Journal
CHINESE CHEMICAL LETTERS
Volume 25, Issue 5, Pages 805-808Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2014.03.024
Keywords
Selaginella; Selaginella involven Spring; Abietane diterpenoid; Lignans; PC-12 cell
Categories
Funding
- National Natural Science Foundation [31370370]
- Doctoral Program Foundation of Institutions of Higher Education of China [20100162110057]
- Chinese Medicine Research Program of Hunan Province [2009059, 2010004]
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Two new compounds named as 3 beta,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8'S)-4,4',8-trihydroxyl-3,3'-dimethoxyl-9'-lignanolide (2) and a new natural product 4,4'-dihydroxyl-3,3',5,5'-dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2D NMR and MS methods. Additionally, these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation. (C) 2014 Gui-Shan Tan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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