Relationship between expression of beta-catenin and VEGFs (VEGFA, VEGF-C), VEGF receptors-2 (VEGFR-2) in medulloblastoma

Objective: To investigate the expression of beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGF receptor-2 (VEGFR-2) protein in medulloblastoma. Methods: Immunohistochemical staining with SP method was conducted to determine the expression of beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues. Results: The expression rate of beta-catenin, and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. A significant positive correlation was found between beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 protein in medulloblastoma. Conclusion: There was a correlation between beta-catenin and VEGFs (VEGF-A, VEGF-C) and VEGFR-2 in medulloblastoma, which may play a role in the pathogenesis and development of medulloblastoma.