Article
Chemistry, Physical
Kyung Hee Park, Yeon Woo Choi, Heejoo Ryu, Hyoung Jae Lee, Jae-Hak Moon, Ho-Jun Song, Yeong-Joon Park
Summary: This study developed improved multi-component beads for controlled and sustained delivery of antibiotics. Single and multi-component beads were prepared using chitosan, calcium chloride, alginate, and citric acid, and the release of antibiotics was controlled by crosslinking. The crosslinked beads showed efficient sustained-release of gentamicin.
Article
Nanoscience & Nanotechnology
Ishtpreet Kaur, Shekhar Agnihotri, Dinesh Goyal
Summary: In this study, insecticide cartap hydrochloride was fabricated as nanospheres using a two-step method. The nanospheres showed good stability and encapsulation efficiency. The release experiments indicated that the nanospheres had controlled release properties.
Article
Materials Science, Multidisciplinary
W. Ramos-Torres, Rocio Borges-Argaez, P. Gonzalez-Chi
Summary: Hybrid microspheres composed of PAL nanoclay and crosslinked QS were prepared to trap and control the release of TIM. The hybrid microspheres showed higher encapsulation efficiency and more uniform size distribution compared to pristine chitosan microspheres, and the thymol release kinetics was modified by the palygorskite content.
MATERIALS RESEARCH EXPRESS
(2021)
Article
Biochemistry & Molecular Biology
Hao Zhuang, Jinyu Shao, Peixuan Wu, Gaobo Yu, Kun Fu, Zhicheng Sun, Meijuan Cao, Yuanyuan Liu, Yang Zhou
Summary: In this study, the controlled release of nitric oxide (NO) from alginate microspheres was achieved through the direct impregnation of S-nitroso-N-acetyl-penicillamine (SNAP) in the gelation of sodium alginate with calcium ions. The loading rate of SNAP in alginate microspheres ranged from 0.69% to 27.5%, and the longest NO release time reached up to 93 hours. The NO-releasing spheres demonstrated excellent antibacterial properties against Escherichia coli and Staphylococcus aureus, and showed great potential for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jinglei Li, Haishan Wu, Kexin Jiang, Yuting Liu, Liu Yang, Hyun Jin Park
Summary: An effective delivery system for oral insulin administration was developed using alginate microbeads containing chitosan nanoparticles (CNP) for controlled release of insulin. The optimized CNP with a size around 150 nm and encapsulation efficiency of 23.70% showed promising potential for oral insulin delivery. The insulin-loaded alginate microbeads significantly lowered blood glucose level in hyperglycemia model mice in a controlled manner for up to 96 hours, demonstrating the potential for extended release of insulin.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dong Yang, Keyi Gao, Yang Bai, Lei Lei, Tongtong Jia, Kaidi Yang, Chaohua Xue
Summary: This study utilized a microfluidic approach to synthesize magnetic alginate microparticles and chitosan-coated magnetic alginate microparticles, achieving controlled drug release. By investigating the model drug amoxicillin, it was found that particle size affects drug release rate, while chitosan coating extended drug release time by two times.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Zeou Dou, Maria Vitoria Bini Farias, Wensi Chen, Dongjing He, Yuhang Hu, Xing Xie
Summary: This study presents a controlled-release fertilizer excipient based on chitosan and montmorillonite, which can reduce fertilizer loss, improve soil water retention, and has high degradability with minimal impact on long-term soil fertility.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
M. Cirri, F. Maestrelli, S. Scuota, V Bazzucchi, P. Mura
Summary: Metronidazole-loaded vaginal multiparticulate systems were developed to improve drug release, with the best formulation demonstrating efficacy in treating local diseases based on various performance tests conducted.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zhaoxia Tang, Jiali Luo, Yahya Faqir, Yu Zhang, Wenqian Xue, Hongmei Zhao, Ali Murad Jakhar, Chengjia Tan, Jiahua Ma
Summary: This study aimed to treat mice with colitis using dung beetle chitosan (DCS)-transported berberine hydrochloride (BH). BH-loaded DCS/sodium alginate microspheres (SA-DCS-BH) were successfully prepared and characterized. The results showed that SA-DCS-BH had slow-release ability, reduced inflammation, modulated gut microbiota, and DCS was a more suitable carrier compared to commercial chitosan for intestinal drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Polymer Science
Olimpia Daniela Frent, Narcis Duteanu, Alin Cristian Teusdea, Stefania Ciocan, Laura Vicas, Tunde Jurca, Mariana Muresan, Annamaria Pallag, Paula Ianasi, Eleonora Marian
Summary: The aim of this study was to prepare microspheres based on biodegradable polymers and load them with a water-insoluble and environmentally sensitive active drug. The experimental results showed that the prepared microspheres had a high drug entrapment rate and could achieve controlled release of the active drug at the intestinal level. Furthermore, the microspheres exhibited good thermal stability, making them suitable for drug delivery systems.
Article
Biochemistry & Molecular Biology
Wenqing Li, Wei Li, Yulian Wan, Longfeng Wang, Tao Zhou
Summary: In this study, e-poly-lysine-epigallocatechin gallate/sodium alginate-chitosan nanoparticles (e-PL-EGCG/ SA-CS NPs) with good size, encapsulation efficiency, thermal stability and sustained release capability were successfully prepared. The NPs showed significant antibacterial activity against specific spoilage bacteria and therefore, have great potential in aquatic products preservation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Esraa G. Arafa, Magdy W. Sabaa, Riham R. Mohamed, Emadeldin M. Kamel, Ali M. Elzanaty, Ayman M. Mahmoud, Omayma F. Abdel-Gawad
Summary: This study synthesized a superabsorbent hydrogel for controlled-release urea, which showed swelling, urea release, and antimicrobial properties suitable for efficient water management and economic and environmental benefits in agriculture.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Nechikkottil Sivadasan Sumitha, Prabha Prakash, Balagopal N. Nair, Gopalakrishnanchettiar Sivakamiammal Sailaja
Summary: Glyoxal cross-linked porous magnetic chitosan microspheres (GMS) were synthesized using a water-in-oil emulsion technique for controlled delivery of doxorubicin (DOX) with prolonged chemotherapeutic effects. GMS exhibited superparamagnetism and excellent cytocompatibility, with a release mechanism involving diffusion-inspired release through the swollen polymer network and regulated degradation release.
Article
Chemistry, Multidisciplinary
Tiantian Yang, Nannan Suo, Wenjie Tang, Haiyang Ma, Yang Liu, Meiling Wen
Summary: Microspheres with a small specific surface area can improve drug encapsulation rate, achieve sustained release of drugs, and provide a reference for long-term wound healing treatment. Core spheres with sodium alginate (SA) were prepared using ion cross-linking and curing method, with chitosan shell coating the outer layer, and the inner and outer layers modified by different concentrations of polyethylene glycol (PEG) and sodium polyphosphate (TPP). Characterization of the core spheres and bilayer microspheres was performed through scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), swelling experiments, drug sustained release, and pH sensitivity. The results showed that both the core spheres and bilayer microspheres exhibited dispersed spheres with a more uniform particle size distribution. Furthermore, drug sustained-release experiments indicated that the addition of PEG improved the drug sustained-release performance of core spheres, while the addition of TPP improved the drug sustained-release performance of bilayer microspheres.
Article
Chemistry, Multidisciplinary
Islam Gomaa, Merna H. H. Emam, Ahmed R. R. Wassel, Kholoud Ashraf, Sara Hussan, Haitham Kalil, Mekki Bayachou, Medhat A. A. Ibrahim
Summary: A synergistic interaction between reduced graphene oxide (rGO) and sodium alginate was used to create spiky microspheres for sustained release of cefotaxime. The microspheres were characterized and their release profiles were determined. The antibacterial activity of the microspheres was also tested against E. coli. The results demonstrated the potential of the rGO/alginate matrix for enhanced cefotaxime delivery with prolonged release.
