Article
Multidisciplinary Sciences
Zhiguo Li, Dongliang Yang, Yue Ge, Shu Song, Qin Lv, Yong'an Ye
Summary: The aim of this study was to establish a baseline rate of significant histologic changes and determine the main characteristics of immune-tolerant (IT) phase patients with chronic HBV infection. Based on the meta-analysis of 15 studies, the pooled rates of significant liver fibrosis and inflammatory activity among IT patients were 10% and 16% respectively. The pooled mean values of age, alanine aminotransferase level, HBV DNA level, and HBsAg level for IT patients diagnosed by dual criteria were also summarized.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Zhanqing Zhang, Wei Lu, Dan Huang, Xinlan Zhou, Rongrong Ding, Xiufen Li, Yanbing Wang, Weijia Lin, Dong Zeng, Yanling Feng
Summary: This study re-characterized the quantitative levels of HBsAg and HBV DNA in the natural history phases of chronic HBV infection. The results showed that HBsAg and HBV DNA had divergent abilities in predicting significant hepatitis activity in both HBeAg-positive and HBeAg-negative patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
T. Jake Liang
Summary: New strategies utilizing nucleic acid technologies are being explored for the treatment of chronic hepatitis B, with a pilot clinical study of antisense oligonucleotide treatment demonstrating the potential promise of this approach.
Review
Gastroenterology & Hepatology
Hua-Jun Zhao, Yi-Fei Hu, Qiu-Ju Han, Jian Zhang
Summary: This review provides a detailed explanation of the immunological and biological characteristics of chronic hepatitis B virus infection, as well as the escape mechanisms of the virus. It also discusses novel immune-based therapies for treating hepatitis B virus.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pediatrics
Eric W. Hall, Lakshmi Panagiotakopoulos, Carolyn Wester, Noele Nelson, Amy L. Sandul
Summary: This study determines the optimal testing strategy for identifying children with perinatally acquired HCV infection, showing that testing infants at 2-6 months with a single HCV RNA test reduces costs and improves health outcomes.
JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Yanqin Du, Olympia E. Anastasiou, Benedikt Strunz, Janina Scheuten, Birgit Bremer, Anke Kraft, Karolina Kleinsimglinhaus, Daniel Todt, Ruth Broering, Matthias Hardtke-Wolenski, Jun Wu, Dongliang Yang, Ulf Dittmer, Mengji Lu, Markus Cornberg, Niklas K. Bjorkstrom, Tanvi Khera, Heiner Wedemeyer
Summary: The study assessed the effects of HBsAg quantities on NK cell functionality in CHB patients, finding a reshaping of the NK cell pool towards more CD56(bright) NK cells during infection. Patients with low HBsAg levels displayed an activated NK cell phenotype with defective functional responses.
LIVER INTERNATIONAL
(2021)
Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Article
Gastroenterology & Hepatology
Xiaoli Wu, Zhenzhen Yao, Xin Lai, Yingping Gu, Songxu Peng
Summary: This study investigated the associations between age at treatment initiation and treatment outcomes in children with chronic hepatitis B (CHB). The study found that younger age at treatment initiation was associated with higher rates of HBsAg loss and HBeAg clearance.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Chao Mo, Jie Zhao, Jingyan Liang, Huiling Wang, Yu Chen, Guodong Huang
Summary: Exosomes play a crucial role in intercellular communication, and the interaction between exosomes and traditional Chinese medicine (TCM) has beneficial effects on various diseases. TCM formulas and compounds can modulate exosomes to inhibit cell proliferation, reduce inflammation, and attenuate fibrosis. Additionally, exosomes serve as a natural delivery system for TCM compounds, and they may also be potential biomarkers for TCM syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Peng Huang, Jing-Jing Wu, Jin-Wei Zhang, Yu-Qing Hou, Ping Zhu, Rong Yin, Rong-Bin Yu, Yun Zhang, Ming Yue, Wei Hou
Summary: This study investigates the connection between retinoic acid-inducible gene I-like receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. It found that DHX58 rs2074158-G allele and IFIH1 rs10930046-C allele are associated with chronic hepatitis C (CHC). The risk of CHC increases with the number of unfavorable genotypes carried by the infected person. IFIH1 rs10930046, DHX58 rs2074158, age, ALT, and AST levels are independent predictors of CHC.
Article
Multidisciplinary Sciences
Youkyung H. Choi, Hyun Woong Lee, Michael A. Purdy
Summary: B1 cell-derived natural antibodies are associated with the treatment outcomes of chronic hepatitis B patients receiving entecavir treatment, and high levels of natural antibodies are significantly related to HBeAg-positivity and HBeAg seroconverters.
SCIENTIFIC REPORTS
(2022)
Review
Infectious Diseases
Hua Zhong, Lei Han, Ren-Yi Lu, Yan Wang
Summary: Fungal infections pose a growing public health challenge with limited treatment options. To overcome this, the development of new antifungal drugs from natural products and synthetic biology strategies is promising. Traditional Chinese medicine (TCM) holds a vast library of biologically active molecules with antifungal and immunomodulatory properties. Combining antifungal drugs with immunomodulatory agents may yield better results. The review focuses on the latest research progress of TCM components with antifungal and immunomodulatory effects, aiming to inspire the design of novel antifungal compounds and treatment strategies.
Article
Economics
Piyameth Dilokthornsakul, Ratree Sawangjit, Pisit Tangkijvanich, Maneerat Chayanupatkul, Tawesak Tanwandee, Wattana Sukeepaisarnjaroen, Pajaree Sriuttha, Unchalee Permsuwan
Summary: This study evaluated the cost-effectiveness of nucleos(t)ide analogues (NAs) for chronic hepatitis B (CHB) treatment in Thailand. The results showed that TAF, TDF, LAM/TAF, and LAM/TDF were dominant options, while ETV/TAF or ETV/TDF were cost-effective options.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2022)
Review
Medicine, General & Internal
Wen-Juei Jeng, George Papatheodoridis, Anna S. F. Lok
Summary: Hepatitis B virus (HBV) infection is a significant global public health problem, with a large number of chronic infections and deaths reported every year. Diagnosis of HBV infection requires serological testing for specific antibodies. Treatment mainly focuses on preventing liver disease progression and development of complications. Efforts are being made to develop new therapies that aim for a functional cure, while prevention strategies include universal vaccination and improved screening and diagnosis. Achieving the goal of eliminating HBV infection by 2030 requires a comprehensive approach.
Article
Multidisciplinary Sciences
Satoru Joshita, Masao Ota, Hiroyuki Kobayashi, Shun-ichi Wakabayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Eiji Tanaka, Takeji Umemura
Summary: This study revealed significant associations of KIR/HLA with HCC development (KIR2DS3) and freedom from NUC therapy (KIR3DL1/HLA-Bw4) in HBV patients, although larger case studies are needed for statistical purposes.
SCIENTIFIC REPORTS
(2021)