Journal
CHIMIA
Volume 63, Issue 1-2, Pages 19-22Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2009.19
Keywords
Anticancer agents; Histone deacetylase; Natural products; Total synthesis
Categories
Funding
- Swiss National Foundation [21-119750.01]
- Fonds der Chemischen Industrie
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Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the potential to combat cancer on an epigenetic level. The recently reported marine natural product largazole has been recently isolated in trace amounts from cyanobacteria and displays a very potent and selective anti proliferative activity towards a number of cell lines. Several lines of evidence suggested it might act as a histone deacetylase inhibitor These compelling properties have generated considerable interest in the synthetic community which resulted in several total syntheses of largazole. The present review offers a brief overview of the synthetic routes and some early structure-activity relationships.
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