Article
Environmental Sciences
David A. Geier, Mark R. Geier
Summary: A study using NHANES data found that 82% of the tested individuals in the United States had detectable concentrations of glyphosate in their urine. There was a significant inverse correlation between glyphosate concentrations and total testosterone and total estradiol concentrations, but no correlation with sex hormone binding globulin concentrations.
Article
Chemistry, Applied
Yangyu Yang, Xia Tong, Yuxia Chen, Rongrong Zhou, Guihan Cai, Tongtao Wang, Shuihan Zhang, Shuyun Shi, Ying Guo
Summary: A dual-emission carbon dots-based nonenzymatic fluorescent sensing platform has been developed for simultaneous and high-performance detection of parathion-methyl and glyphosate. The carbon dots with emissions at 440 nm and 660 nm were prepared from mulberry leaves and sodium hydroxide. The sensing platform showed excellent sensitivity and selectivity, and could be applied in food/herbal samples with acceptable recoveries and high selectivity. Moreover, an OR logic gate was achieved for estimating food, herbal, or environmental safety.
Article
Environmental Sciences
Maxime Gauthier, Jeremy Defrance, Catherine Jumarie, Emmanuelle Vulliet, Jeanne Garric, Monique Boily, Olivier Geffard
Summary: In the past decade, Gammarus fossarum has been proven to be a reliable species for biomonitoring programs to evaluate the impact of environmental contamination on non-target organisms. A study was conducted to explore the functions of retinoid metabolism in this crustacean model and investigate the effects of different substances on reproduction and development. The results demonstrated the involvement of retinoic acid in oogenesis and molting, and suggested its potential role in mediating the effects of certain substances. This study contributes to understanding the reproductive and developmental control in Gammarus fossarum and provides insights for further research on the impact of xenobiotics on the retinoid system in this species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Marlise Guerrero Schimpf, Maria M. Milesi, Maria Victoria Zanardi, Jorgelina Varayoud
Summary: The study found that neonatal exposure to glyphosate-based herbicides altered gene expression and induced DNA hypermethylation in the uterine tissue of early life, which disrupted hormone balance and estrous cyclicity. Young adult females exposed to GBH showed elevated estradiol and decreased progesterone levels, leading to changes in their reproductive cycle. Aged females exposed to GBH developed leiomyoma and pre-neoplastic glandular lesions in the uterus, as well as vaginal rhabdomyosarcoma and intrahepatic bile duct adenoma.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Jeane Maria Oliveira, Jamilli Zenzeluk, Paula Bargi-Souza, Raphael Escorsim Szawka, Marco Aurelio Romano, Renata Marino Romano
Summary: The increased use of glyphosate-based herbicides raises concerns about their impact on the environment and human health. This study investigates the potential effects of low levels of GBH exposure on the hypothalamic-pituitary-thyroid (HPT) axis function in male Wistar rats at different life stages. The results show that GBH exposure alters the transcriptional regulation of HPT axis genes and induces changes in the morphometric parameters of the thyroid gland, with potential implications for thyroid hormone production and function in target organs.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Anita A. Thambirajah, Michael G. Wade, Jonathan Verreault, Nicolas Buisine, Veronica A. Alves, Valerie S. Langlois, Caren C. Helbing
Summary: This critical review highlights the complexity of Endocrine Disrupting Chemicals interfering with Thyroid Hormone function through interactions with other hormonal axes, and emphasizes the lack of data generated in non-mammalian vertebrate classes. With the availability of more genomics-based resources, better identification and delineation of EDC effects, modes of action, and identification of effective biomarkers suitable for HPT disruption is possible. The effects of EDCs are likely to cascade into a plurality of complex physiological effects, beyond the few variables tested within research studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Cigdem Sevim, Ali Taghizadehghalehjoughi, Mehtap Kara
Summary: This study investigated the cytotoxicity of a mixture of six pesticides, finding that the mixture reduced antioxidant status and increased reactive oxygen production in cells. Oxidative stress played a significant role in the observed cytotoxicity during pesticide mixture exposure.
ISTANBUL JOURNAL OF PHARMACY
(2021)
Review
Food Science & Technology
Summary: On 8 July 2021, EFSA published a Conclusion on the pesticide risk assessment for acibenzolar-S-methyl, stating that the assessment of endocrine-disrupting properties could not be finalized due to insufficient data. Consequently, the European Commission initiated a review of the existing approval. On 14 December 2022, EFSA was requested by the European Commission to consider the proposed studies submitted by the applicant to complete the assessment in line with Commission Regulation (EU) 2018/605. This statement presents EFSA's considerations on the testing strategy and timelines for additional data generation proposed by the applicant.
Article
Fisheries
Helena Robattini Carvalho, Diogenes Henrique De Siqueira-Silva, Romulo Batista Rodrigues, Louise Nex Spica, Daniel Antonio Rotili, Everton Luis Zardo, Andrea Giannotti Galuppo, Renata Villar, Juan Ramon Esquivel-Muelbert, Jayme Aparecido Povh, Leonardo Barcellos, Danilo Pedro Streit Jr
Summary: The effect of temperature on gonadal development and sex ratio in Brycon orbignyanus was assessed in this study. Fish were kept at three different temperatures (20°C, 23°C, and 26°C) from the beginning of exogenous feeding. Results showed that the sexual pattern was temperature-dependent, with undifferentiated individuals at 20°C and a higher proportion of immature males at 23°C and males in maturation process and regression phase at 26°C. Testosterone levels were quantified in all treatments, while detectable estradiol levels were found only at 23°C. Continuous exposure to 23°C and 26°C favored testicular development, with faster gonadal development observed at 26°C.
Article
Pharmacology & Pharmacy
Wagner Antonio Tamagno, Carla Alves, Aline Pompermaier, Hevilin Correa dos Santos, Leonardo Jose Gil Barcellos
Summary: This study investigated the effects of exposure to a commercial transfluthrin-based insecticide on behavior and biochemical biomarkers in a Caenorhabditis elegans model system. The results showed that the exposure to transfluthrin-based insecticide had persistent transgenerational effects on behavior and biochemical patterns, and could be harmful to non-target species, including humans.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tania Maria Lopes dos Santos, Elen Monique de Oliveira Sousa, Monica Yumi Tsuzuki, Alex Pires de Oliveira Nuner, Leonardo Jose Gil Barcellos
Summary: The trade of aquarium organisms is expanding globally, but few initiatives have been taken to ensure sustainability. However, there has been a growing interest in researching captive breeding of these animals to promote a more sustainable aquarium hobby. In this study, we investigated how background color affects the endocrine stress response of tomato clownfish larvae, and found that white tanks should be avoided for larviculture. Using colored tanks can lead to less stress and better welfare conditions for captive-bred clownfish, which has practical applications for the ornamental aquarium trade.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Fabiano V. Costa, Tatiana O. Kolesnikova, David S. Galstyan, Nikita P. Ilyin, Murilo S. de Abreu, Elena V. Petersen, Konstantin A. Demin, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Psychiatric disorders are prevalent brain pathologies. Reliable animal models are needed for effective treatment. Zebrafish show complex behaviors similar to rodents and humans, making them suitable for modeling psychiatric disorders. However, there are challenges and the field needs further discussion and consideration of clinical prevalence and pathological complexity. Recent developments in molecular biology might pave the way for wider use of zebrafish in CNS disease modeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ivana F. Rosa, Ana P. B. Pecanha, Tabata R. B. Carvalho, Leonardo S. Alexandre, Vinicius G. Ferreira, Lucas B. Doretto, Beatriz M. Souza, Rafael T. Nakajima, Patrick da Silva, Ana P. Barbosa, Leticia Gomes-de-Pontes, Camila G. Bomfim, Glaucia M. Machado-Santelli, Antonio Condino-Neto, Cristiane R. Guzzo, Jean P. S. Peron, Magaiver Andrade-Silva, Niels O. S. Camara, Anali M. B. Garnique, Renata J. Medeiros, Fausto K. Ferraris, Leonardo J. G. Barcellos, Jose D. Correia-Junior, Jorge Galindo-Villegas, Monica F. R. Machado, Angela Castoldi, Susana L. Oliveira, Camila C. Costa, Marco A. A. Belo, Giovane Galdino, German G. Sgro, Natalia F. Bueno, Silas F. Eto, Flavio P. Veras, Bianca H. V. Fernandes, Paulo R. S. Sanches, Eduardo M. Cilli, Guilherme Malafaia, Rafael H. Nobrega, Aguinaldo S. Garcez, Emanuel Carrilho, Ives Charlie-Silva
Summary: The study investigates the potential effect of red photobiomodulation (PBM) as a therapy for COVID-19. The findings suggest that inflammation is a significant feature of the disease, and PBM can help regulate the inflammatory response. Metabolomics analysis also reveals shared impacts on metabolic pathways between PBM and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yuriy M. Kositsyn, Murilo S. de Abreu, Tatiana O. Kolesnikova, Alexey A. Lagunin, Vladimir V. Poroikov, Hasmik S. Harutyunyan, Konstantin B. Yenkoyan, Allan V. Kalueff
Summary: Depression and schizophrenia are common and debilitating neuropsychiatric disorders, for which current pharmacotherapies have limited efficacy and significant side effects. This highlights the need for novel drug targets. Recent advancements in translational research, research tools, and approaches have provided potential avenues for innovative drug discovery. This article provides a comprehensive overview of current treatments and outlines potential molecular targets for these disorders, while also addressing translational challenges and unanswered questions to encourage further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anton D. D. Shevlyakov, Tatiana O. O. Kolesnikova, Murilo S. S. de Abreu, Elena V. V. Petersen, Konstantin B. B. Yenkoyan, Konstantin A. A. Demin, Allan V. V. Kalueff
Summary: Epilepsy is a neurological disorder characterized by seizures and neuronal hyperactivity. The exact pathogenesis is not fully understood, but genetic factors are known to play a key role. In this study, a computational approach was used to generate a comprehensive network of molecular pathways associated with epilepsy. The study identified potential key interactors and revealed functional molecular pathways, highlighting the importance of targeting downstream pathways for more effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Amanda Carolina Cole Varela, Suelen Mendonca Soares, Milena Fortuna, Vitoria Cadore Costa, Isis Piasson Barletto, Mateus Timbola Mozatto, Lisiane Siqueira, Heloisa Helena de Alcantara Barcellos, Rodrigo Egydio Barreto, Leonardo Jose Gil Barcellos
Summary: The aim of this study was to examine whether a single acute exposure of a glyphosate-based herbicide (GBH) affected the growth performance of Nile tilapia fingerlings during the first 90 days of culture. The findings suggest that GBH increases serotoninergic activity, which affects fish anorexically. In addition, the fish were also exposed to fluoxetine (FLU), a drug that increases serotoninergic activity. The results showed that fingerlings exposed to GBH or FLU had decreased growth performance compared to unexposed fish.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Neurosciences
Wagner Antonio Tamagno, Carla Alves, Aline Pompermaier, Francieli Ubirajara India Amaral, Natalia Freddo, Suelen Mendonca Soares, Tayllana Schwanke Goncalves, Lisiane Siqueira, Milena Fortuna, Hevilin Correa dos Santos, Amanda Gorrosterrazu, Gustavo Kellermann Reolon, Leonardo Jose Gil Barcellos
Summary: Pyrethroid-based insecticides, such as prallethrin and transfluthrin, are commonly used for mosquito control. These compounds affect the nervous system of insects by keeping the sodium channels open, leading to hyperexcitability and eventually death. This study examined the effects of chronic exposure to these insecticides on zebrafish, focusing on their behavior and the activity of the enzyme acetylcholinesterase (AChE) in different brain regions. The results showed that both compounds caused anxiolytic behavior, reduced shoaling formation, and impaired social interaction in zebrafish. The AChE activity was also found to be modulated by these compounds, suggesting a possible link between pyrethroid insecticides and neurological disorders such as autism spectrum disorder and schizophrenia.
Article
Behavioral Sciences
Amanda C. dos Santos, Murilo S. de Abreu, Gabriel P. de Mello, Vanusa Costella, Nicoli R. do Amaral, Alexander Zanella, Julia Poletto, Elena Petersen, Allan Kalueff, Ana C. V. V. Giacomini
Summary: Music therapy has positive effects on improving cognitive function and mood in humans and animals. This study examines the impact of solfeggio-frequency music exposure on behavior, cognition, and endocrine parameters in adult zebrafish that were subjected to a disturbance in circadian rhythm. It was found that continuous exposure to music for 24 hours or intermittent exposure for 2 or 6 hours twice daily reversed the cognitive deficits and elevated cortisol levels caused by 24-hour light exposure. These findings highlight the positive modulation of cognitive and endocrine responses in adult zebrafish through long-term music exposure.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Endocrinology & Metabolism
Lucas Ferreira Teixeira, Gustavo R. Krupp Prauchner, Darlan Gusso, Angela T. S. Wyse
Summary: Classic galactosemia is a rare inborn error of metabolism caused by gene variants leading to absent or misfolded enzyme, resulting in galactose metabolite accumulation and cell damage. Its symptoms vary and prevalence differs among populations. Dairy restriction is a common treatment, but recent studies suggest its reconsideration in certain cases. Further preclinical trials are needed to understand the disease and propose new treatments.
METABOLIC BRAIN DISEASE
(2023)
Review
Neurosciences
Darlan Gusso, Gustavo Ricardo Krupp Prauchner, Alessandra Schmitt Rieder, Angela T. S. Wyse
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early social communication deficits. This review focuses on the role of folate, vitamin B12, and vitamin D in ASD, as well as the potential impact of nutrient deficiency or hypersupplementation during fetal development. The review also discusses the relationship between stress during pregnancy, cortisol levels, and ASD prevalence.
NEUROTOXICITY RESEARCH
(2023)
Article
Fisheries
Tania Maria Lopes dos Santos, Elen Monique de Oliveira Sousa, Monica Yumi Tsuzuki, Leonardo Jose Gil Barcellos, Alex Pires de Oliveira Nuner
Summary: The color of the environment affects the early development and metamorphosis process of Tomato Clownfish. The metamorphosis of Tomato Clownfish can be accelerated in darker-color conditions, especially black aquaria.
NORTH AMERICAN JOURNAL OF AQUACULTURE
(2023)
Article
Environmental Sciences
Suelen Mendonca-Soares, Milena Fortuna, Natalia Freddo, Amanda Carolina Cole Varela, Aline Pompermaier, Mateus Timbola Mozzato, Vitoria Cadore Costa, Wagner Antonio Tamagno, Luciana Grazziotin Rossato-Grando, Leonardo Jose Gil Barcellos
Summary: The effects of 30-minute exposure to environmentally relevant concentrations of imidacloprid-based insecticides (IBIs) on the behavior, redox status, and cortisol levels of zebrafish were investigated. The results showed that IBI decreased fish locomotion and social and aggressive behaviors and induced an anxiolytic-like behavior. Furthermore, IBI increased cortisol levels and protein carbonylation and decreased nitric oxide levels. These changes were mainly observed at concentrations of 0.013 and 0.0013 μg·L-1 of IBI. In an environmental context, these behavioral and physiological imbalances can impair the ability of fish to evade predators and affect their survival.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Veterinary Sciences
Maria M. Kotova, David S. Galstyan, Tatiana O. Kolesnikova, Murilo S. de Abreu, Tamara G. Amstislavskaya, Tatyana Strekalova, Elena V. Petersen, Konstantin B. Yenkoyan, Konstantin A. Demin, Allan V. Kalueff
Summary: Antimicrobial drugs can influence the central nervous system and gut microbiota, leading to changes in brain and behavior. Zebrafish models are useful for studying the effects of these drugs on the central nervous system. Recent research has revealed the impacts of a wide range of antimicrobial drugs on brain and behavior in zebrafish.
VETERINARY SCIENCES
(2023)
