Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Erberto Carluccio, Angela Beatrice Scardovi, Frank Lloyd Dini, Andrea Rossi, Calogero Falletta, Laura Scelsi, Alessandra Greco, Pier Luigi Temporelli
Summary: In stable HFrEF outpatients, re-assessment of LV filling pattern, PASP and TAPSE using Doppler echocardiography provides additional prognostic information beyond baseline evaluation, offering better prognostic stratification.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Hematology
Amira Zawia, Nadine D. Arnold, Laura West, Josephine A. Pickworth, Helena Turton, James Iremonger, Adam T. Braithwaite, Jaime Canedo, Simon A. Johnston, A. A. Roger Thompson, Gaynor Miller, Allan Lawrie
Summary: The study showed that reducing CD68 macrophages globally affects the development of experimental PAH, particularly in male mice. Imbalance of macrophages can lead to changes in the PAH phenotype.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alessia Lena, Ursula Wilkenshoff, Sara Hadzibegovic, Jan Porthun, Lukas Roesnick, Ann-Kathrin Froehlich, Tanja Zeller, Mahir Karakas, Ulrich Keller, Johann Ahn, Lars Bullinger, Hanno Riess, Stuart D. Rosen, Alexander R. Lyon, Thomas F. Luescher, Matthias Totzeck, Tienush Rassaf, Daniel Burkhoff, Mandeep R. Mehra, Jeroen J. Bax, Javed Butler, Frank Edelmann, Wilhelm Haverkamp, Stefan D. Anker, Milton Packer, Andrew J. S. Coats, Stephan von Haehling, Ulf Landmesser, Markus S. Anker
Summary: This study found that cancer patients have cardiac wasting and decreased heart function. Low left ventricular mass is associated with poor functional status and increased all-cause mortality in cancer patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Taeger, Jennifer Franke, Norbert Frey, Lutz Frankenstein, Hanna Froehlich
Summary: Obesity is associated with better outcomes in heart failure patients, while cachexia is linked to higher mortality. The prognostic impact of gradual, long-term weight changes in stable heart failure patients is not well understood.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Yuki Saito, Yuto Omae, Saki Mizobuchi, Hidesato Fujito, Masatsugu Miyagawa, Daisuke Kitano, Kazuto Toyama, Daisuke Fukamachi, Jun Toyotani, Yasuo Okumura
Summary: Our study assessed the prognostic value of estimated pulmonary arterial wedge pressure (ePAWP) calculated by a deep learning approach in patients with acute decompensated heart failure (ADHF). The results demonstrated that a higher ePAWP at discharge and a smaller decrease in ePAWP from admission to discharge were significantly associated with higher event rates.
Article
Medicine, General & Internal
Christoph Ahlgrim, Sascha Kocher, Jan Minners, Nikolaus Jander, Gianluigi Savarese, Franz-Josef Neumann, Thomas Arentz, Amir Jadidi, Bjoern Mueller-Edenborn
Summary: Invasive exercise testing can improve the prediction of mortality in patients with heart failure. Patients with a favorable response to exercise have a relatively low mortality, regardless of left ventricular systolic function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Joao Enes Silva, Nuno Melo, Ana Isabel Ferreira, Clara Silva, Diana Oliveira, Maria Joao Lume, Joana Pereira, Jose Paulo Araujo, Patricia Lourenco
Summary: This study investigated neurohormonal modulation therapy in older patients with chronic heart failure. The findings showed that beta-blockers and renin-angiotensin system inhibitors increased survival rate in very old patients with systolic dysfunction.
Article
Cardiac & Cardiovascular Systems
Yuki Yamagata, Satoshi Ikeda, Sanae Kojima, Yuki Ueno, Tomoo Nakata, Seiji Koga, Chikara Ohno, Tsuyoshi Yonekura, Tsuyoshi Yoshimuta, Takako Minami, Hiroaki Kawano, Koji Maemura
Summary: This study found that patients with chronic thromboembolic pulmonary hypertension (CTEPH) show more evident right ventricular (RV) dyssynchrony compared to patients with pulmonary arterial hypertension (PAH). The reduced pulmonary arterial compliance and increased pulse pressure may delay RV free wall motion and cause RV dyssynchrony.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Hongyang Pi, Lu Xia, David D. Ralph, Samuel G. Rayner, Ali Shojaie, Peter J. Leary, Sina A. Gharib
Summary: In this study, metabolic profiling was used to identify the association between plasma metabolomic profiles and right ventricular dilation, mortality, and measures of disease severity in patients with pulmonary arterial hypertension (PAH). The polyamine, histidine, and sphingomyelin metabolic pathways were found to be associated with RV dilation, mortality, and disease severity.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
Manuel Mendez-Bailon, Noel Lorenzo-Villalba, Jorge Rubio-Garcia, Maria Carmen Moreno-Garcia, Guillermo Ropero-Luis, Eduardo Martinez-Litago, Raul Quiros-Lopez, Sara Carrascosa-Garcia, Alvaro Gonzalez-Franco, Emmanuel Andres, Jesus Casado-Cerrada, Manuel Montero-Perez-Barquero
Summary: The presence of a family caregiver for elderly patients with heart failure was associated with a lower readmission rate and a lower mortality rate. Additionally, elderly patients with good cognitive and functional status can be their own caregivers to achieve good health outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Remigiusz Kazimierczyk, Piotr Szumowski, Stephan G. Nekolla, Piotr Blaszczak, Lukasz A. Malek, Barbara Milosz-Wieczorek, Jolanta Misko, Dorota Jurgilewicz, Marcin Hladunski, Malgorzata Knapp, Bozena Sobkowicz, Janusz Mysliwiec, Ryszard Grzywna, Wlodzimierz J. Musial, Karol A. Kaminski
Summary: The study found that RV glucose uptake in PET and decreased RVEF can identify PAH patients with worse prognosis. Combining parameters from PET and MRI may help identify higher-risk patients who could benefit from escalated therapy, but this hypothesis needs prospective validation.
Review
Respiratory System
Katarina Zeder, Chiara Banfi, Gregor Steinrisser-Allex, Bradley A. Maron, Marc Humbert, Gregory D. Lewis, Andrea Berghold, Horst Olschewski, Gabor Kovacs
Summary: This study aimed to identify parameters related to abnormal haemodynamic response during exercise, and provide optimal prognostic and differential-diagnostic value. The findings indicated that mPAP/CO slope, PAWP/CO slope, and peak cardiac index (or CO) were the most consistent prognostic haemodynamic parameters. The study also established cut-off values for survival and cardiovascular events. Age was found to have a significant impact on the upper limits of normal for mPAP/CO slope and PAWP/CO slope.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Medicine, General & Internal
Silvana Elena Hojda, Irina Camelia Chis, Simona Clichici
Summary: PAH is a severe medical condition that requires monitoring and treatment. Biomarkers play an important role in diagnosis, prognosis, and disease progression, providing valuable information through blood and urine tests.
Article
Cardiac & Cardiovascular Systems
Giuseppe Vergaro, Alberto Aimo, James L. Januzzi, A. Mark Richards, Carolyn S. P. Lam, Roberto Latini, Lidia Staszewsky, Inder S. Anand, Thor Ueland, Hans-Peter Brunner-La Rocca, Antoni Bayes-Genis, Josep Lupon, Rudolf A. de Boer, Akiomi Yoshihisa, Yasuchika Takeishi, Ida Gustafsson, Kai M. Eggers, Kurt Huber, Greg D. Gamble, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P. Ng, Richard Troughton, Robert N. Doughty, Michele Emdin, Claudio Passino
Summary: This study assessed the influence and prognostic value of three biomarkers (NT-proBNP, hs-TnT, and sST2) in patients with HF and COPD. The results showed that patients with COPD had higher levels of NT-proBNP and hs-TnT, but no significant difference in sST2 levels. Regardless of COPD status, all three biomarkers were predictive of prognosis in HF patients.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Taishi Dotare, Sayaki Ishiwata, Yuya Matsue, Yutaka Nakamura, Tsutomu Sunayama, Daichi Maeda, Shoichiro Yatsu, Shoko Suda, Takao Kato, Masaru Hiki, Takatoshi Kasai, Tohru Minamino
Summary: This study found that the coexistence of glomerular dysfunction and tubular dysfunction is associated with higher mortality rates in patients with acute heart failure. Isolated glomerular dysfunction and tubular dysfunction are also independently associated with increased risk of all-cause mortality.
CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Valentina Mercurio, Andrea Attanasio, Gaetano Asile, Carlo Gabriele Tocchetti, Stefania Paolillo
Summary: There is a strong bidirectional relationship between diabetes mellitus (DM) and heart failure (HF), with DM activating multiple molecular and pathophysiological mechanisms that can damage the heart in the long term. However, the prognostic role of DM in chronic and acute HF is still unclear, with gaps in evidence due to the heterogeneity of patient phenotypes and the necessity to better characterize individual patients and their comorbidities. This review aims to summarize the negative impact of DM on HF and analyze available data on the prognostic implications in both chronic and acute HF.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Leonardo De Luca, Michele M. Gulizia, Domenico Gabrielli, Jennifer Meessen, Luisa Mattei, Maurizio D'Urbano, Furio Colivicchi, Pier L. Temporelli, Claudio Borghi, Giovambattista Desideri
Summary: Using data from a nationwide registry on patients with chronic coronary syndromes, this study assessed the impact of serum uric acid levels on quality of life and major adverse cardiovascular events. The results showed that patients with hyperuricemia had a greater burden of cardiovascular disease and worse quality of life. However, serum uric acid levels did not significantly influence the higher rates of cardiovascular mortality, hospitalization for heart failure, and major adverse cardiovascular events observed during the 1-year follow-up.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Roberto Badagliacca, Franz Rischard, Francesco Lo Giudice, Luke Howard, Silvia Papa, Gabriele Valli, Giovanna Manzi, Susanna Sciomer, Paolo Palange, Joe G. N. Garcia, Rebecca Vanderpool, Rocco Rinaldo, Beatrice Vigo, Michael Insel, Francesco Fedele, Carmine Dario Vizza
Summary: This study proposes a risk scoring model based on the stroke volume index (SVI) and peak oxygen uptake (VO2 peak) to further stratify intermediate-risk patients with idiopathic pulmonary arterial hypertension (PAH). Patients can be divided into three groups based on the risk score, with different prognostic outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Neuroimaging
Matteo Bonatti, Fabio Lombardo, Riccardo Valletta, Alessio Comai, Benedetto Petralia, Giacomo Avesani, Enrica Franchini, Andrea Rossi, Nicoletta De Santis, Massimo Guerriero, Federica Ferro
Summary: This study assessed the impact of sarcopenia and myosteatosis on neurological outcomes and mortality in patients with successfully reperfused acute ischemic stroke. The results showed that low masseter attenuation was an independent negative predictor for 90-day mortality and poor neurological outcome.
NEURORADIOLOGY JOURNAL
(2023)
Article
Cell Biology
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy-Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer-Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Summary: Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. This study shows that endogenous genotoxic stress contributes to the development of cardiomyopathy by activating the p53 pathway and increasing oxidative stress, leading to cardiac myocyte apoptosis, dilated cardiomyopathy, and sudden death.
Letter
Critical Care Medicine
Rebecca R. Vanderpool, Michael Insel, Saad Kubba, Franz P. Rischard
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Stefano Ghio, Mauro Acquaro, Piergiuseppe Agostoni, Giuseppe Ambrosio, Erberto Carluccio, Vincenzo Castiglione, Davide Colombo, Michele D'Alto, Santo Delle Grottaglie, Frank Lloyd Dini, Michele Emdin, Martino Fortunato, Andrea Igoren Guaricci, Francesca Jacoangeli, Alberto M. Marra, Stefania Paolillo, Sivia Papa, Luca Vicini Scajola, Michele Correale, Alberto Palazzuoli
Summary: For a long time, cardiologists have underestimated the role of the right heart in heart failure caused by left heart disease. However, the importance of evaluating right ventricular structure and function in left heart failure is now well recognized and emphasized in the latest heart failure guidelines. Yet, there are still unanswered questions about which imaging techniques and parameters should be used to assess the severity of RV dysfunction, and whether less commonly used diagnostic tools have a role in this field.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea M. D. 'Armini, Maurizio Pin, Anna Celentano, Leslie J. Te Masiglat, Ermelinda Borrelli, Benedetta Vanini, Catherine Klersy, Giuseppe Silvaggio, Cristian Monterosso, Alessia Alloni, Carlo Pellegrini, Stefano Ghio
Summary: This study showed that in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy, a higher number of treated pulmonary artery branches is associated with better hemodynamic and clinical outcomes after surgery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Manuel J. Richter, Federico Fortuni, Fawaz Alenezi, Michele D'Alto, Roberto Badagliacca, Nathan W. Brunner, Arie P. van Dijk, Philipp Douschan, Henning Gall, Stefano Ghio, Francesco Lo Giudice, Ekkehard Grunig, Francois Haddad, Luke Howard, Sudarshan Rajagopal, Niels Stens, Davide Stolfo, Dick H. J. Thijssen, Carmine Dario Vizza, Roham T. Zamanian, Liang Zhong, Werner Seeger, Hossein A. Ghofrani, Khodr Tello
Summary: A meta-analysis of 35 studies found that right atrial (RA) imaging assessment is a relevant prognostic marker in patients with pulmonary hypertension (PH). RA area, RA indexed area, RA peak longitudinal strain, and RA total emptying fraction were significantly associated with combined end-points including death, clinical worsening, and/or lung transplantation. RA volume and volume index showed marginal significant associations.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Erberto Carluccio, Matteo Cameli, Andrea Rossi, Frank Lloyd Dini, Paolo Biagioli, Anna Mengoni, Francesca Jacoangeli, Giulia Elena Mandoli, Maria Concetta Pastore, Caterina Maffeis, Giuseppe Ambrosio
Summary: This study developed a machine learning algorithm that integrated peak atrial longitudinal strain (PALS) with guideline-recommended diastolic variables to improve the classification and prognostic stratification of heart failure patients. The algorithm showed better predictive ability for adverse events compared to guideline-based classification, regardless of ejection fraction status.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Franz P. Rischard, Roberto J. Bernardo, Rebecca R. Vanderpool, Deborah H. Kwon, Tushar Acharya, Margaret M. Park, Austin Katrynuik, Michael Insel, Saad Kubba, Roberto Badagliacca, A. Brett Larive, Robert Naeije, Joe G. N. Garcia, Gerald J. Beck, Serpil C. Erzurum, Robert P. Frantz, Paul M. Hassoun, Anna R. Hemnes, Nicholas S. Hill, Evelyn M. Horn, Jane A. Leopold, Erika B. Rosenzweig, W. H. Wilson Tang, Jennifer D. Wilcox
Summary: The aim of this study is to assess the clinical relevance of a proposed definition for RV functional recovery (RVFnRec). A decrease in RV end-diastolic volume of -15 mL and an increase in compliance had the best predictive value for RVFnRec. RVFnRec is associated with improvements in exercise capacity and clinical worsening.
CIRCULATION-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Caterina Maffeis, Andrea Rossi, Stefano Bonapace, Lorenzo Cannata, Elvin Tafciu, Mariantonietta Cicoira, Pier Luigi Temporelli
Summary: This study analyzed the influence of aortic stiffness on disproportionate secondary mitral regurgitation (sMR) and found that aortic stiffness may play a role in the discrepancy between mitral valve lesion severity and sMR hemodynamic burden. Higher aortic stiffness was associated with higher-than-expected regurgitant fraction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Stefano Bonapace, Laura Lanzoni, Andrea Rossi, Carmelo Ciccio, Mariantonietta Cicoira, Clementina Dugo, Caterina Maffeis, Filippo Valbusa, Guido Canali, Massimo Guerriero, Giulio Molon
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medicine, General & Internal
Simona Giubilato, Fabiana Luca, Maurizio Giuseppe Abrignani, Laura Gatto, Carmelo Massimiliano Rao, Nadia Ingianni, Francesco Amico, Roberta Rossini, Giorgio Caretta, Stefano Cornara, Irene Di Matteo, Concetta Di Nora, Silvia Favilli, Anna Pilleri, Andrea Pozzi, Pier Luigi Temporelli, Marco Zuin, Antonio Francesco Amico, Carmine Riccio, Massimo Grimaldi, Furio Colivicchi, Fabrizio Oliva, Michele Massimo Gulizia
Summary: Chronic coronary syndrome (CCS) is a clinical presentation of coronary artery disease (CAD) and is the leading cause of mortality worldwide. Despite advances in CAD treatment, patients with CCS remain at an elevated risk of residual cardiovascular events. Understanding the level and type of residual cardiovascular risk is crucial for appropriate diagnostic tests and follow-up procedures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Fabiana Luca, Fabrizio Oliva, Maurizio Giuseppe Abrignani, Stefania Angela Di Fusco, Iris Parrini, Maria Laura Canale, Simona Giubilato, Stefano Cornara, Martina Nesti, Carmelo Massimiliano Rao, Andrea Pozzi, Giulio Binaghi, Alessandro Maloberti, Roberto Ceravolo, Irma Bisceglia, Roberta Rossini, Pier Luigi Temporelli, Antonio Francesco Amico, Raimondo Calvanese, Sandro Gelsomino, Carmine Riccio, Massimo Grimaldi, Furio Colivicchi, Michele Massimo Gulizia
Summary: DOACs are widely used in anticoagulant therapy for atrial fibrillation and venous thromboembolism, with advantages over other treatments. However, several considerations, including drug interactions and patient-specific factors, need to be taken into account in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2023)