Review
Cell Biology
Eleonora Russo, Giulio Russo, Mauro Cassese, Maurizio Braccio, Massimo Carella, Paolo Compagnucci, Antonio Dello Russo, Michela Casella
Summary: Functional mitral regurgitation (FMR) is caused by alterations in the left ventricle and left atrium geometry, resulting in an imbalance between closing and tethering forces. FMR affects quality of life and increases mortality, and there is no clear treatment approach. Left ventricle dyssynchrony may contribute to the onset and worsening of FMR, and is an important target for treatment.
Review
Cardiac & Cardiovascular Systems
Matthew F. Yuyun, Jacob Joseph, Sebhat A. Erqou, Scott Kinlay, Justin B. Echouffo-Tcheugui, Adelqui O. Peralta, Peter S. Hoffmeister, William E. Boden, Hirad Yarmohammadi, David T. Martin, Jagmeet P. Singh
Summary: Cardiac resynchronization therapy significantly reduces secondary mitral regurgitation in patients with severe left ventricular systolic dysfunction. Lack of improvement in secondary MR post-CRT is associated with significantly elevated risk of all-cause mortality and possibly cardiovascular mortality and heart failure hospitalization.
HEART FAILURE REVIEWS
(2023)
Article
Medicine, General & Internal
Muhammed Gercek, Olaf Oldenburg, Mustafa Gercek, Henrik Fox, Volker Rudolph, Thomas Puehler, Hazem Omran, Lisa Katharina Wolf, Kavous Hakim-Meibodi, Andreas M. Zeiher, Jan Gummert, Zisis Dimitriadis
Summary: The study found a high prevalence of SDB in patients with severe primary mitral regurgitation, which may lead to postoperative complications and prolonged intensive care. Three months after mitral valve surgery, there was a significant reduction in the prevalence of SDB, but it remains high, highlighting the bidirectional relationship between SDB and heart failure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Xavier Galloo, Kensuke Hirasawa, Pieter van der Bijl, Martin B. Leon, Nina Ajmone Marsan, Jeroen J. Bax
Summary: In patients with heart failure and functional mitral regurgitation, reducing the severity of mitral regurgitation through cardiac resynchronization therapy can lead to improved left atrial function and lower all-cause mortality.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Aniek L. van Wijngaarden, Valentina Mantegazza, Yasmine L. Hiemstra, Valentina Volpato, Pieter van der Bijl, Mauro Pepi, Meindert Palmen, Victoria Delgado, Nina Ajmone Marsan, Gloria Tamborini, Jeroen J. Bax
Summary: This study aimed to evaluate the prognostic impact of extra-mitral valve cardiac involvement in patients with severe primary MR and proposed a new classification system to help refine risk stratification and timing of surgery.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Sung-Han Yoon, Moody Makar, Saibal Kar, Tarun Chakravarty, Luke Oakley, Navjot Sekhon, Keita Koseki, Mamoo Nakamura, Michele Hamilton, Jignesh K. Patel, Siddharth Singh, Sabah Skaf, Robert J. Siegel, Jeroen J. Bax, Raj R. Makkar
Summary: This study evaluated the clinical outcomes of transcatheter edge-to-edge repair (TEER) in patients with mitral regurgitation (MR) of different etiology and left ventricular and left atrial remodeling. The results showed that despite favorable procedural outcomes, patients with atrial FMR and ventricular FMR had worse clinical outcomes compared to those with degenerative MR.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas P. P. Craven, Pei G. G. Chew, Laura E. E. Dobson, Miroslawa Gorecka, Martine Parent, Louise A. E. Brown, Christopher E. D. Saunderson, Arka Das, Amrit Chowdhary, Nicholas Jex, David M. M. Higgins, Erica Dall'Armellina, Eylem Levelt, Dominik Schlosshan, Peter P. P. Swoboda, Sven Plein, John P. P. Greenwood
Summary: By using serial CMR, we investigated cardiac reverse remodeling and residual MR post-MVr vs MVR with chordal preservation in patients with primary MR. The results showed that MVR with chordal preservation may offer comparable cardiac reverse remodeling and functional benefits at 6-months compared to MVr.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Blazej Michalski, Ivan Stankovic, Efstathios Pagourelias, Agnieszka Ciarka, Marit Aarones, Stefan Winter, Lothar Faber, Svend Aakhus, Wolfgang Fehske, Marta Cvijic, Jens-Uwe Voigt
Summary: This study aimed to explore the association between mechanical dyssynchrony of the left ventricle before CRT and improvement of MR after CRT. The results showed that ApRock, SF, and baseline MR were strongly associated with MR reduction after CRT, with LV reverse remodeling being its underlying mechanism.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Tomas Benito-Gonzalez, Fernando Carrasco-Chinchilla, Rodrigo Estevez-Loureiro, Isaac Pascual, Dabit Arzamendi, Carmen Garrote-Coloma, Luis Nombela-Franco, Manuel Pan, Ana Serrador, Xavier Freixa, Ana Belen Cid Alvarez, Rosa Ana Hernandez Antolin, Leire Andraka, Ignacio Cruz-Gonzalez, Jose Ramon Lopez-Minguez, Jose Luis Diez Gil, Cristobal Urbano-Carrillo, Dario Sanmiguel Cervera, Juan Sanchis, Francisco Bosa, Valeriano Ruiz, Eduardo Molina, Victor Manuel Becerra-Munoz, Javier Gualis, Pablo Avanzas, Chi Hion Li, Jose Antonio Baz, Pilar Jimenez-Quevedo, Dolores Mesa, Ignacio J. Amat-Santos, Ander Regueiro, Ramiro Trillo, Antonio Jesus Dominguez Franco, Juan Horacio Alonso-Briales, Felipe Fernandez-Vazquez
Summary: After TMVR with MitraClip treatment for AFMR patients, there was a significant reduction in the severity of AFMR, which persisted at 12 months. AFMR patients showed a significant improvement in heart function post operation, and had lower rates of readmission and mortality within the first year.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tais De Jesus, Mahmoud M. Alashry, Ratnasari Padang, Sorin Pislaru, Vuyisile T. Nkomo, Patricia A. Pellikka, Cristina Pislaru
Summary: Non-invasive measurements of myocardial stiffness can predict functional deterioration after mitral valve repair for chronic primary mitral regurgitation. Higher intrinsic velocity propagation (iVP) independently predicted a larger drop in left ventricular ejection fraction post-intervention in patients undergoing mitral valve repair.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Medicine, General & Internal
Ayham Daher, Tobias Mueller, Nikolaus Marx, Joerg Schroder, Mohammad Almalla, Andras P. Keszei, Sebastian Reith, Michael Dreher
Summary: The prevalence of sleep disordered breathing is high among patients with mitral regurgitation, even in those without daytime sleepiness. Patients with SDB had significant improvements in respiratory parameters after MitraClip placement, but no significant changes in sleepiness scores were observed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Xavier Galloo, Kensuke Hirasawa, Nina Ajmone Marsan, Pieter van der Bijl, Victoria Delgado, Jeroen J. Bax
Summary: The study showed that cardiac resynchronization therapy (CRT) can improve significant tricuspid regurgitation (TR) in a substantial proportion of patients with heart failure (HF), leading to better long-term outcomes.
Article
Medicine, General & Internal
Martin J. Volz, Sven T. Pleger, Andreas Weber, Nicolas A. Geis, Sonja Hamed, Derliz Mereles, Ute Hegenbart, Hugo A. Katus, Norbert Frey, Philip W. Raake, Michael M. Kreusser
Summary: This study retrospectively analyzed five patients with cardiac amyloidosis undergoing PMVR, showing that the procedure is safe and feasible in this patient group and may carry a possible survival benefit. Further research is needed to confirm these findings.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Veterinary Sciences
Pakit Boonpala, Nakkawee Saengklub, Sirinapa Srikam, Wilawan Ji-au, Yaowalak Panyasing, Sarawut Kumphune, Anusak Kijtawornrat
Summary: This study investigated the effects of pimobendan on cardiac function and ultrastructure in a rat model of chronic MR. The results demonstrated that pimobendan preserved cardiac function and structure, improved mitochondrial quality, and acted as an ROS scavenger. These findings suggest that pimobendan may be a potential therapeutic agent for MR.
BMC VETERINARY RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Nguyen, Steven E. Williams, Gillian Falkner, Anoop K. Shetty
Summary: The ARTO device is a percutaneous device for functional mitral regurgitation that reduces the minor axis of the mitral valve. In this study, the technical feasibility of an LV lead implant in patients with an ARTO device in place was demonstrated.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)