Article
Clinical Neurology
Limin Li, Choong Yi Fong, Wei Kang Lim, Jen Chun Foo, Raja Rizal Azman, Nor Faizal Ahmad Bahuri, Kein Seong Mun
Summary: Gliomatosis cerebri (GC) is a rare form of diffuse glioma that infiltrates extensively and mimics other disorders. Our case report presents a teenager with bi-thalamic and left hippocampal-parahippocampal lesions and symptoms of motor hemiparesis and hemiataxia. Over time, the lesions spread to the bi-temporal, right insular cortex, and bi-frontal cerebral hemisphere, causing multiple cranial palsies and progressive dementia. Histological examination revealed a high-grade anaplastic astrocytoma consistent with GC. This case expands the phenotypic spectrum of GC and highlights the importance of considering GC in children with deep gray matter lesions and accompanying neurological symptoms.
Article
Medicine, General & Internal
Eileen Luders, Christian Gaser, Malin Gingnell, Jonas Engman, Inger Sundstroem Poromaa, Florian Kurth
Summary: This longitudinal study compared the brains of 14 healthy women immediately postpartum and late postpartum, revealing significant volume increases in maternal auditory cortex areas. Additionally, a trend was observed for larger postpartum increases in right-hemispheric regions, possibly linked to the ability to discern the pitch, sound, and volume of a baby's crying.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Behavioral Sciences
Zhizhou Deng, Suiping Wang
Summary: The study investigated sex differences in ASD-related alterations in brain asymmetry. Results showed greater changes in females with ASD compared with males with ASD, indicating a female protective effect. These findings offer insights into the neurobiology of sex differences in ASD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Israel Cohen, Matan Kraus, Gahl Greenberg, Chen Hoffmann, Shai Shrot
Summary: This study found that changes in optic sheath diameter observed on brain MRI in pediatric patients may be related to general anesthesia rather than increased intracranial pressure (ICP).
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Psychology, Clinical
Beatrix Krause-Sorio, Prabha Siddarth, Michaela M. Milillo, Lisa A. Kilpatrick, Katherine L. Narr, Helen Lavretsky
Summary: This study examined the relationships between geriatric depression, brain morphometry, anxiety, and resilience. The results showed that greater gray matter volume in widespread brain regions was associated with reduced anxiety and apathy, as well as increased resilience.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Biology
Iman Beheshti
Summary: This study investigated the anatomical brain changes in individuals with cocaine use disorder (CUD) and how these changes contribute to accelerated brain aging. The findings revealed widespread gray matter atrophy in CUD patients, particularly in the temporal lobe, frontal lobe, insula, and limbic lobe regions. CUD patients also exhibited a higher brain-predicted age difference compared to healthy controls. Regression analysis showed negative changes in gray matter volume associated with brain-PAD in the CUD group.
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Anatomy & Morphology
Ayaka Ando, Peter Parzer, Michael Kaess, Susanne Schell, Romy Henze, Stefan Delorme, Bram Stieltjes, Franz Resch, Romuald Brunner, Julian Koenig
Summary: By longitudinally tracking structural brain development during adolescence, this study found that age best predicted longitudinal changes, while pubertal status had a significant impact on certain brain regions. However, the major limitation of this study was the recruitment of only two cohorts, limiting the investigation of complete trajectories over 6 years of development. Further longitudinal studies in more diverse samples are needed to replicate these findings and explore mechanisms underlying norm-variants in brain development.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Suyog Pol, Serena Liang, Ferdinand Schweser, Ravendra Dhanraj, Anna Schubart, Marilena Preda, Michele Sveinsson, Deepa P. Ramasamy, Michael G. Dwyer, Gisbert Weckbecker, Robert Zivadinov
Summary: The study revealed that treatment with anti-CD20 antibody delayed brain tissue neurodegeneration in the gray matter of huMOG-EAE mice, showing clinical benefits on measures of disease severity.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Oncology
Jiro Akimoto
Summary: Gliomatosis cerebri (GC) is a unique glial tumor that has been recognized as a distinct entity of neuroepithelial tumors. However, in the 2016 WHO classification, it was removed as a specific pathological entity and labeled as a growth pattern of diffuse glioma. Many neuro-oncologists have criticized this decision and argued for the continued inclusion of GC in discussions of brain tumors. In Japan, there are ongoing efforts to conduct multicenter research on GC pathology and develop molecular pathological evidence to support future WHO classifications.
BRAIN TUMOR PATHOLOGY
(2023)
Article
Neuroimaging
Michiel B. de Ruiter, Rachael L. Deardorff, Jeroen Blommaert, Bihong T. Chen, Julie A. Dumas, Sanne B. Schagen, Stefan Sunaert, Lei Wang, Bernadine Cimprich, Scott Peltier, Kim Dittus, Paul A. Newhouse, Daniel H. Silverman, Gwen Schroyen, Sabine Deprez, Andrew J. Saykin, Brenna C. McDonald
Summary: Brain gray matter reductions were observed after breast cancer chemotherapy, with different spatial extent and degree depending on the methods used. The chemotherapy group also showed brain aging and gray matter recovery relative to the non-cancer control group. These findings contribute to the assessment of treatment strategies' risks and benefits.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Stephen G. Gordon, Blake E. Butler, Stephen G. Lomber
Summary: This study compares cortical thickness patterns between hearing and deaf cats, revealing that deaf cats have thicker dorsal auditory cortex and thinner ventral regions compared to hearing cats.
Article
Pathology
Daniel R. Rissi, Taryn A. Donovan, Brian F. Porter, Chad Frank, Andrew D. Miller
Summary: Gliomatosis cerebri is a subtype of glioma characterized by diffuse infiltration within the brain parenchyma, rather than specific architectural distortion. Clinical cases in canines have shown variable morphological and immunohistochemical features, suggesting a need for further research to confirm its classification as a distinct infiltrative growth pattern of canine glioma.
VETERINARY PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Elisabeth Solana, Eloy Martinez-Heras, Victor Montal, Eduard Vilaplana, Elisabet Lopez-Soley, Joaquim Radua, Nuria Sola-Valls, Carmen Montejo, Yolanda Blanco, Irene Pulido-Valdeolivas, Maria Sepulveda, Magi Andorra, Joan Berenguer, Pablo Villoslada, E. H. Martinez-Lapiscina, Ferran Prados, Albert Saiz, Juan Fortea, Sara Llufriu
Summary: In multiple sclerosis, the diffusion rate and volume changes of gray matter show differential spatial predominance in different brain regions as the disease progresses. Furthermore, microstructural integrity loss and atrophy at different stages are associated with white matter lesion load and physical and cognitive disability.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Aashim Bhatia, Vincent Kyu Lee, Yongxian Qian, Michael J. Paldino, Rafael Ceschin, Jasmine Hect, James M. Mountz, Dandan Sun, Gary Kohanbash, Ian F. Pollack, Regina Jakacki, Fernando Boada, Ashok Panigrahy
Summary: Na-23 MRI can be used to compare sodium concentrations between pediatric gliomas and non-neoplastic brain tissues. Dual echo Na-23 MRI improves tissue conspicuity of bound sodium concentration relative to TSC imaging.
Editorial Material
Clinical Neurology
M. Vinchon
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Matthieu Vinchon, Melodie-Anne Karnoub, Nathalie Noule, Marie-Emilie Lampin
Summary: The study compared AHI cases with and without confession, finding that the confession group had more severe clinical symptoms and outcomes. While there were no significant differences in the child and caregivers' previous medical history between the two groups, the confession status might be influenced by the severity of the inflicted injuries.
CHILDS NERVOUS SYSTEM
(2022)
Letter
Clinical Neurology
Matthieu Vinchon, Melodie-Anne Karnoub, Nathalie Noule, Marie-Emilie Lampin
Summary: The authors respond to criticisms of their study's methodology by a Swedish expert. They acknowledge some limitations but maintain their conclusions, stating that the diagnosis was correct in both confession and denial groups, and denial was more difficult in severe cases.
CHILDS NERVOUS SYSTEM
(2022)
Letter
Oncology
Gauthier Toutain, Victoria Min, Angelique Rome, Nicolas Andre
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Fanny Cahn, Gabriel Revon-Riviere, Victoria Min, Angelique Rome, Pauline Filaine, Annick Pelletier, Sylvie Abed, Jean-Claude Gentet, Arnauld Verschuur, Nicolas Andre
Summary: This study retrospectively analyzed the feasibility and results of tumor molecular profiling using liquid biopsy in pediatric oncology patients. The results showed that this method was feasible in pediatric patients and successfully identified actionable mutations in a subset of patients.
Letter
Clinical Neurology
Matthieu Vinchon
CHILDS NERVOUS SYSTEM
(2022)
Editorial Material
Clinical Neurology
Matthieu Vinchon
CHILDS NERVOUS SYSTEM
(2022)
Letter
Oncology
Nicolas Andre
PEDIATRIC BLOOD & CANCER
(2023)
Retraction
Clinical Neurology
Matthieu Vinchon, Melodie-Anne Karnoub, Nathalie Noule, Marie-Emilie Lampin
CHILDS NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Matthieu Vinchon, Amelie Toubol, Melodie-Anne Karnoub, Rabih Aboukais, Xavier Leclerc, Nicolas Reyns
Summary: This retrospective study evaluated the management and outcomes of URCAVM in children from 2001 to 2021. Out of 36 patients, 12 were managed by observation and 24 underwent different first-line treatments. After a mean follow-up of 63 months, 58% of the treatment group achieved complete cure, while 2 patients in the observation group experienced cerebral hemorrhage. The treatment group also had some patients with new neurological deficits, but most cases showed improvement in headache symptoms.
Article
Oncology
Eric Moreddu, Nicolas Andre, Romain Appay
Summary: We report two cases of pediatric mammary-analog secretory carcinoma (MASC) in which the diagnosis was challenging, but achieved by identifying the ETV6::NTRK3 fusion transcript. Both patients, a male operated on at age 8 and a female operated on at 12, are in remission 2 years after surgery. Considering the successful results of TRK inhibitor treatments in adult MASC and pediatric tumors expressing an ETV6::NTRK3 fusion, they should probably be recommended as the first-line treatment in cases with potential serious sequelae or metastatic disease that require surgery.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Medicine, General & Internal
Camille Winnicki, Pierre Leblond, Franck Bourdeaut, Anne Pagnier, Gilles Paluenzela, Pascal Chastagner, Gwenaelle Duhil-De Benaze, Victoria Min, Helene Sudour-Bonnange, Catherine Piette, Natacha Entz-Werle, Sylvie Chabaud, Nicolas Andre
Summary: This study retrospectively analyzed pediatric patients with relapsed high-risk brain tumors treated with the METMAT or METMAT-like regimen. It found that this treatment approach can lead to sustained control of the tumors, with the best outcomes observed at first relapse.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Pierre Leblond, Emmanuelle Tresch-Bruneel, Alicia Probst, Nadege Neant, Caroline Solas, Arthur Sterin, Thomas Boulanger, Isabelle Aerts, Cecile Faure-Conter, Anne-Isabelle Bertozzi, Pascal Chastagner, Natacha Entz-Werle, Emilie De Carli, Marie-Cecile Le Deley, Gauthier Bouche, Nicolas Andre
Summary: This study tested the repurposing of two non-anticancer drugs to provide less toxic therapeutic options for children with gliomas. The recommended phase II dose of fluvastatin in combination with celecoxib for children with gliomas is 6mg/kg/day, with a fixed daily dose of celecoxib depending on weight. This combination may be explored as a maintenance treatment in low-grade glioma patients to delay tumor recurrence.
Article
Immunology
Caroline Donze, Victoria Min, Laetitia Ninove, Xavier de Lamballerie, Gabriel Revon Riviere, Arnauld Verschuur, Paul Saultier, Nicolas Andre
Summary: This study evaluated the adverse effects and immunological response associated with BNT162B2 vaccination in children and young adults with cancer. The results showed that most patients had an increase in antibody levels and the vaccine was effective in neutralizing the SARS-CoV-2 virus. In addition, COVID-19 infections after vaccination were mild in all cases.
Letter
Biochemistry & Molecular Biology
Birgit Geoerger, Xavier Paoletti, Francisco Bautista, Susanne A. Gatz, Lynley V. Marshall, Nicolas Andre, Pablo Berlanga, Stephane Ducassou, Claudia Pasqualini, Michela Casanova, C. Michel Zwaan, Karsten Nysom, Jonathan Rubino, Delphine Vuillier-Le Goff, Baptiste Archambaud, Samuel Abbou, Gudrun Schleiermacher, Christelle Dufour, Patricia Blanc, Natalie Hoog-Labouret, Agnes Buzyn, Gilles Vassal