Journal
CHINESE CHEMICAL LETTERS
Volume 30, Issue 2, Pages 403-405Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.08.016
Keywords
Multifunctional integrated microfluidic biochip; Cirsium setosum (Wild.); Efficacy-toxicity of medicines; Compatibility of medicines; Simultaneously online screening
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A multifunctional integrated microfluidic biochip device was engineered to estimate the activity-toxicity and composition principle of medicine in a cell model in vitro. This biochip could be used for disease cells and healthy cells in two modules of Yin-Yang on the same chip for detecting the medicine efficacy-toxicity simultaneously, as well as adjust different gradient ratios of concentration through the Christmas tree structure in both Yin-Yang modules autonomously for detecting the best compatibility of medicine in maximum efficacy and minimal toxicity. In the applicability experiment, the best concentration of three chemical compounds including dinatin, diosmetin and cisplatin, were detected using the biochip and traditional 96-cell plate. Biochip assays showed perfect positive correlation compared with the results of traditional 96-cell plate, in addition presented advantages as less detection time and much lower price than the traditional 96-cell plate, which indicated the biochip is both convenient and feasible. Thus, the novel microfluidic chip-based multifunctional integrated system congregated the virtues of high throughput, rapid, sensitive, specific, cost-effective, and similar to the physical environment of the human body, which was especially suitable for the medicine efficacy-toxicity and compatibility evaluation. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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