Article
Multidisciplinary Sciences
Johnny E. Elguero, Guangmei Liu, Katherine Tiemeyer, Shruthi Bandyadka, Heena Gandevia, Lauren Duro, Zhenhao Yan, Kimberly Mccall
Summary: This study found that Drosophila mutants lacking the phagocytic receptor Draper have phagocytic defects leading to neurodegenerative diseases. The study also discovered that phagocytic defects cause neurodegeneration through increased immune signaling.
Article
Rheumatology
Hanna Johnsson, John Cole, Iain B. McInnes, Gerard Graham, Stefan Siebert
Summary: This study compares transcriptional changes in psoriasis and PsA skin for the first time, finding that immunoglobulin genes are upregulated in PsA skin lesions, which may have implications for its spread to other tissues.
Article
Urology & Nephrology
Sarah Cormican, Neema Negi, Serika D. D. Naicker, Md Nahidul Islam, Barbara Fazekas, Rachael Power, Tomas P. Griffin, M. Conall Dennedy, Briain MacNeill, Andrew F. F. Malone, Matthew D. D. Griffin
Summary: Cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is associated with increased levels of intermediate monocytes (IMs). Dysregulation of monocyte maturation and function may contribute to cardiovascular complications in CKD. In this study, the authors examined monocyte subpopulations and found that HLA-DRhi IMs were increased in individuals with CKD. These IMs produced higher levels of proinflammatory cytokines and showed increased migration and adhesion to endothelial cells compared to other monocyte populations. Dysregulated monocyte maturation and function may be targeted to reduce accelerated CVD in CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Takahiro Kawasaki, Fuminori Sugihara, Kiyoharu Fukushima, Takanori Matsuki, Hiroshi Nabeshima, Tomohisa Machida, Yuichi Mitsui, Saki Fujimura, Rio Sagawa, Lee Gaheun, Kanako Kuniyoshi, Hiroki Tanaka, Masashi Narazaki, Atsushi Kumanogoh, Shizuo Akira, Takashi Satoh
Summary: The study demonstrates that FCHSD1 plays a crucial role in the pathogenesis of emphysema by inhibiting nuclear translocation of NRF2 and subsequently down-regulating SIRT1 levels, promoting the development of the disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Hanjiang Gu, Yufei Zhang, Weihui Zeng, Yumin Xia
Summary: Interferons play a crucial role in the pathogenesis of psoriasis by directly affecting skin resident cells, recruiting and modulating inflammatory cells, and exacerbating inflammation response.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Eva Reali, Davide Ferrari
Summary: Human skin acts as a protective organ with a complex architecture hosting various immune and non-immune cells that play crucial roles in immunological processes. Dysregulated or excessive immune responses can lead to autoimmune diseases, such as psoriasis. Understanding the mechanisms of psoriasis is important for developing targeted treatments and preventing severe systemic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sarah Adriana Scuderi, Laura Cucinotta, Alessia Filippone, Marika Lanza, Michela Campolo, Irene Paterniti, Emanuela Esposito
Summary: This study investigates the effect of melatonin on psoriatic phenotype and S. aureus infection-associated psoriasis using an in vitro model. The results demonstrate that melatonin reduces histological damage, restores tight-junction expression, and reduces pro-inflammatory cytokine levels. Melatonin may have potential as a promising strategy for treating psoriasis-like skin inflammation and complications of psoriasis, such as S. aureus infection.
Article
Biochemistry & Molecular Biology
Stephanie Tomasi, Lei Li, Ludwig Christian Hinske, Roland Tomasi, Martina Amini, Gabriele Strauss, Martin Bernhard Mueller, Simon Hirschberger, Sven Peterss, David Effinger, Kristin Pogoda, Simone Kreth, Max Huebner
Summary: During acute inflammation, the regulatory network driven by miR-125a affects monocyte adhesion and chemotaxis by directly targeting adhesion molecules and chemokine receptors. The levels of miR-125a are influenced by the type of inflammatory stimulus, which in turn strongly impacts the phenotype of human monocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lili Borbala Flink, Ameneh Ghaffarinia, Benjamin Tamas Papp, Akos Varga, Andras Istvan Vigh, Daniel Laszlo Vidacs, Robert Kui, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Renata Bozo
Summary: Psoriatic skin shows abnormal wound healing-like characteristics, even in non-lesional skin. Elevated levels of fibroblast-derived dermal periostin were observed in psoriatic patients, especially in those receiving systemic treatment. Basal keratinocytes in psoriatic skin exhibited significant periostin positivity, both in non-lesional, lesional, and previously-lesional areas. This abnormal wound healing-like phenotype with overexpression of periostin in psoriatic skin suggests a potential compensatory mechanism initiated by basal membrane injury, which can persist in healed skin.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope Blakely, Ayse Bilge Ozel, Sarah Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekmulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thorner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Soren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, Gunnar Engstroem, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Summary: This study investigated the pathogenic involvement of soluble urokinase plasminogen activator receptor (suPAR) in atherosclerosis. The researchers found that suPAR levels were predictive of coronary artery calcification and cardiovascular events. Through genetic analysis and experimental models, they identified a variant in the PLAUR gene that led to higher suPAR levels and confirmed a causal association between suPAR levels and atherosclerotic phenotypes. The study also found that suPAR affected monocyte function, leading to increased inflammation and chemotaxis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Facundo Di Diego Garcia, Gonzalo Cabrerizo, Ana Paletta, Paula S. Perez, Augusto Varese, Jorge Geffner, Natalia Bello, Vanesa Fridman, Daniel Stecher, Ana Ceballos, Federico Remes Lenicov
Summary: This study investigated the effects of prostaglandin E2 (PGE2) on monocyte activation in chronic HIV infection and the mechanisms through which PGE2 modulates their inflammatory signature. The results showed increased plasma levels of PGE2 and an activated phenotype in monocytes from people with HIV (PWH). Monocytes from PWH also exhibited resistance to the inhibitory actions mediated by PGE2, possibly contributing to their inflammatory profile.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Neurosciences
Sonia Sabate-Soler, Sarah Louise Nickels, Claudia Saraiva, Emanuel Berger, Ugne Dubonyte, Kyriaki Barmpa, Yan Jun Lan, Tsukasa Kouno, Javier Jarazo, Graham Robertson, Jafar Sharif, Haruhiko Koseki, Christian Thome, Jay W. Shin, Sally A. Cowley, Jens C. Schwamborn
Summary: The absence of microglia in current midbrain organoid systems limits the study of neuronal networks and neuroinflammation-related diseases. This study successfully derived microglia from human iPSCs and integrated them into midbrain organoids, shedding light on the role of microglia in influencing other cells in the organoids.
Article
Immunology
Arthur VanValkenburg, Vaishnavi Kaipilyawar, Sonali Sarkar, Subitha Lakshminarayanan, Chelsie Cintron, Senbagavalli Prakash Babu, Selby Knudsen, Noyal Mariya Joseph, C. Robert Horsburgh, Jerrold J. Ellner, Prakash Babu Narasimhan, W. Evan Johnson, Natasha S. Hochberg, Padmini Salgame
Summary: This study found that malnourished individuals with latent tuberculosis infection (LTBI) exhibit increased activation of inflammatory pathways and higher expression of risk signatures associated with progression to TB, compared to control individuals. These findings suggest the potential for TB risk biomarkers to identify malnourished LTBI individuals for targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Xuekai Xiong, Yayu Lin, Jeongkyung Lee, Antonio Paul, Vijay Yechoor, Mariana Figueiro, Ke Ma
Summary: Chronic shiftwork disrupts the circadian clock, resulting in adipocyte hypertrophy and adipose tissue inflammation and fibrosis in mice. This disruption also impairs insulin signaling and suppresses the mTOR pathway, highlighting a potential link between circadian misalignment and insulin resistance.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Chaobo Lai, Jennifer Heinemann, Ulrike Schleicher, Georg Schett, Christian Bogdan, Aline Bozec, Didier Soulat
Summary: Chronic infection with Leishmania increases bone mass by inducing bone formation and impairing osteoclast differentiation and function.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Letter
Dermatology
Valerie Horsley, Donald Glass, Rebecca Minnillo, Richard Gallo, Ponciano Cruz, Nicole L. Ward
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Letter
Dermatology
Divya Seth, Alexa N. Ehlert, Jackelyn B. Golden, Giovanni Damiani, Thomas S. McCormick, Mark Cameron, Kevin D. Cooper
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Review
Medicine, Research & Experimental
Yanyun Jiang, Lam C. Tsoi, Allison C. Billi, Nicole L. Ward, Paul W. Harms, Chang Zeng, Emanual Maverakis, J. Michelle Kahlenberg, Johann E. Gudjonsson
Letter
Dermatology
Jackelyn B. Golden, Brian Richardson, Divya Seth, Samantha Goldberg, Thomas S. McCormick, Kevin D. Cooper, Mark J. Cameron
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Dermatology
Wesley Y. Yu, Sheena T. Hill, E. Ricky Chan, John J. Pink, Kevin Cooper, Sancy Leachman, Amanda W. Lund, Rajan Kulkarni, Jeremy S. Bordeaux
Summary: Research suggests that statins may have potential in preventing melanoma metastasis, but prospective trials are needed to confirm the findings and determine the mechanism of metastasis prevention.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Dermatology
Pushpa Pandiyan, Thomas S. McCormick
Summary: This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and their involvement in cutaneous pathogenic responses. It also discusses cutaneous dysbiosis and the role of FOXP3(+) regulatory T cells in inflammatory conditions linked to IL-17 responses in the skin. Specifically, it reviews key literature on chronic mucocutaneous candidiasis and psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Dermatology
Di Yan, Johann E. Gudjonsson, Stephanie Le, Emanual Maverakis, Olesya Plazyo, Christopher Ritchlin, Jose U. Scher, Roopesh Singh, Nicole L. Ward, Stacie Bell, Wilson Liao
Summary: Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Recent advances in genetics, microbiology, immunology, and mouse models have shed light on the complex interplay between heritable and microenvironmental factors in driving psoriatic inflammation. These scientific advancements have paved the way for a more personalized approach to treating psoriatic disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David C. Soler, Amber Kerstetter-Fogle, Andrew B. Young, Pat Rayman, James H. Finke, Sarah M. Debanne, Kevin D. Cooper, Jill Barnholtz-Sloan, Andrew E. Sloan, Thomas S. McCormick
Summary: This study focused on human monocytic Myeloid-Derived Suppressor cells (Mo-MDSC) and identified Vanin-2 protein as a novel biomarker highly enriched in healthy individuals, but with an inverse correlation to grade in glioma patients. CD14(+)VNN2(high) monocytes may mark a monocytic population similar to Mo-MDSC only in healthy subjects, which could be useful for tumor diagnoses.
MOLECULAR IMMUNOLOGY
(2022)
Review
Dermatology
Roopesh Singh Gangwar, Johann E. Gudjonsson, Nicole L. Ward
Summary: This comprehensive review compares and discusses genetic mouse models, xenograft approaches, and cytokine injections and topical imiquimod application in mice for studying psoriasis. It provides a detailed description and outcomes of these models and methods, serving as a valuable resource for researchers interested in working with psoriasis animal models.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Giovanni Damiani, Joselin D. Tacastacas, Timothy Wuerz, Lindsay Miller, Philip Fastenau, Christopher Bailey, Mansi Sethi Chawa, Amanda Argenas, Marco Fiore, Kevin D. Cooper, Alan J. Lerner
Summary: This study found that CTCL and psoriasis may impact cognitive functioning, particularly in the domain of memory. Lower scores on executive function tests were predicted by worse HR-QOL scores. Higher estimated baseline intellectual functioning predicted better HR-QOL. Shorter disease duration may negatively impact memory and acute anxiety.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Dermatology
Megan V. Ha, Thomas S. McCormick, Iman Salem, Hilmi Al-Shakhshir, Mahmoud A. Ghannoum, Bryan T. Carroll
Summary: Solid organ transplant recipients have a higher risk of squamous cell carcinoma. Microbial dysbiosis may influence transplant outcomes. This study found that individuals with a history of squamous cell carcinoma have lower microbial diversity in the skin and gut. Microbial markers have potential for predicting squamous cell carcinoma risk in solid organ transplant recipients.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Sean M. Hughes, Claire N. Levy, Fernanda L. Calienes, Joanne D. Stekler, Urvashi Pandey, Lucia Vojtech, Alicia R. Berard, Kenzie Birse, Laura Noel-Romas, Brian Richardson, Jackelyn B. Golden, Michael Cartwright, Ann C. Collier, Claire E. Stevens, Marcel E. Curlin, Timothy H. Holtz, Nelly Mugo, Elizabeth Irungu, Elly Katabira, Timothy Muwonge, Javier R. Lama, Jared M. Baeten, Adam Burgener, Jairam R. Lingappa, M. Juliana McElrath, Romel Mackelprang, Ian McGowan, Ross D. Cranston, Mark J. Cameron, Florian Hladik
CELL REPORTS MEDICINE
(2020)