Article
Chemistry, Multidisciplinary
Jinju Cai, Jingru Shi, Chen Chen, Mengping He, Zhiqiang Wang, Yuan Liu
Summary: SFAs substantially enhance the antibacterial activity against mcr-positive bacteria, inhibit biofilm formation and eliminate matured biofilms, prevent the spread of mobile colistin resistance, and exhibit excellent therapeutic effect in animal infection models.
Article
Environmental Sciences
Niamh Cahill, Brigid Hooban, Kelly Fitzhenry, Aoife Joyce, Louise O'Connor, Georgios Miliotis, Francesca McDonagh, Liam Burke, Alexandra Chueiri, Maeve Louise Farrell, James E. Bray, Niall Delappe, Wendy Brennan, Deirdre Prendergast, Montserrat Gutierrez, Catherine Burgess, Martin Cormican, Dearbhaile Morris
Summary: The emergence and dissemination of mobile colistin resistance (mcr) genes poses a significant threat to public health, as colistin is one of the last line treatment options for multi-drug resistant infections. This study identified several bacteria carrying mcr genes, mainly in water sources and wastewater, along with other multi-drug resistance genes. These findings highlight the need for further research to understand the role of the environment in the persistence and dissemination of antimicrobial resistance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Tukaram S. Choudhare, Devendra S. Wagare, Sagar E. Shirsath, Prashant D. Netankar
Summary: By utilizing formic acid as a medium, one-pot condensation of pyrazole-4-aldehydes and hydroxylamine hydrochloride, followed by dehydration with a catalytic amount of orthophosphoric acid, leads to the formation of novel pyrazole-4-carbonitrile. This metal-free and cost-effective method yields excellent results and provides a versatile precursor for the synthesis of various valuable compounds.
JOURNAL OF CHEMICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Panasa Mahesh, Parameswari Akshinthala, Naresh Kumar Katari, Lavleen Kumar Gupta, Dikshita Panwar, Manoj Kumar Sharma, Sreekantha Babu Jonnalagadda, Rambabu Gundla
Summary: In this study, two new series of 3,5-dimethyl-1H-pyrazole-4-sulfonamide and 1,3,5-trimethyl-1H-pyrazole-4-sulfonamide derivatives were designed and synthesized. These derivatives were characterized by various analytical techniques and their biological evaluation data were presented, paving the way for the development of new pyrazole-4-sulfonamide derivatives.
Article
Multidisciplinary Sciences
Qi Zhang, Runming Wang, Chunjiao Liu, Minji Wang, Mohamad Koohi-Moghadam, Pak-Leung Ho, Hongyan Li, Haibo Wang, Robert Bonomo, Hongzhe Sun
Summary: The study found that silver (Ag+), including silver nanoparticles, can restore the efficacy of colistin against mcr-positive bacteria by inhibiting the activity of the MCR-1 enzyme and slowing down the development of resistance. The combined use of Ag+ and colistin can relieve dermonecrotic lesions and reduce the bacterial load of mice infected with mcr-1-carrying pathogens. This suggests the potential of Ag+ as a broad-spectrum inhibitor for treating mcr-positive bacterial infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Michael Timmermans, Pierre Wattiau, Olivier Denis, Cecile Boland
Summary: This study identified a reservoir of mobile colistin resistance genes (mcr-1 to -5) in commensal Escherichia coli isolated from healthy pigs, cattle and poultry in Belgium over at least 5 years (2012-2016), highlighting the ongoing presence of colistin resistance genes in these animal populations.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Chemistry, Physical
Mounir Cherfi, Tarik Harit, Meryem Idrissi Yahyaoui, Abdelkhalek Riahi, Abdeslam Asehraou, Fouad Malek
Summary: The design of two new macrocycles containing pyrazole-tetrazole subunits and a lateral arm is presented in this study. The synthesis and characterization of these macrocycles and intermediate compounds were conducted using various spectroscopic and analytical techniques. Two synthetic routes were evaluated, and the second route was found to be more successful in yielding the desired macrocycles. The antimicrobial activity of these macrocycles was evaluated, and in-silico docking calculations provided insights into their interaction with the target protein.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Multidisciplinary
Karim Chkirate, Khalid Karrouchi, Hind Chakchak, Joel T. Mague, Smaail Radi, N. N. Adarsh, Weiyang Li, Ahmed Talbaoui, El Mokhtar Essassi, Yann Garcia
Summary: In this study, three new mononuclear coordination complexes were successfully synthesized and characterized using crystal structures and spectroscopic analysis. The supramolecular architectures of these complexes were investigated through crystal packing analysis, emphasizing the hydrogen bonding interactions. The in vitro evaluation demonstrated the excellent antibacterial activity of these complexes against various bacterial strains.
Article
Chemistry, Physical
C. Sivakumar, V. Balachandran, B. Narayana, Vinutha V. Salian, B. Revathi, N. Shanmugapriya, K. Vanasundari
Summary: The compound CCPPE was studied for its structure, charge exchange, vibrational spectra, and antimicrobial activity performances.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Agriculture, Dairy & Animal Science
Antonietta Di Francesco, Daniela Salvatore, Sonia Sakhria, Fabrizio Bertelloni, Elena Catelli, Salma Ben Yahia, Aida Tlatli
Summary: A survey conducted in Tunisia found that 41.5% of broiler chickens tested positive for the mcr-1 gene, which confers resistance to colistin. This highlights the urgent need for cautious use of colistin in the veterinary field.
Article
Biochemistry & Molecular Biology
Cheng Hong Yap, Abdul Qaiyum Ramle, See Khai Lim, Avinash Rames, Sun Tee Tay, Sek Peng Chin, Lik Voon Kiew, Edward R. T. Tiekink, Chin Fei Chee
Summary: Staphylococcus aureus is an adaptable pathogen that can form biofilms and generate persister cells. In this study, a new compound was synthesized and found to have promising antibiofilm activities against S. aureus.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Microbiology
Christian Valdez, Catia Costa, Marco Simoes, Carla C. C. R. de Carvalho, Teresa Baptista, Maria J. Campos
Summary: The increase in antimicrobial resistant strains poses an emerging threat to public health. Clams, as marine invertebrates, serve as a natural reservoir for specific microbial communities, including antimicrobial resistant Vibrio and coliforms. Phenotypic resistance to colistin was found in three Vibrio strains, which also carried the mcr-1 gene. The resistance was found to be chromosomally mediated and the isolates were genetically distinct from known Vibrio species.
Article
Food Science & Technology
Ihab Habib, Mohammed Elbediwi, Akela Ghazawi, Mohamed-Yousif Ibrahim Mohamed, Glindya Bhagya Lakshmi, Mushtaq Khan
Summary: Plasmid-borne colistin resistance is a complex public health concern worldwide. This study reports the presence of mcr-1.1-mediated colistin resistance in multidrug-resistant S. Minnesota isolates from retail chicken meat samples in the UAE. The isolates exhibited different patterns of β-lactamase resistance genes and carried an IncX4 plasmid. Further investigation is needed at the national level.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Mohd Asyraf Shamsuddin, Amatul Hamizah Ali, Nur Hanis Zakaria, Mohd Fazli Mohammat, Ahmad Sazali Hamzah, Zurina Shaameri, Kok Wai Lam, Wun Fui Mark-Lee, Hani Kartini Agustar, Mohd Ridzuan Mohd Abd Razak, Jalifah Latip, Nurul Izzaty Hassan
Summary: The study synthesized a new series of hybrids, among which 4b demonstrated strong antiplasmodial activity against both 3D7 and K1 strains with low cytotoxic effect. It displayed high selectivity index and low resistance index, suggesting selective inhibition on the 3D7 and K1 strains. Additionally, molecular docking analysis indicated that P. falciparum lactate dehydrogenase could be a potential molecular target for compound 4b.
Article
Agriculture, Multidisciplinary
Huanan Zeng, Wei Zhang, Zhengxing Wang, Wang Geng, Gang Feng, Xiuhai Gan
Summary: In this study, a series of novel pyrazole amide derivatives were synthesized and evaluated for their inhibitory effects on HPPD and herbicidal activities. Some compounds showed excellent inhibitory activities against HPPD and significant herbicidal effects. One compound exhibited strong inhibitory activity against HPPD and was harmless to soybean, cotton, and wheat. Molecular docking and experimental measurements confirmed the interaction between compounds and HPPD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)