Journal
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
Volume 14, Issue 4, Pages 281-285Publisher
SPRINGER
DOI: 10.1007/s11655-008-0281-3
Keywords
Shengmai injection; coronary heart disease; diabetes mellitus; vascular endothelial function; heart function
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Objective: To study the effect of Shengmai injection (SMI) on vascular endothelial and heart functions in coronary heart disease patients complicated with diabetes mellitus (CHD-DM). Methods: One hundred and twenty patients with CHD-DM, their diagnosis confirmed by coronary arteriography, were equally randomized into a control group treated with conventional treatment and a treated group treated with conventional treatment plus SMI. The changes in blood levels of nitric oxide (NO), endothelin-1 (ET-1) and angiotensin II (Ang II), as well as endothelium-dependent vascular dilating function and heart function in the patients were observed before treatment and after the 3-week treatment. Results: After being treated with SMI for 3 weeks, in the treated group, blood level of NO was raised significantly from 69.8 +/- 33.1 mu mol/L to 120.1 +/- 50.8 mu mol/L, and ET-1 was lowered from 70.1 +/- 32.1 ng/L to 46.2 +/- 21.3 ng/L, respectively (P<0.01); that of Ang II was lowered from 81.3 +/- 24.3 ng/L to 50.2 +/- 27.3 ng/L (P<0.01); brachial arterial post-congestion blood flow increasing rate was raised from 389.4 +/- 26.3% to 459.3 +/- 27.8% (P<0.01); and the improvement in heart function as seen through the ejection fraction (EF) was increased from 44 +/- 5% to 68 +/- 6% (P<0.01), all the changes being more significant than those in the control group (all P<0.01). Conclusion: SMI can improve not only the endothelial function in CHD-DM patients, but also heart contraction significantly.
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