Review
Cardiac & Cardiovascular Systems
Blerina Asllanaj, Elizabeth Benge, Jieun Bae, Yi McWhorter
Summary: The management of sepsis in patients with pulmonary hypertension is challenging due to conflicting goals and complex hemodynamics. In sepsis without pulmonary hypertension, volume replacement followed by vasopressor therapy is the cornerstone of therapy. Individualized hemodynamic assessment and intravenous fluid resuscitation can improve the prognosis of critically ill patients. Specific challenges in patients with pulmonary hypertension include RV failure, gas exchange abnormalities, and managing fluid and diuretic use.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mitchel J. Colebank, M. Umar Qureshi, Sudarshan Rajagopal, Richard A. Krasuski, Mette S. Olufsen
Summary: This study presents a novel computational framework for predicting pulmonary hemodynamics in chronic thromboembolic pulmonary hypertension (CTEPH) and identifying optimal target lesions for balloon pulmonary angioplasty (BPA) therapy. The research uses a multiscale approach, incorporating simulated pulmonary artery pressure, wave intensity analysis, and a new quantitative metric of flow heterogeneity to personalize treatment for CTEPH patients who are not suitable for surgery.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
William R. Miranda, Patrick S. Kamath, C. Charles Jain, Heidi C. Connolly, Alexander C. Egbe
Summary: This study found that APRI and Fib-4 scores were positively correlated with resting and exercise Fontan pressure and PAWP, and negatively correlated with arterial O2 saturation. These results support the role of hepatic venous hypertension and reduced oxygen supply in patients with FALD.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Critical Care Medicine
Rui-Sheng Wang, Shi Huang, Stephen W. Waldo, Edward Hess, Madhura Gokhale, Shelsey W. Johnson, Katarina Zeder, Gaurav Choudhary, Jane A. Leopold, William M. Oldham, Gabor Kovacs, Matthew S. Freiberg, Ryan J. Tedford, Bradley A. Maron, Evan L. Brittain
Summary: This study aims to identify clinical markers and therapeutic targets that inform survival in patients with pulmonary hypertension (PH). The results suggest that elevated pulmonary arterial compliance (PAC) greater than 3.0 ml/mmHg is associated with improved survival, especially in patients with precapillary PH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ursula Reiter, Gabor Kovacs, Clemens Reiter, Corina Kraeuter, Volha Nizhnikava, Michael Fuchsjaeger, Horst Olschewski, Gert Reiter
Summary: MR 4D flow imaging allows for accurate non-invasive prediction and quantification of changes in mean pulmonary arterial pressure (mPAP) in adult patients with pulmonary hypertension (PH) or at risk of developing PH, with high accuracy and sensitivity.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenyu Sun, Hideki Ota, Haruka Sato, Saori Yamamoto, Shunsuke Tatebe, Tatsuo Aoki, Koichiro Sugimura, Junya Tominaga, Hiroaki Shimokawa, Takuya Ueda, Kei Takase
Summary: Systemic-pulmonary collaterals detected by intra-aortic CT angiography are associated with clinical severity and pulmonary perfusion defects in CTEPH.
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrea M. D. 'Armini, Maurizio Pin, Anna Celentano, Leslie J. Te Masiglat, Ermelinda Borrelli, Benedetta Vanini, Catherine Klersy, Giuseppe Silvaggio, Cristian Monterosso, Alessia Alloni, Carlo Pellegrini, Stefano Ghio
Summary: This study showed that in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy, a higher number of treated pulmonary artery branches is associated with better hemodynamic and clinical outcomes after surgery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Matthias Eberhard, Micheal McInnis, Marc de Perrot, Mona Lichtblau, Silvia Ulrich, Ilhan Inci, Isabelle Opitz, Thomas Frauenfelder
Summary: Dual-energy CT pulmonary angiography is highly sensitive in classifying the level of disease in patients with chronic thromboembolic pulmonary hypertension and is associated with hemodynamic improvement after surgery.
Review
Cardiac & Cardiovascular Systems
Jessica H. Huston, Sanjiv J. Shah
Summary: The development of pulmonary hypertension in patients with heart failure due to left heart disease is common and has adverse prognostic implications. However, there are currently no known specific treatments for this condition. Diagnostic criteria and clinical classification for pulmonary hypertension due to left heart disease are still evolving, posing challenges for researchers. The pathobiology of this condition is not well understood, but factors such as increased wall stress and endothelial dysfunction are believed to contribute to pulmonary vascular remodeling. Further investigation is needed to better understand the drivers of this condition and develop effective prevention and treatment strategies.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Gaurav Gulati, E. Wilson Grandin, David DeNofrio, Jenica N. Upshaw, Amanda R. Vest, Michael S. Kiernan
Summary: The postoperative hemodynamic status of LVAD patients is associated with early RHF, mortality, and GIB, but not with stroke risk.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Eva Rumiz, Andres Cubillos, Juan Vicente Vilar, Pilar Garcia, Alberto Berenguer, Lorenzo Facila, Ernesto Valero, Veronica Vidal, Salvador Morell, Julio Nunez
Summary: The non-invasive estimation of pulmonary vascular resistance using CMR shows poor accuracy and limited capacity to discriminate increased PVR values in patients with acute heart failure.
SCIENTIFIC REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
S. P. Wright, T. G. Dawkins, N. D. Eves, R. Shave, R. J. Tedford, S. Mak
Summary: The paragraph discusses the hemodynamic function of the integrated RV-PV-LA unit during exercise, focusing on the complex interactions and responses of the pulmonary circulation. Recent studies have provided insights into the mechanisms that modify the PV pressure-flow relationship in healthy adults during exercise, highlighting the impact of age-related remodeling and sex-related cardiopulmonary differences on these responses.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Respiratory System
Dieuwertje Ruigrok, M. Louis Handoko, Lilian J. Meijboom, Esther J. Nossent, Anco Boonstra, Natalia J. Braams, Jessie van Wezenbeek, Robert Tepaske, Pieter Roel Tuinman, Leo M. A. Heunks, Anton Vonk Noordegraaf, Frances S. de Man, Petr Symersky, Harm-Jan Bogaard
Summary: Residual chronic thromboembolic pulmonary hypertension (CTEPH) can be excluded after pulmonary endarterectomy (PEA) by using early post-operative haemodynamics, N-terminal pro-brain natriuretic peptide (NT-proBNP), cardiopulmonary exercise testing (CPET) and transthoracic echocardiography (TTE) 6 months after PEA, reducing the need for re-right heart catheterisation (RHC).
Article
Cardiac & Cardiovascular Systems
Emmanuelle Born, Larissa Lipskaia, Marielle Breau, Amal Houssaini, Delphine Beaulieu, Elisabeth Marcos, Remi Pierre, Marcio Do Cruzeiro, Marine Lefevre, Genevieve Derumeaux, Dmitry V. Bulavin, Marion Delcroix, Rozenn Quarck, Virinder Reen, Jesus Gil, David Bernard, Jean-Michel Flaman, Serge Adnot, Shariq Abid
Summary: This study investigated the role of senescent cells in patients with pulmonary arterial hypertension and animal models. The findings revealed that clearance of senescent cells resulted in vascular remodeling and damage to the pulmonary artery.
Editorial Material
Medicine, General & Internal
David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Nathan Messas, Michele Giovinazzo, John D. Catravas
Summary: Exercise-induced increases in pulmonary blood flow can further raise pulmonary arterial pressure in patients with pulmonary arterial hypertension, due to a reduced recruitment of pulmonary capillaries. Current therapies for this condition have limited effect in lowering pulmonary arterial pressure and restoring capillary recruitment. Novel therapies with antiproliferative properties are being developed to address cellular obstruction in the arterioles and restore capillary recruitment, resulting in lower pulmonary arterial pressure during exercise testing.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
S. Renet, M. -C. Chaumais, M. Gallant-Dewavrin, E. Jouet, Y. Bezie, M. Humbert, A. Rieutord, O. Las Vergnas
Summary: This study aimed to explore the role of pharmacists in patient education and counseling, describing the perception of knowledge exchange (KE) between asthma/pulmonary arterial hypertension patients and pharmacists (hospital/community) based on the 4C typology: cure (C1), care (C2), coordination/supply chain (C3), and characteristics of the pathophysiology/disease mechanisms (C4). The results showed that KE was correlated with pathology, disease severity, disease duration, age, and hospital/community pharmacist. Patients expected pharmacists to provide care and coordination/supply chain services. The 4C typology provides a holistic framework for optimizing the pharmacists' role in education and counseling of patients with chronic diseases.
ANNALES PHARMACEUTIQUES FRANCAISES
(2023)
Review
Critical Care Medicine
Bartolome R. Celli, Leonardo M. Fabbri, Shawn D. Aaron, Alvar Agusti, Robert D. Brook, Gerard J. Criner, Frits M. E. Franssen, Marc Humbert, John R. Hurst, Maria Montes de Oca, Leonardo Pantoni, Alberto Papi, Roberto Rodriguez-Roisin, Sanjay Sethi, Daiana Stolz, Antoni Torres, Claus F. Vogelmeier, Jadwiga A. Wedzicha
Summary: Patients with chronic obstructive pulmonary disease (COPD) may experience acute episodes of worsening dyspnea, accompanied by increased cough, sputum, and/or sputum purulence. These exacerbations impact health status, accelerate lung function decline, and increase the risk of hospitalization. It is important to recognize and address other morbidities that can mimic or aggravate COPD exacerbations to improve outcomes and reduce readmissions.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Rheumatology
Sebastien Sanges, Lisa Rice, Ly Tu, Eleanor Valenzi, Jean-Luc Cracowski, David Montani, Julio C. Mantero, Camille Ternynck, Guillemette Marot, Andreea M. Bujor, Eric Hachulla, David Launay, Marc Humbert, Christophe Guignabert, Robert Lafyatis
Summary: This study examined the serum proteome of patients with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) and identified two proteins that were significantly correlated with pulmonary vascular resistance (PVR), potentially providing biomarkers for earlier diagnosis and treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
D. Montani, E-M Jutant, G. Simonneau, M. Humbert
Summary: The 2022 guidelines from the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) propose a new definition of pulmonary hypertension (PH) based on hemodynamics, lowering the threshold of mean pulmonary arterial pressure (mPAP) to 20 mmHg. They also introduce a new clinical classification of PH, integrating new data from the literature and dividing it into five groups based on distinct mechanisms.
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2023)
Letter
Medicine, General & Internal
M. Humbert
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2023)
Review
Respiratory System
J. Le Pavec, L. Savale, G. Prevot, D. Montani, O. Sitbon, E. Fadel, M. Humbert, O. Mercier
REVUE DES MALADIES RESPIRATOIRES
(2023)
Article
Rheumatology
Benjamin Chaigne, Kevin Chevalier, Athenais Boucly, Christian Agard, Antoine Baudet, Arnaud Bourdin, Celine Chabanne, Vincent Cottin, Pierre Fesler, Francois Goupil, Patrick Jego, David Launay, Herve Levesque, Arnaud Maurac, Shirine Mohamed, Cecile Tromeur, Laurence Rottat, Olivier Sitbon, Marc Humbert, Luc Mouthon
Summary: Objective of this study was to describe PAH in well-characterized MCTD patients. Results showed that pericarditis, polyarthritis, thrombocytopenia, ILD and anti-Sm antibodies were independent predictive factors of PAH in MCTD. Survival rates of MCTD-PAH patients did not differ from SLE-PAH and SSc-PAH patients. Tobacco exposure was an independent predictor of mortality in MCTD-PAH.
Article
Medicine, Research & Experimental
Frederic Perros, Etienne-Marie Jutant, Laurent Savale, Peter Dorfmueller, Marc Humbert, David Montani
Summary: Pulmonary arterial hypertension (PAH) is a rare disease that mainly affects the pre-capillary pulmonary vascular bed, but some forms of the disease involve venous/capillary involvement. It is characterized by obstructive remodeling of the pulmonary arterioles, vascular pruning, increased right ventricular afterload, and right heart failure. Current treatments focus on targeting endothelial dysfunction and vasodilation, while new treatments aiming at pulmonary artery remodeling are being developed.
M S-MEDECINE SCIENCES
(2023)
Article
Cell Biology
Matthieu Leuillier, Valentin Platel, Ly Tu, Guillaume Feugray, Raphael Thuillet, Deborah Groussard, Hind Messaoudi, Mina Ottaviani, Mustapha Chelgham, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Christophe Morisseau, Valery Brunel, Thomas Duflot, Christophe Guignabert, Jeremy Bellien
Summary: Inhibitors of soluble epoxide hydrolase (sEH) present an opportunity for developing oral drugs for cardiovascular and inflammatory diseases. However, the administration of sEH inhibitors may lead to the development of pulmonary hypertension (PH). This study evaluated the impact of chronic oral administration of the sEH inhibitor TPPU on hemodynamics and pulmonary vascular remodeling in rats. The results showed that TPPU did not induce or aggravate PH and RV dysfunction, and may have a potential beneficial effect against pulmonary artery remodeling in humans.
Editorial Material
Respiratory System
Marlies Wijsenbeek, Marc Humbert, Thomas Wagner, Michael Kreuter
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Respiratory System
Jerome Le Pavec, Christophe Pison, Sandrine Hirschi, Vincent Bunel, Pierre Mordant, Olivier Brugiere, Morgan Le Guen, Anne Olland, Benjamin Coiffard, Benjamin Renaud-Picard, Adrien Tissot, Geoffrey Brioude, Raphael Borie, Bruno Crestani, Gaetan Deslee, Sandrine Stelianides, Herve Mal, Armelle Schuller, Loic Falque, Gwenaelle Lorillon, Abdellatif Tazi, Pierre Regis Burgel, Dominique Grenet, Sandra De Miranda, Anne Bergeron, David Launay, Vincent Cottin, Hilario Nunes, Dominique Valeyre, Yurdagul Uzunhan, Gregoire Prevot, Olivier Sitbon, David Montani, Laurent Savale, Marc Humbert, Elie Fadel, Olaf Mercier, Jean Francois Mornex, Gaelle Dauriat, Martine Reynaud-Gaubert
Summary: Lung transplantation is a rapidly evolving field that has made significant advancements in improving donor and recipient selection, addressing surgical challenges, perioperative care, and long-term complications. To assist pulmonologists in managing end-stage respiratory insufficiency, determining eligibility for lung transplantation, and referring patients to transplant centers, the Francophone Pulmonology Society has established a task force to develop comprehensive guidelines based on the latest literature and evaluation of risk factors for patient survival after transplantation.
RESPIRATORY MEDICINE AND RESEARCH
(2023)
Article
Respiratory System
Antoine Beurnier, Laurent Savale, Xavier Jais, Romain Colle, Tai Pham, Luc Morin, Sophie Bulifon, Nicolas Noel, Athenais Boucly, Benoit Delbarre, Nathan Ebstein, Samy Figueiredo, Matthieu Gasnier, Anatole Harrois, Etienne-Marie Jutant, Mitja Jevnikar, Sophia Keddache, Anne-Lise Lecoq, Olivier Meyrignac, Florence Parent, Jeremie Pichon, Mariana Preda, Anne Roche, Andrei Seferian, Marie-France Bellin, Thomas Gille, Emmanuelle Corruble, Olivier Sitbon, Laurent Becquemont, Xavier Monnet, Marc Humbert, David Montani
Summary: This study found that functional respiratory complaints are common in post-COVID-19 individuals, especially among those with unexplained dyspnoea. These complaints are associated with the severity of dyspnoea, quality of life, and psychological symptoms.
Letter
Critical Care Medicine
David Montani, Jason Weatherald, Marc Humbert, Olivier Sitbon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Correction
Cardiac & Cardiovascular Systems
[Anonymous]
EUROPEAN HEART JOURNAL
(2023)
Correction
Cardiac & Cardiovascular Systems
Bradley M. Maron, Marc Humbert
EUROPEAN HEART JOURNAL
(2023)