Simplified Silvestrol Analogues with Potent Cytotoxic Activity

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II

(2013) Jennifer M. Chambers et al.   ORGANIC LETTERS

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Synthetic Silvestrol Analogues as Potent and Selective Protein Synthesis Inhibitors

(2012) Tao Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of 2‴,5‴-Diepisilvestrol and Its C1‴ Epimer: Key Structure Activity Relationships at C1‴ and C2‴

(2012) Jennifer M. Chambers et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of (±)-Rocaglamide via Oxidation-Initiated Nazarov Cyclization

(2012) John A. Malona et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue

(2012) Dan Balan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

(2012) L M Lindqvist et al.   Cell Death & Disease

Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

(2011) U. V. R. Vijaya Saradhi et al.   AAPS Journal

Recent advances in the biology and chemistry of the flavaglines

(2011) Nigel Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies

(2011) Christina M. Rodrigo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

(2010) Stéphane P. Roche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Flavaglines Displaying Improved Cytotoxicity

(2010) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation and Characterization of Minor Analogues of Silvestrol and Other Constituents from a Large-Scale Re-collection ofAglaia foveolata

(2010) Li Pan et al.   JOURNAL OF NATURAL PRODUCTS

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

(2009) David M. Lucas et al.   BLOOD

Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

(2009) Frédéric Thuaud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of the Potent Anticancer Aglaia Metabolites (−)-Silvestrol and (−)-Episilvestrol and the Active Analogue (−)-4′-Desmethoxyepisilvestrol

(2009) Tim E. Adams et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Total Synthesis and Biological Activity of (±)-Rocaglamide and Its 2,3-Di-epi Analogue

(2008) Hongsen Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective Pharmacological Targeting of a DEAD Box RNA Helicase

(2008) Lisa Lindqvist et al.   PLoS One