Article
Chemistry, Organic
Isabel Valencia, Patricia Garcia-Garcia, David Sucunza, Francisco Mendicuti, Juan J. Vaquero
Summary: Previously unknown BN-PAHs 1,10a-dihydro-1-aza-10a-boraphenanthrene and 6a,7-dihydro-7-aza-6a-boratetraphene have been efficiently synthesized and exhibit high fluorescence quantum yields. Bromination of these compounds proceeds with complete regioselectivity, resulting in the formation of different substituted derivatives via cross-coupling reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Immunology
Anthony L. Komaroff, Roberta Rizzo, Jeffrey L. Ecker
Summary: HHV-6A and HHV-6B are ancient human viruses that can cause lifelong infection and are associated with various diseases. These viruses may have an impact on infertility, preeclampsia, and other reproductive diseases, but further research is needed to fully understand their role.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wangko Lundstroem, Rasmus Gustafsson
Summary: The role of HHV-6A in multiple sclerosis is controversial, but recent studies suggest that HHV-6A may play a significant role, especially in the early stages of the disease. MS patients show an increased immune response against HHV-6A compared to HHV-6B. Furthermore, HHV-6A infection interacts with other factors that may modulate MS susceptibility and progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Angela Y. Zhu, Nandita Mitra, David J. Margolis
Summary: This study examines the association between keratin 6 variants and severity of atopic dermatitis over time. It identifies groups of variants that have similar effects on skin repair, providing insights for the treatment of atopic dermatitis.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Farooq L. J. Almohaisen, Somayyeh Heidary, Mohamed L. Sobah, Alister C. Ward, Clifford Liongue
Summary: The study identified and characterized zebrafish BCL6A and its role in immune cell development and function, with a focus on early macrophages. The findings suggest a strong conservation of BCL6A across evolution and highlight its importance in macrophage biology.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yulia S. Panova, Alexandra V. Khristolyubova, Vyacheslav V. Sushev, Natalia V. Zolotareva, Evgeny V. Baranov, Georgy K. Fukin, Alexander N. Kornev
Summary: This study reveals that the interaction of 1,4-dichloro-3a,6a-diaza-1,4-diphosphapentalenes with metallic Na or Li or the naphthalene-Na anion-radical salt in THF proceeds through several successive stages, ultimately resulting in a stable aromatic 1,2,3-azadiphospholide ion.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Virology
Salma Aktar, Jun Arii, Thi Thu Huong Nguyen, Jing Rin Huang, Mitsuhiro Nishimura, Yasuko Mori
Summary: This study analyzed the role of CREB family of transcription factors in HHV-6A replication. The results showed that HHV-6A infection enhances phosphorylation of CREB family members CREB1 and ATF1. Knockout of CREB1 or ATF1 enhances viral gene expression and viral replication. Additionally, RNA-seq analysis revealed that sensors of the innate immune system are downregulated in ATF1-KO cells and mRNA of IFN-beta and IFN-regulated genes are reduced in HHV-6A-infected cells. Treatment of ATF1-KO cells with IFN-beta significantly reduces viral yields.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Valentina A. Karnoukhova, Vladimir V. Baranov, Anna V. Vologzhanina, Angelina N. Kravchenko, Ivan V. Fedyanin
Summary: The self-organization of 1,6-dimethyl(diethyl)-3a,6a-diphenylglycolurils in crystals was studied, revealing the impact of solvents on H-bonding structures and crystal morphology. Solvent molecules typically act as terminal groups in H-bonded chains. This organization results in materials with superhydrophobic surfaces due to the repulsion of bulk water.
Article
Biochemistry & Molecular Biology
Qian Lv, Liqun Li, Ying Meng, Huimin Sun, Liuping Chen, Bingxin Wang, Xuejun Li
Summary: The study revealed that TaGW2-6A interacts with TaAGPS and degrades TaAGPS through the 26S proteasome pathway, influencing seed size. This mechanism provides new insights into the formation of wheat grain weight.
Article
Geochemistry & Geophysics
Oliver Montenbruck, Stefan Hackel, Martin Wermuth, Franz Zangerl
Summary: The Sentinel-6 (or Jason-CS) altimetry mission extends previous missions for ocean surface topography monitoring, requiring highly accurate knowledge of orbital position. The Sentinel-6A spacecraft uses a dual-constellation GNSS receiver for precise orbit determination and achieves 1 cm consistency in solutions. Galileo measurements exhibit smaller errors than GPS, but the POD benefits from the increased number of satellites in the combined solution, ultimately meeting mission needs for RMS height errors of less than 1.5 cm.
JOURNAL OF GEODESY
(2021)
Article
Immunology
Michael Mariani, Cosima Zimmerman, Princess Rodriguez, Ellie Hasenohr, Giulia Aimola, Diana Lea Gerrard, Alyssa Richman, Andrea Dest, Louis Flamand, Benedikt Kaufer, Seth Frietze
Summary: Human herpesvirus HHV-6A/B can integrate their genomes into human chromosomes, leading to individuals harboring the viral genome in every cell. Research shows that HHV-6A becomes transcriptionally silent in infected cells and interacts with quiescent chromatin states. Most virus chromatin interactions occur towards the distal ends of specific human chromosomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Giulia Aimola, Darren J. Wight, Louis Flamand, Benedikt B. Kaufer
Summary: Human herpesviruses 6A and 6B can integrate their genomes into the telomeres of cells, including germ cells, leading to individuals who carry the integrated virus in every cell and can pass it on to their offspring. In this study, a CRISPR/Cas9 system was developed to remove HHV-6A from host telomeres. The virus genome was efficiently excised and lost in most cells, without reactivation. This approach enables the efficient removal of the integrated virus genome.
MICROBIOLOGY SPECTRUM
(2023)
Review
Microbiology
Anthony L. Komaroff, Philip E. Pellett, Steven Jacobson
Summary: This review examines the evidence that Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) may trigger neurological diseases in humans, including encephalitis in immunocompromised patients and febrile seizures in infants and children. It also discusses the criteria for linking infectious agents to neurologic diseases and evaluates the extent to which these criteria have been met for HHV-6A/B and various neurological conditions.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Daisuke Tsuji, Atsushi Nakayama, Riko Yamamoto, Shuji Nagano, Takashi Taniguchi, Ryota Sato, Sangita Karanjit, Naoki Muguruma, Tetsuji Takayama, Kohji Itoh, Kosuke Namba
Summary: This study investigated the photo-induced cytotoxicities of various TAP derivatives. Among the derivatives, 2-p-nitrophenyl-TAP showed significant cytotoxicity to HeLa cells under UV irradiation but no cytotoxicity without UV. In addition, the photo-induced cytotoxicity of 2-p-nitirophenyl-TAP was found to be cancer cell selective and effective against HeLa cells and HCT 116 cells. Therefore, small molecule dyes with selective and efficient photo-induced cytotoxicity have been developed.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Immunology
Abigael Eva Chaouat, Barbara Seliger, Ofer Mandelboim, Dominik Schmiedel
Summary: The coevolution of human immune system and herpesviruses led to the emergence of cellular danger molecules and viral countermeasures. HHV-6A encodes immunoevasins U20 and U21 to suppress NKG2D ligands ULBP1 and ULBP3, impairing immune recognition. The study highlights the evolutionary conserved immune escape mechanisms of HHV-6A and HHV-6B towards NKG2D ligands.
FRONTIERS IN IMMUNOLOGY
(2021)
