Article
Biochemistry & Molecular Biology
Yule Chen, Hanjiang Wang, Ke Wang, Guodong Zhu, Zhishang Yang, Min Wang, Wenbin Song
Summary: By comparing the abundance of serum metabolites between APA and EHT patients, as well as pre- and postoperative APA patients, this study reveals that APA might participate in cardiovascular and metabolic diseases by regulating serum metabolites.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Peripheral Vascular Disease
Vin-Cent Wu, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Bertrand Chin-Ming Tan, Yen-Hung Lin, Tai-Shuan Lai, Yung-Ming Chen, Jeff S. Chueh
Summary: In patients with unilateral primary aldosteronism, the coexistence of aldosterone-producing micronodules/nodules may have a negative impact on clinical success, as these patients are more likely to have persistent hypertension post-adrenalectomy. This may be explained by the attenuated HTR2B-mediated PLC/IP3/Ca2(+) pathway in Group A adenomas, as revealed by pathway enrichment analysis based on RNA-seq data.
Article
Immunology
Che-Mai Chang, Kang-Yung Peng, Chieh-Kai Chan, Yu-Feng Lin, Hung-Wei Liao, Jan-Gowth Chang, Mai-Szu Wu, Vin-Cent Wu, Wei-Chiao Chang
Summary: This study demonstrates that patients with aldosterone-producing adenoma (APA) have reduced T-cell immune repertoire diversity and exhibit differences compared to patients with hypertension. The study also reveals a stronger correlation between T-cell receptor (TCR) clonotype generation probabilities and frequencies in the APA group. Clinical features are positively associated with the strength of correlation between TCR clonotype generation and abundance in the APA group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Huiping Wang, Fen Wang, Yushi Zhang, Jin Wen, Dexin Dong, Xiaoyan Chang, Hao Sun, Xiaosen Ma, Yunying Cui, Shi Chen, Lin Lu, Weidong Ren, Anli Tong, Yuxiu Li
Summary: This study evaluated the surgical outcomes of aldosterone-producing adenoma (APA) patients based on functional pathological diagnosis, showing a high rate of clinical success postoperatively. Pathological analysis identified mainly APA and aldosterone-producing nodule (APN), with gender, duration of hypertension, and highest SBP as independent predictors for the postoperative cure of APA.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Celso E. Gomez-Sanchez, Desmare van Rooyen, William E. Rainey, Kazutaka Nanba, Amy R. Blinder, Radhakrishna Baliga
Summary: Aldosterone-producing adenoma is a rare cause of hypertension in children. This study describes a novel somatic KCNJ5 p.I157S mutation in an aldosterone-producing adenoma from a 16-year-old black female. Prompt diagnosis and early identification of gene mutations can lead to appropriate therapy and reduce cardiovascular sequelae.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Jui-Hsiang Lin, Kang-Yung Peng, Yu-Ping Kuo, Hsuan Liu, Chin-Ming Bertrand Tan, Yuh-Feng Lin, Hui-Wen Chiu, Yen-Hung Lin, Yung-Ming Chen, Jeff S. Chueh, Vin-Cent Wu
Summary: This study found that one-third of patients with unilateral primary aldosteronism (uPA) also had autonomous cortisol secretion (ACS). The presence of multiple aldosterone-producing nodules/micronodules (mAPN/mAPM) in these patients was associated with larger tumor sizes and the interaction between them. Transcriptome analysis and bioinformatics revealed the significance of the HSD3B7/CYP11B1 signaling pathway in uPA adenomas with surrounding mAPN/mAPM. Furthermore, patients with concomitant mAPN/mAPM had lower rates of biochemical success after surgery.
ENDOCRINE-RELATED CANCER
(2022)
Article
Endocrinology & Metabolism
Fabio Bioletto, Chiara Lopez, Martina Bollati, Stefano Arata, Matteo Procopio, Federico Ponzetto, Guglielmo Beccuti, Giulio Mengozzi, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: This study investigated the feasibility of using aldosterone-to-renin ratio (ARR) as a diagnostic criteria for primary aldosteronism (PA) in patients with resistant hypertension (RH). The results showed that in normokalemic patients, ARR had a lower diagnostic accuracy and may not accurately differentiate between PA and essential RH. However, in patients with hypokalemia, ARR had a higher diagnostic accuracy and may serve as a diagnostic criterion for PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jun Yang, Stella May Gwini, Lawrence J. Beilin, Markus Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori
Summary: Oral contraception can increase the aldosterone to renin ratio, leading to false positive results in the screening for primary aldosteronism. Until more reliable criteria for primary aldosteronism screening in oral contraception users are established, alternative contraception methods should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Paolo Mulatero, Chiara Bertello, Franco Veglio, Silvia Monticone
Summary: Primary aldosteronism is an overlooked condition with significant mortality and morbidity. The difficulty of screening patients on antihypertensive therapy has resulted in low testing rates. However, interference with medication may not always be necessary for accurate screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Review
Endocrinology & Metabolism
Koshiro Nishimoto, Tadashi Ogishima, Yuki Sugiura, Makoto Suematsu, Kuniaki Mukai
Summary: The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. CYP11B2 and CYP11B1 play crucial roles in their synthesis. This study successfully purified and identified CYP11B2 as aldosterone synthase, allowing for visualization of functional histology and discovering new aldosterone-producing lesions.
Article
Medicine, General & Internal
Tomasz Pizon, Marek Rajzer, Wiktoria Wojciechowska, Tomasz Drozdz, Dorota Drozdz, Marta Rojek, Krystian Gruszka, Danuta Czarnecka
Summary: The study aimed to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO), and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH). High PRA patients had higher ALDO levels, and those with simultaneously high PRA and ARR values showed more severe arterial stiffness and renal impairment. Assessment of the influence of the renin-angiotensin-aldosterone system on AOD should consider the relationship between renin and aldosterone.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Peripheral Vascular Disease
Lebo F. Gafane-Matemane, Ruan Kruger, Wayne Smith, Catharina M. C. Mels, Johannes M. Van Rooyen, Gontse G. Mokwatsi, Aletta S. Uys, Sanette J. Brits, Aletta E. Schutte
Summary: This study showed differences in the renin-angiotensin-aldosterone system, electrolytes, blood pressure, and total peripheral resistance between healthy young Black and White adults. RAAS concentrations were found to be half in Black adults compared to White adults, but the increase in blood pressure over time was faster in Black individuals. RAAS was similar in Black and White adults only in scenarios of low Na+/K+ values, indicating a potential essential role of potassium.
Article
Biochemistry & Molecular Biology
Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasano
Summary: This study analyzed the histological characteristics, cholesterol metabolism, and differences related to gene mutations in aldosterone-producing adenomas (APAs). The results showed that mutated KCNJ5 genes in APAs were associated with higher plasma aldosterone concentration and more lipid droplets in compact tumor cells compared to non-mutated APAs. Additionally, cholesterol uptake and synthesis were found to be different between clear and compact tumor cells, with mutated KCNJ5 APAs showing enhanced cholesterol ester uptake and de novo synthesis.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Review
Cardiac & Cardiovascular Systems
Andrea Cignarella, Gian Paolo Fadini, Chiara Bolego, Lucia Trevisi, Carlotta Boscaro, Viola Sanga, Teresa Maria Seccia, Antonio Rosato, Gian Paolo Rossi, Matthias Barton
Summary: This review discusses the challenges clinicians face in angiogenesis inhibitor therapy, including the need to consider sex differences in clinical efficacy and safety, and proposes future research directions.
CARDIOVASCULAR RESEARCH
(2022)
Article
Peripheral Vascular Disease
Gian Paolo Rossi, Filippo Crimi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Vin Cent Wu, Zuzana Kratka, Giulio Barbiero, Michele Battistel, Teresa Maria Seccia
Summary: Imaging can accurately identify unilateral primary aldosteronism in most young patients, especially those with a unilateral adrenal nodule and hypokalemia, but adrenal vein sampling is still necessary for patients without nodules/bilateral nodules or hypokalemia.
Letter
Endocrinology & Metabolism
Gian Paolo Rossi, Giacomo Rossitto
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Letter
Peripheral Vascular Disease
Donatella Schiavone, Maurizio Iacobone, Gian Paolo Rossi
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Review
Endocrinology & Metabolism
Livia Lenzini, Brasilina Caroccia, Teresa Maria Seccia, Gian Paolo Rossi
Summary: Understanding the regulation of adrenal function and the interactions between adrenal cortex and medulla is crucial for studying the mechanisms of various diseases. The modulation of adrenal hormone biosynthesis is a complex process involving multiple factors working together. Tight vascular and neural connections between the adrenal cortex and medulla play a role in physiological autocrine/paracrine interactions involving several peptides.
Article
Biochemistry & Molecular Biology
Ilaria Caputo, Brasilina Caroccia, Ilaria Frasson, Elena Poggio, Stefania Zamberlan, Margherita Morpurgo, Teresa M. Seccia, Tito Cali, Marisa Brini, Sara N. Richter, Gian Paolo Rossi
Summary: Blockers of the renin-angiotensin system (RAS) can increase the expression of ACE2, the cellular receptor of SARS-CoV-2, and thus increase the risk of COVID-19. This study found that angiotensin II (Ang II) significantly increased the levels of ACE2 expression by acting on the angiotensin type 1 receptor, resulting in enhanced viral entry into cells. However, the blockade of ACE-1-mediated Ang II formation and ACE2-mediated Ang II conversion did not have any effect. Therefore, increased production of Ang II in patients with an activated RAS may lead to a greater spread of COVID-19 infection in lung cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Peripheral Vascular Disease
Viola Sanga, Giacomo Rossitto, Teresa Maria Seccia, Gian Paolo Rossi
Summary: This study aims to diagnose primary aldosteronism in pregnancy (PAP) and provide management suggestions based on the evidence obtained. A nomogram was developed to identify PAP cases based on the changes in aldosterone and renin. PAP cases were classified into four groups with different management and outcomes. Adrenalectomy did not improve maternal and fetal outcomes compared to medical treatment alone. Early detection and surgical treatment of unilateral PAP resulted in better outcomes for maternal hypertension and mother and baby outcomes.
Article
Medicine, Research & Experimental
Jun Yu Chen, Khai Syuen Chew, Sheon Mary, Philipp Boder, Domenico Bagordo, Gian Paolo Rossi, Rhian M. Touyz, Christian Delles, Giacomo Rossitto
Summary: Increasing evidence suggests excess skin Na+ accumulation is associated with hypertension. This study investigated the relationship between sweat and trans-epidermal water loss (TEWL) measures with skin Na+ content and clinical characteristics in hypertensive patients. The results showed that sweat Na+ concentration was inversely correlated with sweat K+ concentration and higher in patients on ACEIs/ARBs. There was a positive association between sweat Na+ concentration and skin Na+ content, independent of other factors.
Article
Endocrinology & Metabolism
Rui Zhu, Tungalagtamir Shagjaa, Giacomo Rossitto, Brasilina Caroccia, Teresa Maria Seccia, Dario Gregori, Gian Paolo Rossi
Summary: This study evaluated the diagnostic accuracy of exclusion tests for primary aldosteronism compared to the aldosterone to renin ratio. The results showed that exclusion tests did not provide a diagnostic gain over the aldosterone to renin ratio. Therefore, the systematic use of these exclusion tests in clinical practice is not justified by available evidence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Peripheral Vascular Disease
M. Piazza, N. M. J. Hanssen, J. L. J. M. Scheijen, M. Vd Waarenburg, B. Caroccia, T. M. Seccia, C. D. A. Stehouwer, G. P. Rossi, C. G. Schalkwijk
Summary: This study investigated the association between serum AT1AA levels and serum MGO and AGE levels in APA patients, and found no significant correlation between these markers. Furthermore, no significant changes were observed in these markers after adrenalectomy in APA patients.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Gian Paolo Rossi, Domenico Bagordo, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Magill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Chin-Chen Chang, Vin-Cent Wu, Zuzana Kratka, Michele Battistel, Giacomo Rossitto, Teresa Maria Seccia
Summary: This study investigates whether selectively unilateral adrenal vein sampling can identify the responsible adrenal gland.
Article
Biochemistry & Molecular Biology
Brasilina Caroccia, Teresa Maria Seccia, Giorgia Pallafacchina, Maria Piazza, Ilaria Caputo, Stefania Zamberlan, Rosario Rizzuto, Gian Paolo Rossi
Summary: In a Northern Italy population with a high prevalence of arterial hypertension and cardiovascular disease, the contamination of drinking water with perfluoroalkyl substances (PFAS) significantly increased the levels of pentadecafluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in the plasma. It was investigated whether PFAS enhance the biosynthesis of aldosterone, a known pressor hormone. The study found that PFAS significantly increased the expression of the aldosterone synthase gene, doubled aldosterone secretion, and caused an increase in cellular and mitochondrial production of reactive oxygen species (ROS) in human adrenocortical carcinoma cells. These findings suggest that PFAS may contribute to the development of arterial hypertension through increased aldosterone production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Viola Sanga, Eleonora Bertoli, Filippo Crimi, Giulio Barbiero, Michele Battistel, Teresa Maria Seccia, Gian Paolo Rossi
Summary: This study reports on a series of consecutive patients with recurrent hospital admissions for pulmonary edema and impaired renal function, who were found to have atherosclerotic bilateral renal artery stenosis, a condition known as Pickering syndrome. The study suggests that a simplified diagnostic strategy can help identify this syndrome, leading to successful revascularization and improved patient outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Teresa Maria Seccia, Tungalagtamir Shagjaa, Margherita Morpurgo, Brasilina Caroccia, Viola Sanga, Sonia Faoro, Francesca Venturini, Girolama Iadicicco, Sara Lococo, Maria Mazzitelli, Filippo Farnia, Paola Fioretto, Yusuke Kobayashi, Dario Gregori, Gian Paolo Rossi
Summary: Despite WHO no longer considering SARS-CoV-2 a public health emergency, the development of effective treatments for COVID-19 remains crucial. The protease inhibitor nafamostat has shown potential for treating COVID-19 infections by inhibiting virus entry and preventing complications. The RACONA study demonstrated that nafamostat has a good safety profile and could be beneficial for COVID-19 hospitalized patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Surgery
Donatella Schiavone, Mattia Ballo, Marco Filardo, Silvia Dughiero, Francesca Torresan, Gian Paolo Rossi, Maurizio Iacobone
Summary: Subtotal adrenalectomy leads to less post-surgical primary adrenal insufficiency, but has a higher postoperative recurrence rate.