Journal
CHINESE JOURNAL OF PHYSIOLOGY
Volume 54, Issue 2, Pages 118-123Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4077/CJP.2011.AMM047
Keywords
GABA receptor; delta-opioid receptor; cortex; hypoxia
Categories
Funding
- NIH [HD-34852, AT-004422]
- American Heart Association, USA [AHA-0755993T]
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Recent studies show that both delta-opioid receptors (DOR) and GABA receptors play a neuroprotective role in the mature cortex. Since we have observed that DOR over-expression renders the cortex more tolerant to hypoxic stress, we asked whether DOR over-expression affects GABA receptors expression in the cortex under hypoxia. As the first step, we investigated the expression of GABA(A) receptor alpha 1-subunit (GABA(A) R alpha 1, the most abundant alpha-subunit of GABA receptors in the adult brain) in the mouse cortex with transgenic DOR over-expression after hypoxia. The results showed that GABA(A) R alpha 1 expression was lower in the transgenic than wild-type cortex, suggesting that DOR overexpression induces an inhibitory effect on GABA(A) receptor expression. Hypoxia for 1-3 days significantly increased GABA(A) R alpha 1 expression in the wild-type cortex, which may be an adaptive strategy for protecting the cortex against hypoxic stress. interestingly, such increase was not found in the transgenic cortex with DOR over-expression. This may represent an interactive regulation in the transgenic cortex to efficiently balance energy production and consumption for better adaptation to hypoxic environment. Since DOR over-expression increases cortical tolerance to hypoxia, an increase in GABA receptors expression (an energy-costing process) may not be necessary in the cortex with DOR over-expression.
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