Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using19F Ligand-and15N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold

(2012) Martin Tremblay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HIV-1 Antiretroviral Resistance

(2012) Michele W. Tang et al.   DRUGS

Treatment of HIV infection with once-daily regimens

(2012) Nitipong Permpalung et al.   EXPERT OPINION ON PHARMACOTHERAPY

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

(2012) C. T. Lemke et al.   JOURNAL OF VIROLOGY

Generic HIV drugs will widen US treatment net

(2012) Amy Maxmen   NATURE

Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein

(2012) Sawitree Nangola et al.   Retrovirology

New Approaches for Antiviral Targeting of HIV Assembly

(2011) Peter E. Prevelige   JOURNAL OF MOLECULAR BIOLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Rationally Designed Interfacial Peptides Are Efficient In Vitro Inhibitors of HIV-1 Capsid Assembly with Antiviral Activity

(2011) Rebeca Bocanegra et al.   PLoS One

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

(2010) Lee D. Fader et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorine-Protein Interactions and 19F NMR Isotropic Chemical Shifts: An Empirical Correlation with Implications for Drug Design

(2010) Claudio Dalvit et al.   ChemMedChem

Antiretroviral drugs

(2010) Erik De Clercq   CURRENT OPINION IN PHARMACOLOGY

Unmet therapeutic needs in the new era of combination antiretroviral therapy for HIV-1

(2010) B. Taiwo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The future of antiretroviral therapy: challenges and needs

(2010) S. Moreno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

(2010) J. Shi et al.   JOURNAL OF VIROLOGY

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

Novel approaches to inhibiting HIV-1 replication

(2009) Catherine S. Adamson et al.   ANTIVIRAL RESEARCH

Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein

(2009) Baohe Tian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

The structural biology of HIV assembly

(2008) Barbie K Ganser-Pornillos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY