Article
Environmental Sciences
Shaojing Sun, Fan Meng, Hong Qi
Summary: An online solid-phase extraction (SPE) liquid chromatography tandem mass spectrometry method (HPLC-MS/MS) combined with accelerated solvent extraction (ASE) was developed for simultaneous determination of 14 pharmaceuticals in sludge. Ultrapure water with no additives was used as the loading solvent in the online SPE procedures. Low molecular weight targets such as atenolol were difficult to retain on SPE column after acetone was added to the washing solvent. By adding 0.2% formic acid to the mobile phase, the response signal of analytes can be greatly improved. Under the optimized conditions, the recoveries of all the analytes ranged between 75.1 and 112%. The limit of detections ranged from 1.8 to 7.9 ug/kg. The precision of analytical data was determined with relative standard deviation (RSD)<= 4.87%. This method was successfully applied to determine the concentration of pharmaceuticals in sludge.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Analytical
Yihuan Song, Feng Guo, Pingxiu Zeng, Jinhua Liu, Yuanchao Wang, Heyong Cheng
Summary: In this study, an analytical method integrating online solid phase extraction with high-performance liquid chromatography and inductively coupled plasma mass spectrometry (ICP-MS) was developed to simultaneously preconcentrate and quantify forms of Cr, Cd, Hg, and Pb in water. The method showed low limits of detection, good linearities, and low variability, and was validated by analyzing reference materials and real water samples.
ANALYTICA CHIMICA ACTA
(2022)
Review
Thermodynamics
Sisi Xu, Yan Zheng, Cunliang Zhang, Feiyong Chen, Yang Song, Fengxia Zhang, Shuxia Zhang, Peng Liu, Lun Meng, Linxu Xu, Jin Wang, Yubo Zhao, Zhigang Yang, Xue Shen
Summary: Controlling pollution, improving sensitivity, and using high resolution mass spectrometry can determine volatile, semi-volatile, and nonvolatile PFASs.
THERMAL SCIENCE AND ENGINEERING PROGRESS
(2023)
Article
Environmental Sciences
Alexandra Jaus, Peter Rhyn, Judit Valentini
Summary: A study in Switzerland found that wild fish may be a source of per- and polyfluorinated substances (PFASs) in the human diet. PFOS was the most abundant compound in subalpine lakes, while PFNA, PFDA, and PFUnDA dominated in high alpine fish.
Article
Biochemistry & Molecular Biology
Yage Guo, Jun Xie, Fengshou Dong, Xiaohu Wu, Xinglu Pan, Xingang Liu, Yongquan Zheng, Jie Zhang, Jun Xu
Summary: In this study, a simple and fast method was developed for the trace analysis of 90 pesticides and metabolites in aquatic products. The method showed good linearities and was able to detect three herbicide residues in prawn samples.
Article
Chemistry, Applied
Jing-Wen Hao, Xiao-Quan Liu, Nai-Dong Chen, An-ling Zhu
Summary: The study established a method for the qualitative and quantitative analysis of Ptaquiloside in Pteridium aquilinum using solid-phase extraction (SPE) preconcentration technique combined with TOF-MS/MS and HPLC-DAD analysis. The method showed good repeatability and accuracy for the detection of PTA in P. aquilinum, which can be used for food safety evaluation.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Environmental Sciences
Xuerong Li, Morgan Fatowe, Leila Lemos, Natalia Quinete
Summary: PFAS were detected in tap water and surface water samples from various locations in South and Central Florida, with higher concentrations observed in polluted river and coastal estuary areas. These findings provide important information for the development of more stringent screening levels to protect human health and the environment in Florida.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemical Research Methods
M. Abdul Mottaleb, Qunxing X. Ding, Kelly G. Pennell, Erin N. Haynes, Andrew J. Morris
Summary: A method for direct determination of PFASs in environmental water samples without prior sample concentration was developed and validated. The method involves UPLC-MS/MS analysis with isotope mass-labeled internal standard-based calibration plots, achieving good recoveries.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Pharmacology & Pharmacy
Lu Wang, Sen Li, Jiaxin Li, Zhongzhe Cheng, Yulin Feng, Hui Ouyang, Zhifeng Du, Hongliang Jiang
Summary: In this study, a new method was used to investigate the metabolism of Alismatis Rhizoma triterpene extract, identifying a total of 233 constituents and revealing the major metabolic pathways of triterpenes in vivo. Additionally, the mutual transformation of known triterpenes in Alismatis Rhizoma extract was discovered for the first time.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Agronomy
Tea Ivancic, Jerneja Jakopic, Robert Veberic, Viljanka Vesel, Metka Hudina
Summary: This study was conducted in the harvest season of 2020 to measure and quantify primary and secondary metabolites in the 'Leccino' olive fruit during ripening. Sugars, phenolic compounds, total phenolic content, and tannin content were measured separately in the skin and pulp. The majority of metabolites were found to be higher in the skin, with glucose being the most important sugar. High levels of total phenolic content were observed in the skin at the last stage of ripening, due to the accumulation of anthocyanins. Oleuropein was identified as the main phenolic compound in both the skin and pulp, decreasing during ripening. Two previously unidentified anthocyanins were also discovered in the olive skin. These findings contribute to a better understanding of the synthesis, distribution, and storage of primary and secondary metabolites in different tissues of ripening olive fruits.
Article
Chemistry, Analytical
Laure Wiest, Barbara Giroud, Azziz Assoumani, Francois Lestremau, Emmanuelle Vulliet
Summary: A multi-family analytical strategy for quantifying surfactants in surface waters was developed, optimized, and validated, with the method suitable for monitoring low concentrations of surfactants. Anionic, cationic, and non-ionic surfactants were detected in French river water samples, with median concentrations ranging from 24 ng/L to 4.6 μg/L.
Article
Chemistry, Medicinal
Wei Wu, Ze-neng Cheng
Summary: The study investigated the metabolic and excretory pathways of AKF-PD in rats. The results showed that AKF-PD is mainly metabolized into carboxylated metabolites and excreted from urine.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Chemistry, Analytical
Xinrui Zhang, Shunbo Zhao, Tao Wang, Chang Shu, Li Ding
Summary: This study developed a simple method to simultaneously determine EVT201 and its five metabolites using HPLC-MS/MS with an electrospray ion source. This method was successfully applied to a clinical pharmacokinetic study of EVT201 capsules in humans.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemical Research Methods
Simone Hintze, Youssef Sameh Bahgat Hannalla, Sylvie Guinchard, Daniel Hunkeler, Gaetan Glauser
Summary: Pesticide metabolites are often detected in groundwater at concentrations higher than their parent pesticides, with some metabolites frequently appearing at elevated levels. Developing methods to measure these metabolites in soil and the unsaturated zone is crucial for estimating their impact on groundwater concentrations post-ban.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Applied
Xiangyu Fang, Ji Tang, Sylwia Bajkacz, Rafal Szoltysik
Summary: Ecdysones, analogs of the insect molting hormone ecdysone, have been found in many plant species. This study developed a new analytical method for the simultaneous determination of four ecdysones in plants and found that spinach samples contained the highest levels of these compounds. Culinary practices had some impact on ecdysone stability, with freezing affecting the content of ecdysteroids in plants more negatively.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)