Journal
CHEMOSPHERE
Volume 73, Issue 3, Pages 337-343Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2008.05.072
Keywords
Apoptosis; ROS; NO; Na+/K+-ATPase
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Funding
- National Natural Science Foundation [40606027, 20777061]
- State Key Laboratory of Marine Environmental Science, Xiamen University, China [MEL0606]
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Tributyltin (TBT) is a ubiquitous marine environmental contaminant characterized primarily by its reproductive toxicity. However, the neurotoxic effect of TBT has not been extensively described, especially in fishes which have a high number of species in the marine environment. This study was conducted to investigate the neurotoxic effects of TBT at environmental levels (1, 10, and 100 ng l(-1)) on female Sebastiscus marmoratus. The results showed that TBT exposure induced apoptosis in brain cells of three regions including the pallial areas of the telencephalon, the granular layer of the optic tectum, and the cerebellum. In addition, the increase of reactive oxygen species and nitric oxide levels, and the decrease of Na+/K+-ATPase activity were found in the brain. The results strongly indicated neurotoxicity of TBT to fishes. According to the regions in which apoptosis was found in the brain, TBT exposure might influence the schooling, sensory and motorial functions of fishes. (C) 2008 Elsevier Ltd. All rights reserved.
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