Article
Multidisciplinary Sciences
Hyun Ho Kim, Se In Sung, Mi Sun Yang, Yea Seul Han, Hye Seon Kim, So Yoon Ahn, Ga Won Jeon, Yun Sil Chang, Won Soon Park
Summary: This study suggests that early pulmonary hypertension in extremely preterm infants may increase the risk of death before 36 weeks post-menstrual age or late pulmonary hypertension in bronchopulmonary dysplasia patients. Monitoring early PH and other complications can help prevent adverse outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Shiran S. Moore, Gabriela De Carvalho Nunes, Adrian Dancea, Punnanee Wutthigate, Jessica Simoneau, Marc Beltempo, Guilherme Sant'Anna, Gabriel Altit
Summary: Altered cardiac function and increased pulmonary pressure within the first 21 days after birth are associated with the combined outcome of death/severe BPD and death/BPD-related PH in extremely premature infants.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Masato Ito, Shin Kato, Makoto Saito, Naoyuki Miyahara, Hirokazu Arai, Fumihiko Namba, Erika Ota, Hidehiko Nakanishi
Summary: This scoping review aimed to screen available evidence regarding perinatal risk factors associated with the development and severity of bronchopulmonary dysplasia (BPD). The results identified several risk factors for BPD, including male sex, maternal hypertensive disorders of pregnancy, low gestational age, small-for-gestational-age birth weight, and mechanical ventilation. Rating: 8 out of 10.
Article
Medicine, General & Internal
Seong Hee Oh, Hyun-Seung Jin, Chan-Hoo Park
Summary: This study investigates the perinatal characteristics, morbidities, and mortality of extremely preterm infants with severe air leak syndrome (sALS) and estimates the risk of mortality based on gestational age (GA). The study finds that the incidence of sALS is inversely related to GA, and extremely preterm infants with sALS have higher mortality rates and a higher risk of complications such as bronchopulmonary dysplasia and major brain injury.
Article
Medicine, General & Internal
Liron Borenstein-Levin, Noa Avishay, Orit Soffer, Shmuel Arnon, Arieh Riskin, Gil Dinur, Karen Lavie-Nevo, Ayala Gover, Amir Kugelman, Ori Hochwald
Summary: Extremely low birth weight (ELBW) premature infants are at risk of hypocarbia and hypercarbia. This study evaluates the correlation between transcutaneous CO2 (TcCO2) monitoring and blood gas CO2 (bgCO2) measurements in ELBW infants. The results show a moderate correlation and good agreement between TcCO2 and bgCO2 values in the 25-70 mmHg TcCO2 range. TcCO2 can be used as a complementary tool to assess CO2 levels and trends in premature infants, but blood gas sampling is still necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Pranav Jani, Umesh Mishra, Julia Buchmayer, Karen Walker, Duygu Gozen, Rajesh Maheshwari, Daphne D'cruz, Krista Lowe, Audrey Wright, James Marceau, Mihaela Culcer, Archana Priyadarshi, Adrienne Kirby, James E. Moore, Ju Lee Oei, Vibhuti Shah, Umesh Vaidya, Abdelmoneim Khashana, Sunit Godambe, Fook Choe Cheah, Wenhao Zhou, Hu Xiaojing, Muneerah Satardien
Summary: There is significant variation in thermoregulation and golden hour practices for extremely preterm infants based on geographic region, country's income status, and lowest gestational age. Efforts should be made to reduce practice variation and align with international guidelines.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Sandra E. Juul, Thomas R. Wood, Bryan A. Comstock, Krystle Perez, Semsa Gogcu, Mihai Puia-Dumitrescu, Sara Berkelhamer, Patrick J. Heagerty
Summary: Understanding the causes and circumstances of death in extremely preterm infants is crucial for healthcare practitioners. This study retrospectively examined a cohort of infants born between 24 and 27 weeks of gestation to determine the risk factors, causes, timing, and circumstances of death. The study found that respiratory distress or failure, pulmonary hemorrhage, necrotizing enterocolitis, catastrophic intracranial hemorrhage, sepsis, and sudden unexplained death were the primary causes of death. The risk of death decreased over time, and preterm labor was associated with a decreased hazard of death. Clinical factors such as low birth weight, low Apgar score, sick appearance at birth, necrotizing enterocolitis, pulmonary hemorrhage, severe intracranial hemorrhage, and severe sepsis were also associated with death.
Article
Ophthalmology
Ye He, Moritz Pettenkofer, Alison Chu, Srinivas R. Sadda, Giulia Corradetti, Irena Tsui
Summary: This study used optical coherence tomography to investigate foveal development in treatment-naive extremely preterm infants. The results showed that the foveal inner retina of extremely preterm infants was thicker and the foveal pit was shallower compared to non-preterm infants. The gestational age of 28 weeks seems to be a critical timepoint for foveal development.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Pediatrics
Astrid Nieuwets, Mehmet N. Cizmeci, Floris Groenendaal, Lara M. Leijser, Corine Koopman, Manon J. N. L. Benders, Jeroen Dudink, Linda S. de Vries, Niek E. van der Aa
Summary: Background data on microstructural white matter integrity in preterm infants with post-hemorrhagic ventricular dilatation using diffusion tensor imaging are limited. This study found that extremely preterm infants with PHVD showed lower fractional anisotropy values in their corpus callosum compared with controls, and this impaired microstructure was associated with cognitive and motor scores at 2-years-corrected age.
PEDIATRIC RESEARCH
(2022)
Article
Critical Care Medicine
Namasivayam Ambalavanan, Debra E. Weese-Mayer, Anna Maria Hibbs, Nelson Claure, John L. Carroll, J. Randall Moorman, Eduardo Bancalari, Aaron Hamvas, Richard J. Martin, Juliann M. Di Fiore, Premananda Indic, James S. Kemp, Alaleh Dormishian, Katy N. Krahn, Jiaxing Qiu, Phyllis A. Dennery, Sarah J. Ratcliffe, James F. Troendle, Douglas E. Lake
Summary: Immature control of breathing in extremely preterm infants is associated with apnea, periodic breathing, intermittent hypoxemia, and bradycardia. Analyzing cardiorespiratory monitoring data can predict unfavorable respiratory outcomes at 40 weeks postmenstrual age and other outcomes such as bronchopulmonary dysplasia at 36 weeks postmenstrual age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medical Informatics
Xiaowan Wang, Chiara Trabatti, Lauren Weeke, Jeroen Dudink, Henriette Swanenburg de Veye, Rian M. J. C. Eijsermans, Corine Koopman-Esseboom, Manon J. N. L. Benders, Maria Luisa Tataranno
Summary: This study aims to investigate the predictive value of early postnatal aEEG-EEG features for neurodevelopmental outcomes in extremely preterm infants. The findings indicate that machine learning models can accurately predict intellectual impairments in infants at the age of 5-7.
LANCET DIGITAL HEALTH
(2023)
Article
Pediatrics
Margarita Thanhaeuser, David Steyrl, Renate Fuiko, Sophia Brandstaetter, Christoph Binder, Alexandra Thajer, Mercedes Huber-Dangl, Nadja Haiden, Angelika Berger, Andreas Repa
Summary: This study aimed to describe the neurodevelopmental outcome of extremely low birth weight (ELBW) infants with parenteral nutrition-associated cholestasis (PNAC) and found that ELBW infants with PNAC have delayed neurodevelopment and are at increased risk for adverse motor outcome.
Article
Endocrinology & Metabolism
Zhiwen Su, Lili Lin, Xi Fan, Chunhong Jia, Bijun Shi, Xiaoxia Huang, Jianwei Wei, Qiliang Cui, Fan Wu
Summary: This study used propensity score matching to reassess the clinical outcome of extremely premature infants (EPIs) based on sex. Male EPIs had a higher risk of respiratory complications than females, particularly at birth weight between 750 and 999 grams.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Cornelia Wiechers, Jan-Niklas Doll, Christoph Maas, Kerstin Grundler, Katja Buchner, Christian F. Poets, Axel R. Franz
Summary: In this study, rapid advancement of enteral feeds did not significantly impact infants' growth up to age 5. Weight and BMI standard deviation scores at age 5 remained lower than the reference population, suggesting that accelerated feeding may not contribute to increased childhood adiposity risk.
Article
Pediatrics
Pranav Jani, Umesh Mishra, Julia Buchmayer, Rajesh Maheshwari, Daphne D'Cruz, Karen Walker, Duygu Goezen, Krista Lowe, Audrey Wright, James Marceau, Mihaela Culcer, Archana Priyadarshi, Adrienne Kirby, James E. Moore, Ju Lee Oei, Vibhuti Shah, Umesh Vaidya, Abdelmoneim Khashana, Sunit Godambe, Fook Choe Cheah, Wen-Hao Zhou, Xiao-Jing Hu, Muneerah Satardien
Summary: This study examines skincare practices and skin injuries in extremely preterm infants. The findings reveal that diaper dermatitis and medical adhesive-related skin injuries are the most common. Following local skincare guidelines and regularly assessing the skin can reduce the occurrence of injuries. Consistency in practice and improved surveillance are crucial in minimizing skin injuries in preterm infants.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Hematology
Hanny Al-Samkari, Raj S. Kasthuri, Joseph G. Parambil, Hasan A. Albitar, Yahya A. Almodallal, Carolina Vazquez, Marcelo M. Serra, Sophie Dupuis-Girod, Craig B. Wilsen, Justin P. McWilliams, Evan H. Fountain, James R. Gossage, Clifford R. Weiss, Muhammad A. Latif, Assaf Issachar, Meir Mei-Zahav, Mary E. Meek, Miles Conrad, Josanna Rodriguez-Lopez, David J. Kuter, Vivek N. Iyer
Summary: Systemic bevacizumab was found to be safe and effective in managing chronic bleeding and anemia in HHT patients, leading to increased hemoglobin levels and reduced severity of nosebleeds. The number of red blood cell units transfused and iron infusions significantly decreased after treatment, with similar efficacy observed regardless of the underlying pathogenic mutation.
Article
Pediatrics
Einat Shmueli, Ori Goldberg, Meir Mei-Zahav, Patrick Stafler, Ophir Bar-On, Hagit Levine, Guy Steuer, Huda Mussaffi, Yulia Gendler, Hannah Blau, Dario Prais
Summary: Infants with chronic diseases hospitalized due to RSV bronchiolitis had longer hospitalizations and higher rates of transfer to the pediatric intensive care unit (PICU). Children with multiple comorbidities, especially those with Down's syndrome, are at particularly high risk for severe hospitalization.
PEDIATRIC PULMONOLOGY
(2021)
Article
Primary Health Care
Ophir Bar-On, Yulia Gendler, Patrick Stafler, Hagit Levine, Guy Steuer, Einat Shmueli, Dario Prais, Meir Mei-Zahav
Summary: A study found that wearing facemasks during brisk walks may lead to mild hypercarbia and desaturation, increasing feelings of difficulty breathing and shortness of breath. The clinical significance of these minor gas exchange abnormalities is unclear and warrants further investigation.
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
(2021)
Article
Immunology
Liat Ashkenazi-Hoffnung, Einat Shmueli, Shay Ehrlich, Adi Ziv, Ophir Bar-On, Einat Birk, Alexander Lowenthal, Dario Prais
Summary: This study on pediatric long COVID found that around 60% of children experienced symptoms associated with functional impairment 1-7 months after infection. A structured evaluation revealed mild abnormal findings in approximately half of the patients, mainly in the respiratory aspect.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Hagit Levine, Tommy Schonfeld, Shahar Handelsman, Ophir Bar-On, Guy Steuer, Meir Mei-Zahav, Dario Prais, Patrick Stafler
Summary: Diagnosis of recurrent or isolated tracheo-esophageal fistula (TEF) can be challenging and may be missed using ordinary flexible bronchoscopy and imaging studies. Low flow oxygen insufflation is a safe technique that may detect otherwise occult TEF.
RESPIRATORY MEDICINE
(2021)
Article
Pediatrics
Ori Goldberg, Nir Sokolover, Ruben Bromiker, Nofar Amitai, Gabriel Chodick, Oded Scheuerman, Haim Ben-Zvi, Gil Klinger
Summary: A decision tree model was developed to exclude the possibility of neonatal late-onset sepsis within 24 hours using blood tests and clinical indicators. The study found that infants with C-reactive protein levels exceeding 0.75 mg/dl, neutrophil-to-lymphocyte ratio over 1.5, and sick-appearance at 24 hours were all eventually diagnosed with sepsis. The decision tree model had an area under the receiver operating characteristic curve of 0.94, indicating its high accuracy in identifying sepsis cases.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Sari Goldstein Ferber, Aron Weller, Michal Ben-Shachar, Gil Klinger, Ronny Geva
Summary: This paper proposes a theory on the ontogenetic-neurobiological basis of self-regulation, suggesting that it is a complex mechanism starting from early brainstem development and progressing to cortical control. The paper discusses the synchronous reactivity between the sympathetic and parasympathetic systems, as well as the development of cardiovascular and white matter, in creating self-regulatory functions. It also proposes hypotheses for further investigation of the clock circuitry and its associations with other biological clocks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Galit Livnat, Adi Dagan, Moshe Heching, Einat Shmueli, Dario Prais, Karin Yaacoby-Bianu, Nili Stein, Meir Mei-Zahav, Michal Gur, Malena Cohen-Cymberknoh, Michal Shteinberg
Summary: This study demonstrates the clinical efficacy of ETI in patients with CF carrying non-F508del mutations, supporting its routine use in this patient group. ETI treatment resulted in reduced sweat chloride concentration, decreased pulmonary exacerbations, and improvements in nutritional status and lung function.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Pediatrics
Shay Ehrlich, Inbal Golan Tripto, Moran Lavie, Michal Cahal, Tommy Shonfeld, Dario Prais, Hagit Levine, Meir Mei-Zahav, Ophir Bar-On, Yulia Gendler, Jonatan Zalcman, Eahab Sarsur, Micha Aviram, Aviv Goldbart, Patrick Stafler
Summary: A retrospective study conducted in three pediatric centers in Israel showed that home high-flow nasal cannula (HFNC) therapy was well tolerated and safe for a variety of indications, leading to improved weight gain, reduced hospitalization days, and high parental satisfaction.
PEDIATRIC PULMONOLOGY
(2023)
Article
Medicine, General & Internal
Hagit Levine, Ophir Bar-On, Vered Nir, Nicole West, Yotam Dizitzer, Huda Mussaffi, Dario Prais
Summary: More than half of patients with primary ciliary dyskinesia (PCD) have reversible airway obstruction, which is not correlated with markers of atopy. Inhaled bronchodilators and corticosteroid therapies are commonly used for treating PCD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Einat Shmueli, Yulia Gendler, Patrick Stafler, Hagit Levine, Guy Steuer, Ophir Bar-On, Hannah Blau, Dario Prais, Meir Mei-Zahav
Summary: The study aims to evaluate if dynamic hyperinflation (DH) can predict pulmonary deterioration in cystic fibrosis (CF) patients and explore its association with peak VO2. The results showed a significant decline in lung function (FEV1%) trend in the DH group, and the DH group had a higher frequency of intravenous antibiotic treatment in the 4 years after CPETs. Peak VO2 was also correlated with lung function deterioration and intravenous antibiotic treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Einat Shmueli, Ophir Bar-On, Ben Amir, Meir Mei-Zahav, Patrick Stafler, Hagit Levine, Guy Steuer, Benjamin Rothschild, Lior Tsviban, Nofar Amitai, Miri Dotan, Gabriel Chodick, Dario Prais, Liat Ashkenazi-Hoffnung
Summary: This study examined pulmonary function tests in children with post-COVID-19 condition and found that the most common impairment was a mild obstructive pattern, with most patients having no history of asthma. Improvement was observed in long-term follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)