Journal
CHINESE JOURNAL OF CHEMICAL ENGINEERING
Volume 18, Issue 5, Pages 750-754Publisher
CHEMICAL INDUSTRY PRESS CO LTD
DOI: 10.1016/S1004-9541(09)60124-5
Keywords
Tripterygium wilfordii Hook F; triptolide; high-speed counter-current chromatography
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Funding
- National Natural Science Foundation of China [20576113]
- Zhejiang Provincial Natural Science Foundation of China [R4090358]
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Triptolide is an important active component of Tripterygium wilfordii Hook F (TWHF) and possesses anti-inflammatory, immunosuppressive, male anti-fertility, and anticancer properties. A new method combining different techniques, including solid-liquid extraction, liquid-liquid partition, column chromatography and high-speed counter-current chromatography (HSCCC) but avoiding the use of chloroform, was developed for the isolation and purification of triptolide from the leaves of TWHF. 48 mg of triptolide at 96.5% purity was obtained from 1 kg of air-dried leaves of TWHF.
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