health threats such as HIV, tuberculosis, malaria, and cancer continue to pose a significant burden. CD8 T cells have emerged as promising candidates for vaccine targeting, playing a key role in protection against pathogens and tumors.
Article
Immunology
Marion Griessl, Angelique Renzaho, Kirsten Freitag, Christof K. Seckert, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: This study investigated the transcription of viral genes during latent infection of murine cytomegalovirus, revealing that the transcription of antigenic peptides driving memory inflation rarely coincides with the transcription of immune evasion proteins. The stochastic transcription hypothesis explains why immune evasion does not interfere with memory inflation in latently infected cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Marie Le Moine, Abdulkader Azouz, Guillem Sanchez Sanchez, Solange Dejolier, Muriel Nguyen, Severine Thomas, Valdrin Shala, Hacene Dreidi, Sebastien Denanglaire, Frederick Libert, David Vermijlen, Fabienne Andris, Stanislas Goriely
Summary: The co-inhibitory programmed death (PD)-1 signaling pathway has a crucial role in tumor-specific T cell responses as well as peripheral tolerance. This study reveals the involvement of PD-1 signaling in liver memory T cell homeostasis through the preferential expansion of CD8+ T cells with oligoclonal TCR repertoire and terminally differentiated exhaustion profile. The transcription factor EOMES is found necessary for the clonal expansion and acquisition of this differentiation program.
Article
Oncology
Po-Jung Hsu, Hao-Chien Hung, Jin-Chiao Lee, Yu-Chao Wang, Chih-Hsien Cheng, Tsung-Han Wu, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan, Wei-Chen Lee, Chen-Fang Lee
Summary: This study investigated the impact of CMV on tumor recurrence in HCC patients undergoing liver transplantation. Patients with positive CMV antigenemia had a significantly better 5-year recurrence-free survival, but no significant difference in overall survival. More CMV-negative patients died from HCC recurrence, while more CMV-positive patients died from other infections.
Article
Immunology
Kerstin M. Gergely, Juergen Podlech, Sara Becker, Kirsten Freitag, Steffi Krauter, Nicole Buescher, Rafaela Holtappels, Bodo Plachter, Matthias J. Reddehase, Niels A. W. Lemmermann
Summary: The study demonstrates that combining ACT and TherVac in HCT recipients significantly improves antiviral control, and the enhancement of antiviral protection through vaccination is strictly epitope-specific.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bin Cui, Jie Sun, Shi-Peng Li, Guang-Peng Zhou, Xiao-Jie Chen, Li-Ying Sun, Lin Wei, Zhi-Jun Zhu
Summary: This study reveals that CD80(+) DCs derived exosomes negatively regulate CD8(+) T cells via inhibition of NLRP3 expression, which attenuates acute LT rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Iris N. Pardieck, Suzanne van Duikeren, Dominique M. B. Veerkamp, Dena J. Brasem, Anke Redeker, Jeroen van Bergen, Wanda Han, Ferry Ossendorp, Gerben Zondag, Ramon Arens
Summary: This study suggests that the addition of antiviral T cell responses to antibody-eliciting vaccines can enhance immunity to human cytomegalovirus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Sara Hamdan, Matthias J. Reddehase, Rafaela Holtappels
Summary: Cytomegalovirus (CMV) infections have conflicting hallmarks. Immune evasion proteins raise the avidity threshold for activation, allowing only high-avidity cells to provide protection.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Gilles S. van Tienderen, Oskar Rosmark, Ruby Lieshout, Jorke Willemse, Floor de Weijer, Linda Elowsson Rendin, Gunilla Westergren-Thorsson, Michail Doukas, Bas Groot Koerkamp, Martin E. van Royen, Luc J. W. van der Laan, Monique M. A. Verstegen
Summary: Patient-derived tumor organoids were combined with native tumor and liver scaffolds through decellularization to study the interaction between tumor cells and the extracellular matrix (ECM). The use of decellularized scaffolds resulted in a more accurate representation of the in vivo tumor environment and increased chemoresistance. This method also revealed environment-dependent proliferation dynamics and stimulated the production of collagen types.
ACTA BIOMATERIALIA
(2023)
Letter
Hematology
Cilia R. Pothast, Kayleigh van Dijk, Emma S. Pool, Constantijn J. M. Halkes, Mirjam H. M. Heemskerk, Jennifer M. -L. Tjon
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Ruby Lieshout, Eline J. C. A. Kamp, Monique M. A. Verstegen, Michail Doukas, Winand N. M. Dinjens, Kubra Koten, Jan N. M. IJzermans, Marco J. Bruno, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Annemarie C. de Vries
Summary: This study reveals that primary sclerosing cholangitis (PSC)-related cholangiocarcinoma (CCA) cells have a higher proliferation rate compared to sporadic CCA cells. The cytokine IL-17A, which is related to inflammation, stimulates the proliferation of CCA cells and may contribute to the high proliferation rate in PSC-CCA. IL-17A represents a potential therapeutic target for (PSC-)CCA.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Janina Eden, Richard Xavier Sousa Da Silva, Miriam Cortes-Cerisuelo, Kristopher Croome, Riccardo De Carlis, Amelia J. Hessheimer, Xavier Muller, Femke de Goeij, Vanessa Banz, Giulia Magini, Philippe Compagnon, Andreas Elmer, Andrea Lauterio, Rebecca Panconesi, Jeannette Widmer, Daniele Dondossola, Paolo Muiesan, Diethard Monbaliu, Marieke de Rosner van van Rosmalen, Olivier Detry, Constantino Fondevila, Ina Jochmans, Jacques Pirenne, Franz Immer, Gabriel C. Oniscu, Jeroen de Jonge, Mickael Lesurtel, Luciano G. De Carlis, C. Burcin Taner, Nigel Heaton, Andrea Schlegel, Philipp Dutkowski
Summary: Liver graft utilization rates and discard rates vary across countries, with machine perfusion strategies contributing to better DCD utilization rates. Risk factors and use of various machine perfusion techniques vary between countries, but this does not significantly impact 5-year graft survival rates. Overall, countries with routine use of machine perfusion strategies have higher DCD utilization rates without compromised outcomes.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Luc J. W. van der Laan, Thijs Bosker, Willie J. G. M. Peijnenburg
Summary: A new report from the World Health Organization assesses the risks of dietary exposure to nanoplastic and microplastic particles. Although detecting these particles in food and beverages remains challenging, human exposure is evident. So far, there is no convincing evidence of adverse health effects, but significant knowledge gaps remain.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Surgery
Anne-Marleen van Keulen, Stefan Buttner, Joris I. Erdmann, Jeroen Hagendoorn, Frederik J. H. Hoogwater, Jan N. M. IJzermans, Ulf P. Neumann, Wojciech G. Polak, Jeroen De Jonge, Pim B. Olthof, Bas Groot Koerkamp
Summary: A systematic review and meta-analysis revealed that the risk of major complications and mortality after resection of intrahepatic cholangiocarcinoma was assessed. The study found that in-hospital, 30-day, and 90-day mortality rates were 5.9%, 4.6%, and 6.1% respectively, while the proportion of major complications was 22.2%.
Article
Medicine, General & Internal
Shaojun Shi, Henk P. Roest, Thierry P. P. van den Bosch, Marcel J. C. Bijvelds, Markus U. Boehnert, Jeroen de Jonge, Sven O. Dekker, Antoine A. F. de Vries, Hugo R. de Jonge, Monique M. A. Verstegen, Luc J. W. van der Laan
Summary: This study successfully replicated ischemic cholangiopathy in vitro using human intrahepatic cholangiocyte organoids stressed by ischemia and subsequent re-oxygenation. The model exhibited similar changes in cell proliferation, epithelial-mesenchymal transition, and cell death processes as observed in patients. The research also identified alpha-1 antitrypsin as a potent inhibitor of ischemia-induced apoptosis and necroptosis.
Article
Gastroenterology & Hepatology
David M. de Jong, Sanne van de Vondervoort, Roy S. Dwarkasing, Michael Doukas, Rogier P. Voermans, Robert C. Verdonk, Wojciech G. Polak, Jeroen de Jonge, Bas Groot Koerkamp, Marco J. Bruno, Lydi M. J. W. van Driel
Summary: This study investigates the added value of preoperative endoscopic ultrasound (EUS) with or without tissue acquisition (TA) for the detection of MLNs in patients with resectable pCCA. The results show that EUS-TA can effectively detect MLNs and prevent unnecessary surgeries.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Oncology
Jessie S. Kroonen, Ilona J. de Graaf, Sumit Kumar, Dennis F. G. Remst, Anne K. Wouters, Mirjam H. M. Heemskerk, Alfred C. O. Vertegaal
Summary: Combination therapies using SUMO inhibition and DNA hypomethylation can effectively reduce cell proliferation in MYC-driven hematopoietic malignancies. In vivo experiments also showed promising results in reducing tumor growth with the combined treatment. Tailored combination therapies based on molecular mechanisms have the potential to improve cancer treatment efficacy.
Review
Immunology
Marjolein J. M. ten Dam, Geert W. J. Frederix, Renske M. T. ten Ham, Luc J. W. van der Laan, Kerstin Schneeberger
Summary: Due to a shortage of suitable donor livers, alternative treatments for end-stage liver disease need to be explored. Recent advances in organoid technology show potential for cell therapy and tissue engineering approaches as a solution.
Article
Immunology
Ruslan A. Mammadov, Jasmijn W. Selten, Henk P. Roest, Cornelia J. Verhoeven, Luca Maroni, Sandra I. Bril, Dagmar Tolenaars, Pravesh S. Gadjradj, Stan F. J. van de Graaf, Ronald P. J. Oude Elferink, Jaap Kwekkeboom, Herold J. Metselaar, Maikel P. Peppelenbosch, Ulrich Beuers, Jan N. M. IJzermans, Luc J. W. van der Laan
Summary: In this study, it was found that there is a potential link between intestinal bacteremia and rPSC after LT, which is related to the nonsecretor variant of the FUT2 gene.
Editorial Material
Immunology
Puck C. Groen, Jeroen de Jonge, Robert J. Porte
Article
Biochemistry & Molecular Biology
Jesper van Eck van der Sluijs, Diede van Ens, Jolanda Brummelman, Daan Heister, Aastha Sareen, Lisa Truijen, Dorette S. van Ingen Schenau, Mirjam H. M. Heemskerk, Marieke Griffioen, Michel G. D. Kester, Nicolaas P. M. Schaap, Joop H. Jansen, Anniek B. van der Waart, Harry Dolstra, Willemijn Hobo
Summary: Non-DCs have been found to enhance the activation and expansion of antigen-specific CD8+ T cells mediated by DCs, without impairing the NK cell responses in vitro and in vivo. This provides a rationale for further clinical translation of the CD34+-derived DC-complete vaccine in hemato-oncology patients post alloSCT.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
S. E. Kaffka Genaamd Dengler, M. T. Vervoorn, M. Brouwer, J. de Jonge, N. P. van der Kaaij
Summary: With an increasing number of heart failure patients awaiting transplantation, the demand for viable organs exceeds the supply. The use of hearts from circulatory death donors has helped alleviate this shortage. Different techniques exist for heart procurement in circulatory death donors, but ethical concerns have been raised regarding the specific use of thoraco-abdominal normothermic regional perfusion. This paper discusses the current dilemmas surrounding these heart procurement protocols.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Meeting Abstract
Immunology
I. J. Schurink, J. Willemse, S. H. Luijmes, F. H. de Goeij, P. C. Groen, E. H. Kucukerbil, M. M. Pascale, S. Shi, W. G. Polak, L. J. van der Laan, J. de Jonge