Journal
CHIMIA
Volume 67, Issue 12, Pages 891-895Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2013.891
Keywords
CD spectroscopy; Click chemistry; Collagen; Peptides; Proline
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The article summarizes our research devoted to the development of functionalizable collagen using azidoproline-containing model peptides. 'Click chemistry' or Staudinger reduction followed by acylation provided facile access to a range of differently functionalized collagen model peptides bearing e.g. carbohydrates. The research provided not only insight into the factors that are responsible for the high conformational stability of collagen but also a guide in which positions functional moieties are tolerated without or by deliberately disturbing the supramolecular assembly of collagen. The presented research will be useful for the development of collagen-based materials.
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