Journal
CHEMOSPHERE
Volume 112, Issue -, Pages 92-99Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2014.03.071
Keywords
CdSe QDs; Yeast; Biological effect; Toxicity; Microcalorimetry
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Funding
- Chinese 973 Program [2011CB933600]
- National Natural Science Foundation of China [21225313, 21303126]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1030]
- Fundamental Research Funds for Central Universities [2042014kf0287]
- SRF
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The interactions between quantum dots (QDs) and biological systems have attracted increasing attention due to concerns on possible toxicity of the nanoscale materials. The biological effects of CdSe QDs and CdSe/ZnS QDs with nearly identical hydrodynamic size on Saccharomyces cerevisiae were investigated via microcalorimetric, spectroscopic and microscopic methods, demonstrating a toxic order CdSe > CdSe/ZnS QDs. CdSe QDs damaged yeast cell wall and reduced the mitochondrial membrane potential. Noteworthy, adhesion of QDs to the yeast cell surface renders this work a good example of interaction site at cell surface, and the epitaxial coating of ZnS could greatly reduce the toxicity of Cd-containing QDs. These results will contribute to the safety evaluation of quantum dots, and provide valuable information for design of nanomaterials. (C) 2014 Elsevier Ltd. All rights reserved.
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