Article
Biophysics
Marcos E. Peralta, Julieta C. Parisi, Daniel C. Castrogiovanni, Sushilkumar A. Jadhav, Luciano Carlos, Gabriela N. Bosio, Daniel O. Martire
Summary: Stimuli-responsive nanocarriers have significant applications in the development of new strategies for disease diagnosis and treatment. This study demonstrates the controlled drug delivery using magnetite nanoparticles coated with mesoporous silica and grafted with a thermoresponsive polymer. The efficient drug release and the cytoprotective effect of a specific drug were evaluated using various cell models, providing potential applications for this drug delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Noemie Penoy, Bruno Grignard, Brigitte Evrard, Geraldine Piel
Summary: Liposomes were produced using an innovative method with supercritical carbon dioxide as a dispersing agent, following a quality by design strategy to find optimal production conditions. The study showed that the new method provided liposomes with physicochemical characteristics similar to those obtained by conventional methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Oncology
Dieter Haemmerich, Krishna K. Ramajayam, Danforth A. Newton
Summary: Various nanoparticles, such as thermosensitive liposomes (TSL), have been developed for targeted drug delivery to cancerous tumors by releasing the drug in response to hyperthermia. TSL can achieve superior tumor drug uptake compared to traditional drug delivery systems. This review discusses the delivery kinetics of TSL and provides guidelines on how to improve drug delivery by optimizing the combination of TSL, drug, and hyperthermia method.
Article
Materials Science, Biomaterials
Shuying Li, Yanjuan Wu, Siyuan Liu, Ting Wu, Guozheng Liu, Tianduo Li, Zhaowei Chen
Summary: This work developed an innovative nanoplatform based on a Pt(iv) prodrug and a near-infrared photosensitizer, which can achieve multifunctional cancer therapy and diagnosis. The nanoplatform allows real-time tracking of nanodrugs and has dual effects of photothermal therapy and chemotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Yun Tan, Yao Liu, Yujing Liu, Rui Ma, Jingshan Luo, Huijie Hong, Xiaojia Chen, Shengpeng Wang, Chuntai Liu, Yi Zhang, Tongkai Chen
Summary: The research developed a drug delivery platform hydrogel (MAG-NCs@Gel) to improve drug solubility, nasal cavity residence time, and brain targeting efficiency. Continuous intranasal delivery enabled the drug to cross the BBB and enter dopaminergic neurons, effectively alleviating Parkinson's disease symptoms.
Review
Chemistry, Multidisciplinary
Jonas Kaltbeitzel, Peter R. Wich
Summary: Proteins and enzymes are versatile biomaterials with high specificity, degradability, low toxicity, and good biocompatibility, making them ideal for various medical applications. Protein nanoparticles, formed by arranging native or modified proteins into nanometer-sized assemblies, have emerged as a promising nanosystem for drug delivery, imaging, nanocatalysis, and protein therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Materials Science, Multidisciplinary
Josiel Martins Costa, Ambrosio Florencio de Almeida Neto
Summary: The impregnation of substances using supercritical CO2 technology has shown promise in developing high-tech products, particularly in producing novel catalysts. This approach allows the production of unique nanoparticles with varied morphologies, beneficial for use in energy storage systems.
Article
Pharmacology & Pharmacy
Yu-Jen Lu, Hao-Lung Hsu, Yu-Hsiang Lan, Jyh-Ping Chen
Summary: Thermosensitive cationic magnetic liposomes (TCMLs) were prepared for controlled drug/gene release in cancer treatment. The liposomes were made from DPPC, cholesterol, PEGylated lipid, and DDAB, and co-entrapped MNPs and CPT-11. The drug release was triggered by temperature increase or magneto-heating, and the liposomes showed enhanced cytotoxicity and gene silencing effect in glioblastoma cells.
Article
Polymer Science
Michele Dai, Guillaume Goudounet, Hang Zhao, Bertrand Garbay, Elisabeth Garanger, Gilles Pecastaings, Xavier Schultze, Sebastien Lecommandoux
Summary: The study discusses the synthesis of a well-defined hybrid ABC triblock terpolymer and the formation of different micellar and gel structures under various conditions, showing potential applications in biomedical fields.
Article
Chemistry, Physical
Paolo Trucillo, Ernesto Reverchon
Summary: By utilizing PEG for liposomes coating and a supercritical assisted process, stable liposomes with sizes ranging from 134 to 166nm were successfully produced. PEG-coated liposomes exhibited controlled drug release, with release time at least three times longer than standard liposomes.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Chemistry, Multidisciplinary
Wael Hamd, Digambara Patra, Houssam El-Rassy
Summary: The study demonstrates for the first time the loading of curcumin into different metal oxide aerogels, showing enhanced bioavailability and stability for potential therapeutic applications. Additionally, the study uncovers distinct behaviors of curcumin-metal oxide interactions, shedding light on the mechanisms underlying such complexation processes.
Article
Chemistry, Multidisciplinary
Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang, Zhen Liu
Summary: This study presents a smart prodrug delivery system based on molecularly imprinted polymers (MIPs) for specific accumulation and gradual release of drugs at tumor sites. In contrast to traditional prodrug designs, this system is liver-independent and relies on tumor environments for drug release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Pharmacology & Pharmacy
Randall A. Meyer, G. Patrick Hussmann, Norman C. Peterson, Jose Luis Santos, Anthony D. Tuesca
Summary: LPH nanocarriers show great potential as vehicles for mRNA delivery and expression in tissues, with the composition of LPH and route of administration influencing tissue expression and longevity of protein expression.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
Pier Francesco Ferrari, Paolo Trucillo, Giulia De Negri Atanasio, Chiara Bufalini, Roberta Campardelli, Patrizia Perego, Domenico Palombo, Ernesto Reverchon
Summary: Encapsulation of antibodies within liposomes using supercritical fluid-based process called SuperLip was studied. The process enables continuous production of high encapsulation efficiency liposomes with mean diameters ranging between 205 and 501 nm. The effect of operative parameters on liposome properties and antibody entrapment efficiency was investigated.
Review
Chemistry, Multidisciplinary
Yun Liu, Guangze Yang, Yue Hui, Supun Ranaweera, Chun-Xia Zhao
Summary: Nanoparticles (NPs) have gained significant interest in drug delivery, and microfluidics shows promise in their precise control and manufacturing. The successful use of microfluidic NPs in mRNA vaccines represents a major milestone and demonstrates the feasibility of industrial-scale production. This article provides a critical review of recent progress in microfluidic NPs for drug delivery, including the synthesis of organic and inorganic NPs, and their various applications.
Article
Multidisciplinary Sciences
T. Voisin, A. Erriguible, C. Aymonier
Article
Chemistry, Multidisciplinary
Nathalie Daro, Tony Vaudel, Luc Afindouli, Samuel Marre, Cyril Aymonier, Guillaume Chastanet
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Physical
Aimery Auxemerya, Brigitte Botello Frias, Ekaterina Smal, Katarzyna Dziadek, Gilles Philippot, Piotr Legutko, Michail Simonov, Sebastien Thomas, Andrzej Adamski, Vladislav Sadykov, Ksenia Parkhomenko, Anne-Cecile Roger, Cyril Aymonier
JOURNAL OF SUPERCRITICAL FLUIDS
(2020)
Article
Chemistry, Physical
Nikolay Gromov, Oxana P. Taran, Cyril Aymonier, Valentin N. Parmon
REACTION KINETICS MECHANISMS AND CATALYSIS
(2020)
Article
Engineering, Environmental
T. Jaouhari, F. Zhang, T. Tassaing, S. Fery-Forgues, C. Aymonier, S. Marre, A. Erriguible
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Maria Letizia De Marco, Taizhi Jiang, Jie Fang, Sabrina Lacomme, Yuebing Zheng, Alexandre Baron, Brian A. Korgel, Philippe Barois, Glenna L. Drisko, Cyril Aymonier
Summary: This study demonstrates the synthesis of Mie-resonant core-shell particles with overlapping electric and magnetic dipole resonances in the visible spectrum, allowing for tuning of the relative position and intensity of these resonances. Coating high-index particles with low-index shells coalesces the dipoles while maintaining high scattering efficiency, leading to broadband forward scattering. This synthetic strategy opens up new possibilities for metamaterial fabrication with unprecedented control over visible light manipulation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Forestry
Cyril Aymonier, Nikolay V. Gromov, Oxana P. Taran, Valentin N. Parmon
Summary: This study demonstrates the possibility of producing glucose and 5-HMF from inedible cellulose using solid acid catalysts based on Sibunit carbon material; the acidity of the catalyst and the nature and amount of surface acid groups affect the formation of glucose and 5-HMF; through proper processing, yields of up to 75% and 10% for glucose and 5-HMF, respectively, can be obtained from polysaccharides.
WOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Valentina Musumeci, Guido Goracci, Paula Sanz Camacho, Jorge S. Dolado, Cyril Aymonier
Summary: The dynamics of water molecules in calcium silicate hydrates are significantly influenced by the local chemical environment, affecting the distribution of hydrogen bond network. In SiOH-rich environments, the ordered ice-like solvation water transforms into a disordered liquid-like distribution in CaOH-rich environments.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Editorial Material
Chemistry, Multidisciplinary
Valentina Musumeci, Guido Goracci, Paula Sanz Camacho, Jorge S. Dolado, Cyril Aymonier
Summary: By synthesizing model nanocrystals and studying them with spectroscopic techniques, this research reveals that the local chemical environment has a significant impact on the hydrogen bond network and dynamics of solvent water. Solvation water in SiOH-rich environments shows an ordered ice-like state, while in CaOH-rich environments, it exhibits a disordered liquid-like distribution.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
B. Giroire, A. Garcia, S. Marre, T. Cardinal, C. Aymonier
Summary: A chemistry platform for the continuous synthesis of high-quality III-nitride quantum dots using supercritical solvents and short residence times was demonstrated. The GaN quantum dots produced exhibited strong UV photoluminescence and showed a continuous bandgap shift towards lower energies with increasing indium content. Additionally, an example of metal site substitution in the synthesis of InxGa1-xN solid solution was provided.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Nicolas Biscay, Lucile Henry, Tadafumi Adschiri, Masahiro Yoshimura, Cyril Aymonier
Summary: Silicon carbide materials are excellent candidates for high-performance applications due to their outstanding thermomechanical properties and corrosion resistance. The oxidation behavior of SiC depends on temperature and time, and wet oxidation can accelerate the process. Hydrothermal media have an impact on SiC materials, which has been explained by different models.
Article
Chemistry, Physical
Qi Ming She, Jia Hui Liu, Cyril Aymonier, Chun Hui Zhou
Summary: A facile method for in situ fabrication of LDH film immobilizing gold nanoparticles in a capillary microreactor is reported in this study, showing good catalytic performance in glycerol carbonylation with urea. Adjusting the reaction conditions allows precise control of film thickness, morphology, and Au loading, demonstrating high stability and productivity in heterogeneous catalysis.
MOLECULAR CATALYSIS
(2021)
Article
Biochemical Research Methods
Gustavo Ochoa-Vazquez, Boris Kharisov, Ana Arizmendi-Morquecho, Anais Cario, Cyril Aymonier, Samuel Marre, Israel Lopez
Summary: A simple and low-cost continuous segmented-flow process for the synthesis of Ag and Au spherical-shaped nanoparticles is presented. The flow conditions have opposite effects on the synthesis of Ag and Au nanoparticles, with low residence times improving Ag nanoparticle production and high residence times improving Au nanoparticle synthesis yield and quality.
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2022)
Article
Chemistry, Physical
Anais Cario, Guillaume Aubert, Jean-Pierre Alcaraz, Jean-Pascal Borra, Nicolas Jidenko, Mathieu Barrault, Soleiman Bourrous, Victor Mocho, Francois Xavier Ouf, Samuel Marre, Philippe Cinquin, Cyril Aymonier
Summary: The study demonstrates that Supercritical Carbon Dioxide treatment meets the mandatory requirements for safe reuse of FFP2 respirators, effectively decontaminating spores and preserving filtration efficiency. This method is simple, cost-effective, and aligns with economic and sustainable development goals.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Chemistry, Physical
Dolores Bourbiaux, Yu Xu, Laurence Burel, Firat Goc, Pascal Fongarland, Regis Philippe, Guillaume Aubert, Cyril Aymonier, Franck Rataboul, Laurent Djakovitch
Summary: Lignin is a major component of lignocellulosic biomass and can be depolymerized under mild oxidizing conditions with the Pd catalyst to produce oxygenated aromatic compounds. The richness of functional groups in lignin makes it an attractive precursor for a wide variety of aromatic compounds. Differences in selectivity in aromatic monomers may arise depending on the catalyst nature and synthetic methods used.
