Article
Respiratory System
Patrick M. Wieruszewski, Heather P. May, Steve G. Peters, Ognjen Gajic, William J. Hogan, Ross A. Dierkhising, Hassan B. Alkhateeb, Hemang Yadav
Summary: PERDS is a common complication following autologous HCT, associated with higher mortality and healthcare utilization. Radiographic evidence of pulmonary involvement precedes hematopoietic recovery. Risk factors for PERDS include female sex, number of platelet transfusions, and more rapid engraftment.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Review
Oncology
Taylor Fitch, Kasiani C. Myers, Maya Dewan, Christopher Towe, Christopher Dandoy
Summary: The number of disorders benefiting from hematopoietic stem cell transplantation (HSCT) has increased, leading to a rise in HSCT procedures. Pulmonary complications, both infectious and non-infectious, are a significant concern after HSCT, with different diagnostic and treatment approaches required for each type of complication.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Masuho Saburi, Kumi Oshima, Kuniko Takano, Yoshitaka Inoue, Kaito Harada, Naoyuki Uchida, Takahiro Fukuda, Noriko Doki, Kazuhiro Ikegame, Yayoi Matsuo, Yuta Katayama, Yukiyasu Ozawa, Ken-ichi Matsuoka, Toshiro Kawakita, Yasuo Mori, Takahide Ara, Hirohisa Nakamae, Takafumi Kimura, Yoshinobu Kanda, Yoshiko Atsuta, Masao Ogata
Summary: Stenotrophomonas maltophilia (S. maltophilia) is a multidrug-resistant Gram-negative bacillus that commonly causes infections after allogeneic hematopoietic stem cell transplantation (HSCT). A retrospective study in Japan found that the cumulative incidence of S. maltophilia infection at 100 days after HSCT was 2.2%. Cord blood transplantation (CBT) was identified as the strongest risk factor, and S. maltophilia infection before neutrophil engraftment was associated with poor survival.
ANNALS OF HEMATOLOGY
(2023)
Article
Pediatrics
Irina Zaidman, Tamar Shaziri, Dina Averbuch, Ehud Even-Or, Yael Dinur-Schejter, Adeeb NaserEddin, Rebecca Brooks, Bella Shadur, Aharon Gefen, Polina Stepensky
Summary: Infectious and noninfectious neurological complications are significant factors affecting morbidity and mortality in children following allogeneic HSCT. Further research is needed to understand the risk factors and outcomes of different neurological complications regarding sequelae and survival.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Fabian J. S. van der Velden, Frederik van Delft, Stephen Owens, Judit Llevadias, Michael McKean, Lindsey Pulford, Yusri Taha, Grace Williamson, Quentin Campbell-Hewson, Sophie Hambleton, Rebecca Payne, Christopher Duncan, Catriona Johnston, Jarmila Spegarova, Marieke Emonts
Summary: In general, SARS-CoV-2 infection in children, including immunocompromised children, tends to be mild. However, a small percentage of pediatric patients may develop severe respiratory failure and require intensive care treatment.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Mohammad Rafiee, Fatemeh Amiri, Mohammad Hossein Mohammadi, Abbas Hajifathali
Summary: This study investigated the predictive value of circulatory microRNAs (miRs) expression for outcomes of autologous hematopoietic stem cell transplantation (AHSCT). The results showed that the expression of miR-125b was associated with relapse, high lactate dehydrogenase (LDH), and high erythrocyte sedimentation rate (ESR). This finding provides a potential opportunity for prognosis evaluation and new targeted therapy after AHSCT.
Article
Oncology
Courtney M. Rowan, Julie C. Fitzgerald, Asya Agulnik, Matt S. Zinter, Matthew P. Sharron, James E. Slaven, Erin M. Kreml, Rajinder P. S. Bajwa, Kris M. Mahadeo, Jerelyn Moffet, Keiko M. Tarquinio, Marie E. Steiner
Summary: Respiratory rate at 4 hours and vasoactive use were identified as independent risk factors of NIPPV failure in this study. Additionally, 14% of patients experienced a cardiac arrest during intubation, with some others arresting prior to intubation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Kate Elizabeth Therkelsen, Lauren R. Schaff, Subhiksha Nandakumar, Antonio M. P. Omuro, Lisa M. DeAngelis, Christian Grommes
Summary: This study reports the long-term survival of patients with newly diagnosed immunocompetent primary CNS lymphoma. The results showed that most patients had stable disease status after receiving medication and high-dose chemotherapy, and no disease recurrence was observed in long-term follow-up.
Review
Clinical Neurology
Yoji Hoshina, Jonathan Galli, Ka-Ho Wong, Tibor Kovacsovics, Mary Steinbach, Karen L. Salzman, Joseph Scott McNally, Eric Lancaster, M. Mateo Paz Soldan, Stacey L. Clardy
Summary: This study reported 3 cases of anti-GABA(A)R encephalitis in multiple myeloma (MM) patients with a history of autologous hematopoietic stem cell transplant (aHSCT). The patients all presented with new seizures, altered cognitive function, and multifocal nonenhancing brain lesions on MRI.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Andrology
Lindsey J. Anderson, Dorota Migula, Rebecca Abay, Stephanie Crabtree, Solomon A. Graf, Alvin M. Matsumoto, Thomas R. Chauncey, Jose M. Garcia
Summary: AHSCT is associated with sexual dysfunction and hypogonadism. Estrogens and androgens are both adversely affected by AHSCT, and may predict sexual dysfunction. Larger, controlled trials are needed to confirm the association between changes in sex hormones and long-term sexual function recovery.
Article
Oncology
Heidi J. Hansen, Cherry Estilo, Adepitan Owosho, Armand Karl Solano, Joseph Randazzo, Joseph Huryn, SaeHee K. Yom
Summary: Dental evaluation and management prior to hematopoietic stem cell transplant (HSCT) are crucial for identifying and treating potentially life-threatening infections. By using a conservative approach based on an infection risk classification system, a low rate of odontogenic complications was observed at Memorial Sloan Kettering Cancer Center.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Biochemistry & Molecular Biology
Emanuele Durante-Mangoni, Domenico Iossa, Valeria Iorio, Irene Mattucci, Umberto Malgeri, Daniela Pinto, Roberto Andini, Ciro Maiello, Rosa Zampino
Summary: Post-transplant diabetes mellitus (PTDM) is a common complication after heart transplant, sharing similarities with type 2 diabetes but also having specific causes. This study evaluated the incidence and risk factors of PTDM and studied its relationship with glucose metabolic alterations and heart transplant outcomes. The results showed that PTDM is closely related to BMI increase, metabolic syndrome development, and recipient survival.
Article
Microbiology
Jessica Gill, Alessandro Busca, Natascia Cinatti, Roberto Passera, Chiara Maria Dellacasa, Luisa Giaccone, Irene Dogliotti, Sara Manetta, Silvia Corcione, Francesco Giuseppe De Rosa
Summary: This study retrospectively observed allo-HSCT recipients and found that bacterial bloodstream infections pose a major risk to these patients, with multidrug-resistant organisms being a significant cause of morbidity and mortality. Independent risk factors for BSI occurrence include high and very high disease risk index, haploidentical transplant, and antibacterial prophylaxis.
Article
Cell Biology
Matt S. Zinter, A. Birgitta Versluys, Caroline A. Lindemans, Madeline Y. Mayday, Gustavo Reyes, Sara Sunshine, Marilynn Chan, Elizabeth K. Fiorino, Maria Cancio, Sabine Prevaes, Marina Sirota, Michael A. Matthay, Sandhya Kharbanda, Christopher C. Dvorak, Jaap J. Boelens, Joseph L. DeRisi
Summary: This study reveals the association between the metatranscriptomes of bronchoalveolar lavage (BAL) and pretransplant lung function in pediatric allogeneic hematopoietic cell transplantation (HCT). Abnormal pulmonary function and dysregulated microbial composition and gene expression in BAL are associated with post-HCT mortality. These findings highlight the potential importance of microbiome depletion and epithelial gene expression in the development of pre-HCT lung dysfunction.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Surgery
Hanyu Wang, Ruyi Xing, Xiaohong Li, Ning Cai, Mengyuan Tan, Meijun Shen, Min Li, Qiufeng Wang, Jizhou Wang, Chen Gao, Yuanhang Luan, Min Zhang, Yanhu Xie
Summary: Postoperative pulmonary complications (PPCs) are common after liver resection. Although laparoscopic liver resection (LLR) has reduced the incidence of PPCs, the rate of PPCs after LLR remains high and the risk factors are unclear. This study identified smoking, location of lesion, duration of liver ischemia, and intraoperative hypothermia as independent risk factors for PPCs after LLR.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)