Design and Synthesis of Tricyclic JAK3 Inhibitors with Picomolar Affinities as Novel Molecular Probes

Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 – 2012

(2013) Brian W Dymock et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Identification of C-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2

(2013) Mark Zak et al.   JOURNAL OF MEDICINAL CHEMISTRY

1-[(3RS,4RS)-1-Benzyl-4-methylpiperidin-3-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine hemihydrate

(2012) Ellen Pfaffenrot et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

Tofacitinib for the treatment of rheumatoid arthritis

(2012) Cristiano AF Zerbini et al.   Expert Review of Clinical Immunology

Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

(2012) Mark Zak et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Frozen Analogue Approach to Aminopyridinylimidazoles Leading to Novel and Promising p38 MAP Kinase Inhibitors

(2012) Roland Selig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

(2012) Janusz J. Kulagowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

A public-private partnership to unlock the untargeted kinome

(2012) Stefan Knapp et al.   Nature Chemical Biology

Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

(2011) Keith W. Rickert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxetanes in Drug Discovery: Structural and Synthetic Insights

(2010) Georg Wuitschik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

(2010) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

(2010) Jill E. Chrencik et al.   JOURNAL OF MOLECULAR BIOLOGY

JAK3: A two-faced player in hematological disorders

(2009) Melanie G. Cornejo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains

(2009) Neal K. Williams et al.   JOURNAL OF MOLECULAR BIOLOGY

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

(2008) Jian-kang Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY