Journal
CHIMIA
Volume 65, Issue 11, Pages 868-871Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2011.868
Keywords
Cell biology; Imaging; Protein chemistry; SNAP-tag; Synthetic probes
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Funding
- Swiss National Science Foundation
- EPFL
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The development of molecular probes to visualize cellular processes is an important challenge in chemical biology. One possibility to create such cellular indicators is based on the selective labeling of proteins with synthetic probes in living cells. Over the last years, our laboratory has developed different labeling approaches for monitoring protein activity and for localizing synthetic probes inside living cells. In this article, we review two of these labeling approaches, the SNAP-tag and CLIP-tag technologies, and their use for studying cellular processes.
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