Kinetic Properties of Carbohydrate-Lectin Interactions: FimH Antagonists

FimH Antagonists: Structure-Activity and Structure-Property Relationships for Biphenyl α-D-Mannopyranosides

(2012) Lijuan Pang et al.   ChemMedChem

Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success

(2012) Xiaohua Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Flow Cytometry-Based Assay for Screening FimH Antagonists

(2011) Meike Scharenberg et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Taloside Inhibitors of Galectin-1 and Galectin-3

(2011) Patrick M. Collins et al.   Chemical Biology & Drug Design

The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion

(2011) Mirja Hartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Expression of the carbohydrate recognition domain of FimH and development of a competitive binding assay

(2010) Said Rabbani et al.   ANALYTICAL BIOCHEMISTRY

Kinetic and thermodynamic properties of MAG antagonists

(2010) Stefanie Mesch et al.   CARBOHYDRATE RESEARCH

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

(2010) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

FimH Antagonists for the Oral Treatment of Urinary Tract Infections: From Design and Synthesis to in Vitro and in Vivo Evaluation

(2010) Tobias Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of an aggregation assay to screen FimH antagonists

(2010) Daniela Abgottspon et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Binding studies of adhesion/growth-regulatory galectins with glycoconjugates monitored by surface plasmon resonance and NMR spectroscopy

(2010) F. Javier Muñoz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Examination of the Biological Role of the α(2→6)-Linked Sialic Acid in Gangliosides Binding to the Myelin-Associated Glycoprotein (MAG)

(2009) Oliver Schwardt et al.   JOURNAL OF MEDICINAL CHEMISTRY

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Origins and virulence mechanisms of uropathogenic Escherichia coli

(2008) Travis J. Wiles et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex

(2008) Adinda Wellens et al.   PLoS One