Poly(lactic acid) Synthesis and Characterization

Poly(lactic acid) (PLA) is a promising biodegradable polymer based on renewable resources. This paper describes scale-up studies to synthesize high molecular weight PLA (>100'000 g/mol) in five steps from commercial lactic acid. The first four steps of this process consist of synthesizing a highly pure precursor, lactide, which can be converted into a high molecular PLA by ring opening polymerization (ROP). We produced PLA with a molecular weight of 109'000 g/mol using this strategy.