Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

(2015) Isabella Rauch et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Intestinal Epithelial Stat3 Orchestrates Tissue Defense during Gastrointestinal Infection

(2015) Nadine Wittkopf et al.   PLoS One

Type I interferons have opposing effects during the emergence and recovery phases of colitis

(2014) Isabella Rauch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

(2014) Judith Behnsen et al.   IMMUNITY

Longitudinal study of murine microbiota activity and interactions with the host during acute inflammation and recovery

(2014) Clarissa Schwab et al.   ISME Journal

Inhibition of TYK2 and JAK1 Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis by Inhibiting IL-22 and the IL-23/IL-17 Axis

(2014) Melissa G. Works et al.   JOURNAL OF IMMUNOLOGY

FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units

(2014) et al.   LABORATORY ANIMALS

Citrobacter rodentium: infection, inflammation and the microbiota

(2014) James W. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance

(2014) Raimund M. Vielnascher et al.   TRANSGENIC RESEARCH

Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population

(2013) L.H. Lian et al.   GENETICS AND MOLECULAR RESEARCH

Deletion of Intestinal Epithelial Cell STAT3 Promotes T-Lymphocyte STAT3 Activation and Chronic Colitis Following Acute Dextran Sodium Sulfate Injury in Mice

(2013) Tara A. Willson et al.   INFLAMMATORY BOWEL DISEASES

Tyk2 is a therapeutic target for psoriasis-like skin inflammation

(2013) M. Ishizaki et al.   INTERNATIONAL IMMUNOLOGY

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

IL-22 Regulates Iron Availability In Vivo through the Induction of Hepcidin

(2013) C. L. Smith et al.   JOURNAL OF IMMUNOLOGY

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

(2013) S. J. Sohn et al.   JOURNAL OF IMMUNOLOGY

IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism

(2013) A Eken et al.   Mucosal Immunology

The role of the immune system in governing host-microbe interactions in the intestine

(2013) Eric M Brown et al.   NATURE IMMUNOLOGY

Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease

(2013) Mehmet Coskun et al.   PHARMACOLOGICAL RESEARCH

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice

(2013) Falk Hildebrand et al.   GENOME BIOLOGY

Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

(2012) David Berry et al.   ISME Journal

A Patient with Tyrosine Kinase 2 Deficiency without Hyper-IgE Syndrome

(2012) Sara S. Kilic et al.   JOURNAL OF PEDIATRICS

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

INTERLEUKIN-22 MODULATES GUT EPITHELIAL AND IMMUNE BARRIER FUNCTIONS FOLLOWING ACUTE ALCOHOL EXPOSURE AND BURN INJURY

(2012) Juan L. Rendon et al.   SHOCK

Activation of epithelial STAT3 regulates intestinal homeostasis

(2011) Clemens Neufert et al.   CELL CYCLE

Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice

(2011) M. Ishizaki et al.   INTERNATIONAL IMMUNOLOGY

A Novel Role for Interleukin-27 (IL-27) as Mediator of Intestinal Epithelial Barrier Protection Mediated via Differential Signal Transducer and Activator of Transcription (STAT) Protein Signaling and Induction of Antibacterial and Anti-inflammatory Proteins

(2011) Julia Diegelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Tyrosine Kinase-2 in Both the IL-12/Th1 and IL-23/Th17 Axes In Vivo

(2011) M. Ishizaki et al.   JOURNAL OF IMMUNOLOGY

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice

(2011) J H Cox et al.   Mucosal Immunology

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

(2011) Naruhisa Ota et al.   NATURE IMMUNOLOGY

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

(2010) Wendy S. Garrett et al.   Cell Host & Microbe

Interleukin-11 Reduces TLR4-Induced Colitis in TLR2-Deficient Mice and Restores Intestinal STAT3 Signaling

(2010) Deanna L. Gibson et al.   GASTROENTEROLOGY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis

(2009) A. Oyamada et al.   JOURNAL OF IMMUNOLOGY

Regulation of intestinal barrier function by signal transducer and activator of transcription 5b

(2008) X Han et al.   GUT

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Inflammatory bowel disease, past, present and future: lessons from animal models

(2008) Atsushi Mizoguchi et al.   JOURNAL OF GASTROENTEROLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Role of STAT3 in inflammatory bowel disease

(2008) Ken Sugimoto   WORLD JOURNAL OF GASTROENTEROLOGY